Enacting the molecular imperative: How gene-environment interaction research links bodies and environments in the post-genomic age

Social Science and Medicine

Volumn 155, Issue , 2016, Pages 51-60

  Darling, Katherine Weatherford ^a   Ackerman, Sara L ^a   Hiatt, Robert H ^b   Lee, Sandra Soo Jin ^c   Shim, Janet K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Complex disease; Environment; Gene environment interactions; Genomics; Health inequalities; Molecularization; USA

Indexed keywords

ETIOLOGY; GENOMICS; GENOTYPE-ENVIRONMENT INTERACTION; PUBLIC HEALTH;

AIR POLLUTION; ARTICLE; BODY MASS; BREAST CANCER; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL IMPACT ASSESSMENT; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HEALTH BEHAVIOR; HUMAN; HYPERTENSION; MEDICAL RESEARCH; NEOPLASM; OBESITY; RISK FACTOR; SOCIAL ENVIRONMENT; WAIST HIP RATIO; CARDIOVASCULAR DISEASES; GENETICS; GENOMICS; NEOPLASMS; UNITED STATES;

UNITED STATES;

CARDIOVASCULAR DISEASES; DIABETES MELLITUS; GENE-ENVIRONMENT INTERACTION; GENETIC RESEARCH; GENOMICS; HUMANS; NEOPLASMS; UNITED STATES;

EID: 84960906058     PISSN: 02779536     EISSN: 18735347     Source Type: Journal    
DOI: 10.1016/j.socscimed.2016.03.007     Document Type: Article

References (37)

1. Ackerman S.L., Darling K.W., Lee S.S.-J., Hiatt R.A., Shim J.K. Accounting for complexity: gene-environment interaction research and the moral economy of quantification. Sci. Technol. Hum. Values 2016, 41(2):194-218. 10.1177/0162243915595462.
2. Charmaz K. Constructing Grounded Theory: a Practical Guide through Qualitative Analysis 2006, Sage Publications, London; Thousand Oaks, California.
3. Duster T. Comparative perspectives and competing explanations: taking on the newly configured reductionist challenge to sociology. Am. Sociol. Rev. 2006, 71(1):1-15.
4. Frickel S. Chemical Consequences: Environmental Mutagens, Scientist Activism, and the Rise of Genetic Toxicology 2004, Rutgers University Press, New Brunswick, N.J.
5. Kenney M., Muller R. Of Rats and Women: Narratives of Motherhood in Environmental Epigenetics 2016, (forthcoming).
6. Khoury M.J., Bowen M.S., Burke W., Coates R.J., Dowling N.F., Evans J.P., St.Pierre J. Current priorities for public health practice in addressing the role of human genomics in improving population health. Am. J. Prev. Med. 2011, 40(4):486-493. 10.1016/j.amepre.2010.12.009.
7. Krieger N. Proximal, distal, and the politics of causation: what's level got to do with it?. Am. J. Public Health 2008, 98(2):221-230.
8. Krieger N. Epidemiology and the People's Health: Theory and Context 2011, Oxford University Press, New York, N.Y.
9. Landecker H. Food as exposure: nutritional epigenetics and the new metabolism. BioSocieties 2011, 6(2):167-194.
10. Landecker H., Panofsky A. From social structure to gene regulation, and back: a critical introduction to environmental epigenetics for sociology. Annual Review of Sociology 2013, vol. 39. Palo Alto, California: Annual Reviews.
11. Lappé M., Landecker H. How the genome got a life span. New Genet. Soc. 2015, 34(2):152-176. 10.1080/14636778.2015.1034851.
12. Link B.G., Phelan J.C. Social conditions as fundamental causes of disease. J. Health Soc. Behav. 1995, 80-94. Extra Issue.
13. Lock M. Encounters with Aging: Mythologies of Menopause in Japan and North America 1993, University of California Press, Berkeley.
14. Lock M. The epigenome and nature/nurture reunification: a challenge for anthropology. Med. Anthropol. 2013, 32(4):291-308.
15. Manolio T.A., Bailey-Wilson J.E., Collins F.S. Genes, environment and the value of prospective cohort studies. Nat. Rev. Genet. 2006, 7(10):812-820. 10.1038/nrg1919.
16. Marmot M. Understanding social inequalities in health. Perspect. Biol. Med. 2003, 46(Suppl. 3):S9-S23.
17. Murphy M. Sick Building Syndrome and the Problem of Uncertainty: Environmental Politics, Technoscience, and Women Workers 2006, Duke University Press, Durham, North Carolina.
18. National Human Genome Research Institute The Genes, Environment and Health Initiative (GEI) 2014, Retrieved January 12, 2014, from. http://www.genome.gov/19518663.
19. National Research Council of the National Academies Toward Precision Medicine Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 2011, The National Academies Press, Washington D.C., Retrieved from. http://site.ebrary.com/id/10531105.
20. Nelson N.C. Modeling mouse, human, and discipline: epistemic scaffolds in animal behavior genetics. Soc. Stud. Sci. 2013, 43(1):3-29. 10.1177/0306312712463815.
21. Niewohner J. Epigenetics: embedded bodies and the molecularisation of biography and milieu. BioSocieties 2011, 6(3):279-298.
22. Olden K., Freudenberg, Dowd, Shields Discovering how environmental exposures alter genes could lead to new treatments for chronic illnesses. J. Epidemiol. Community Health 2011, 65(6):833-841.
23. Phelan J., Link B., Tehranifar P. Social conditions as fundamental causes of health inequalities: theory, evidence, and policy implications. J. Health Soc. Behav. 2010, 51:28-40. 10.1177/00221 46510383498.
24. Reed K. It's them faulty genes again: women, men and the gendered nature of genetic responsibility in prenatal blood screening. SHIL Sociol. Health Illn. 2009, 31(3):343-359.
25. Rose N. The Politics of Life Itself Biomedicine, Power, and Subjectivity in the Twenty-first Century 2006, Princeton University Press, Princeton, N.J.
26. Rose N. Molecular biopolitics, somatic ethics and the spirit of biocapital. Soc. Theory Health 2007, 5(1):3-29.
27. Shim J.K., Ackerman S.L., Darling K., Hiatt R.A., Lee S.S.-J. Race and ancestry in the age of inclusion: technique and meaning in post-genomic science. J. Health Soc. Behav. 2014, 55(4):504-518.
28. Shim J.K., Darling K.W., Lappe M.D., Thomson L.K., Lee S.S.-J., Hiatt R.A., Ackerman S.L. Homogeneity and heterogeneity as situational properties: producing - and moving beyond? - race in post-genomic science. Soc. Stud. Sci. 2014, 44(4). (Sage Publications, Ltd.).
29. Shostak S. Locating gene-environment interaction: at the intersections of genetics and public health. Soc. Sci. Med. 2003, 56(11).
30. Shostak S. The emergence of toxicogenomics: a case study of molecularization. Soc. Stud. Sci. 2005, 35(3):367-403. 10.2307/25046649.
31. Shostak S. Translating at work: genetically modified mouse models and molecularization in the environmental health sciences. Sci. Technol. Hum. Values 2007, 32(3):315-338. http://doi.org/10.2307/29733988.
32. Shostak S. Exposed Science: Genes, the Environment, and the Politics of Population Health 2013, Duke University Press, Durham, North Carolina.
33. Shostak S., Moinester M. Beyond geneticization: regimes of perceptibility and social determinants of health. Reimagining Biomedicalization, Pharmaceuticals, and Genetics 2015, Routledge, New York, NY.
34. Tabery J. Beyond versus: the Struggle to Understand the Interaction of Nature and Nurture 2014, MIT Press, Cambridge, Mass.
35. Timmermans S., Buchbinder M. Patients-in-waiting: living between sickness and health in the genomics era. J. Health Soc. Behav. 2010, 51(4):408-423.
36. Tutton R., Jamie K. Personalized medicine in context: social science perspectives. Drug Discov. Today Ther. Strateg. 2013, 10(4):e183-e187.
37. Weis B.K., Balshaw D., Barr J.R., Brown D., Ellisman M., Lioy P., Wilson S.H. Personalized exposure assessment: promising approaches for human environmental health research. Environ. Health Perspect. 2005, 113(7):840-848. 10.1289/ehp.7651.