A meta-analysis on the effect of ulinastatin on serum levels of C-reactive protein, interleukin 6, and tumor necrosis factor alpha in asian patients with acute pancreatitis

Genetic Testing and Molecular Biomarkers

Volumn 20, Issue 3, 2016, Pages 118-124

  Zhang, Chunze ^a   Wang, Yijia ^a   Fu, Wenzheng ^a   Zhang, Weihua ^a   Wang, Tao ^a   Qin, Hai ^a  

^a Tianjin Union Medicine Centre   (China)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN; GLYCOPROTEIN; TRYPSIN INHIBITOR; TUMOR NECROSIS FACTOR;

ACUTE PANCREATITIS; ARTICLE; ASIAN; DRUG EFFECT; HUMAN; META ANALYSIS; MONTE CARLO METHOD; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS; ACUTE DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; CHINA; METABOLISM; PANCREATITIS;

ACUTE DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; C-REACTIVE PROTEIN; CHINA; GLYCOPROTEINS; HUMANS; INTERLEUKIN-6; PANCREATITIS; TRYPSIN INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960891736     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2015.0192     Document Type: Article

References (46)

1. Abraham P, Rodriques J, Moulick N, et al. (2013) Efficacy and safety of intravenous ulinastatin versus placebo along with standard supportive care in subjects with mild or severe acute pancreatitis. J Assoc Physicians India 61:535-538.
2. Avsar AF, Yildirim M, Cinkaya A (2014) Unexpected fetal demise despite the reactive nonstress test during the conservative management of acute pancreatitis in pregnancy. Int J Surg Case Rep 5:1047-1049.
3. BAO RW (2013) Effects of ulinastatin on serum hs-CRP, IL-8 and IL-10 in patients with severe acute pancreatitis. J Radioimmunol 26:683-684.
4. Cao YZ, Tu YY, Chen X, et al. (2012) Protective effect of Ulinastatin against murine models of sepsis: inhibition of TNF-alpha and IL-6 and augmentation of IL-10 and IL-13. Exp Toxicol Pathol 64:543-547.
5. Chen H, Manning AK, Dupuis J (2012) A method of moments estimator for random effect multivariate meta-analysis. Biometrics 68:1278-1284.
6. Chen P, Huang L, Sun Y, et al. (2011) Upregulation of PIAS1 protects against sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury. Cytokine 54: 305-314.
7. Chen S, Shi H, Zou X, et al. (2010) Role of ulinastatin in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: the Emperors New Clothes or Aladdins Magic Lamp? Pancreas 39:1231-1237.
8. Digalakis MK, Katsoulis IE, Biliri K, et al. (2009) Serum profiles of C-reactive protein, interleukin-8, and tumor necrosis factor-alpha in patients with acute pancreatitis. HPB Surg 2009:878490.
9. Egger M, Davey Smith G, Schneider M, et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
10. Ferrenberg AM, Swendsen RH (1988) New Monte Carlo technique for studying phase transitions. Phys Rev Lett 61: 2635-2638.
11. Fisic E, Poropat G, Bilic-Zulle L, et al. (2013) The role of IL-6, 8, and 10, sTNFr, CRP, and pancreatic elastase in the prediction of systemic complications in patients with acute pancreatitis. Gastroenterol Res Pract 2013:282645.
12. Gao C, Huan J, Li W, et al. (2009) Protective effects of ulinastatin on pancreatic and renal damage in rats following early scald injury. Burns 35:547-552.
13. Guan W (2011) Influence of ulinastatin on serum TNF-a, IL-6 and hs-CRP in patients with severe acute pancreatitis. Jilin medical 32:6604-6605.
14. Ho YP, Chiu CT, Sheen IS, et al. (2011) Tumor necrosis factoralpha and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis. Hum Immunol 72:18-23.
15. Hou J, Zhu MW, He XW, et al. (2010) Effect of hyperbaric oxygen and ulinastatin on plasma endotoxin, soluble CD14, endotoxin-neutralizing capacity and cytokines in acute necrotizing pancreatitis. Can J Surg 53:241-245.
16. Huang FL (2009) The effect of ulinastatin and on serum IL-6, TNF-a, liver and kidney function of patients with severe acute pancreatitis. Shandong medicine 49:84-85.
17. Huizenga HM, Visser I, Dolan CV (2011) Testing overall and moderator effects in random effects meta-regression. Br J Math Stat Psychol 64:1-19.
18. Jackson D, White IR, Riley RD (2012) Quantifying the impact of between-study heterogeneity in multivariate metaanalyses. Stat Med 31:3805-3820.
19. Khanna AK, Meher S, Prakash S, et al. (2013) Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI scores, IL-6, CRP, and procalcitonin in predicting severity, organ failure, pancreatic necrosis, and mortality in acute pancreatitis. HPB Surg 2013:367581.
20. Lai SW, Lin CL, Liao KF, et al. (2015) Amiodarone use and risk of acute pancreatitis: a population-based case-control study. Heart Rhythm 12:163-166.
21. Lili X, Zhiyong H, Jianjun S (2013) A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery. Neurosci Lett 541:15-19.
22. Liu R, Qi H,Wang J, et al. (2014) Ulinastatin activates the reninangiotensin system to ameliorate the pathophysiology of severe acute pancreatitis. J Gastroenterol Hepatol 29:1328-1337.
23. Ma T, Kang C, Shao H, et al. (2006) Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis. Eur Surg Res 38:445-450.
24. Maciejewski R, Burdan F, Burski K, et al. (2005) Selected biochemical parameters and ultrastructural picture of pancreas due to Ulinastatin treatment of experimental acute pancreatitis. Exp Toxicol Pathol 56:305-311.
25. Maleth J, Balazs A, Pallagi P, et al. (2015) Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis. Gastroenterology 148:427-439 e416.
26. Ozhan G, Yanar HT, Ertekin C, et al. (2010) Polymorphisms in tumour necrosis factor alpha (TNFalpha) gene in patients with acute pancreatitis. Mediators Inflamm 2010:482950.
27. Park KH, Lee KH, Kim H, et al. (2010) The anti-inflammatory effects of ulinastatin in trauma patients with hemorrhagic shock. J Korean Med Sci 25:128-134.
28. Peters JL, Sutton AJ, Jones DR, et al. (2006) Comparison of two methods to detect publication bias in meta-analysis. JAMA 295:676-680.
29. Pini M, Rhodes DH, Castellanos KJ, et al. (2012) Role of IL-6 in the resolution of pancreatitis in obese mice. J Leukoc Biol 91:957-966.
30. Shen QW (2012) Serum hs-CRP and prognosis of Ulinastatin on patients with severe pancreatitis. Journal of medicine and clinical medicine 50:70-71.
31. Shen Y, Cui N, Miao B, et al. (2011) Immune dysregulation in patients with severe acute pancreatitis. Inflammation 34:36-42.
32. Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54:1046-1055.
33. Stevens T, Parsi MA, Walsh RM (2009) Acute pancreatitis: problems in adherence to guidelines. Cleve Clin J Med 76:697-704.
34. Tsujino T, Komatsu Y, Isayama H, et al. (2005) Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial. Clin Gastroenterol Hepatol 3:376-383.
35. Turkoglu A, Boyuk A, Tanriverdi MH, et al. (2014) The potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: a prospective cohort study. Int J Surg 12:1310-1313.
36. Wang G, Wen J, Wilbur RR, et al. (2013) The effect of somatostatin, ulinastatin and Salvia miltiorrhiza on severe acute pancreatitis treatment. Am J Med Sci 346:371-376.
37. Wang YF, Wu M, Ma BJ, et al. (2014) Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis. Braz J Med Biol Res 0:0.
38. Warndorf MG, Kurtzman JT, Bartel MJ, et al. (2011) Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol 9:705-709.
39. Yang H, Mao Y, Lu X, et al. (2011) The effects of urinary trypsin inhibitor on liver function and inflammatory factors in patients undergoing hepatectomy: a prospective, randomized, controlled clinical study. Am J Surg 202:151-157.
40. Yang QG, Luo XM, Zhang Q (2011) Clinical efficiency of ulinastatin treatment on severe acute pancreatitis. Anhui Medical and Pharmaceutical Journal 15:1147-1148.
41. Zhang A, Wang PF, Chen XD, et al. (2008a) Difference of CRP and ICAM-1 before and after the treatment in the patients with severe acute pancreatitis. Chin J Crit Care Med 28: 829-831.
42. Zhang SP (2010) Effect of ulinastatin on serum C-reactive protein in acute pancreatitis. Chin J Crit Care Med 48:7-8, 10.
43. Zhang Y, Chen H, Li YM, et al. (2008b) Thymosin alpha1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenemresistant bacteria. J Infect Dis 198:723-730.
44. Zhang ZF, Yang N, Zhao G, et al. (2010) Preventive effect of ulinastatin and gabexate mesylate on post-endoscopic retrograde cholangiopancreatography pancreatitis. Chin Med J (Engl) 123:2600-2606.
45. Zhao G, Zhu Y, Yu D, et al. (2015) The effect of ulinastatin on hyperglycemia in patients undergoing hepatectomy. J Surg Res 193:223-228.
46. Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in metaanalysis of genome searches. Genet Epidemiol 28:123-137.