Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton

Journal of Orthopaedic Research

Volumn 34, Issue 11, 2016, Pages 1914-1921

  Haffner Luntzer, Melanie ^a   Heilmann, Aline ^a   Heidler, Verena ^a   Liedert, Astrid ^a   Schinke, Thorsten ^b   Amling, Michael ^b   Yorgan, Timur Alexander ^b   vom Scheidt, Annika ^b   Ignatius, Anita ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

calcium malabsorption; calcium supplementation; fracture healing; hypochlorhydria; post traumatic bone loss

Indexed keywords

CALCIUM; GLUCONATE CALCIUM; PARATHYROID HORMONE; CHOLECYSTOKININ B RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE MASS; BONE TURNOVER; CALCIUM ABSORPTION; CALCIUM MOBILIZATION; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMUR OSTEOTOMY; FRACTURE HEALING; GASTRIC HYPOACIDITY; MALABSORPTION; MICRO-COMPUTED TOMOGRAPHY; MINERALIZATION; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; SKELETON; STOMACH PARIETAL CELL; ACHLORHYDRIA; ANIMAL; COMPLICATION; DIETARY SUPPLEMENT; ELECTROLYTE DISTURBANCE; ETIOLOGY; FEMALE; FEMUR FRACTURE; GENETICS; METABOLISM; PATHOPHYSIOLOGY; RANDOMIZATION;

ACHLORHYDRIA; ANIMALS; BONE RESORPTION; CALCIUM; CALCIUM METABOLISM DISORDERS; DIETARY SUPPLEMENTS; FEMALE; FEMORAL FRACTURES; FRACTURE HEALING; MICE; RANDOM ALLOCATION; RECEPTOR, CHOLECYSTOKININ B;

EID: 84960871725     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.23221     Document Type: Article

References (39)

1. Straub DA. 2007. Calcium supplementation in clinical practice: a review of forms, doses, and indications. Nutr Clin Pract 22:286–296.
2. Weerapol Y, Cheewatanakornkool K, Sriamornsak P. 2010. Impact of gastric pH and dietary fiber on calcium availability of various calcium salts. Silpakorn Univ Sci Technol J 4:15–23.
3. Yang YX, Lewis JD, Epstein S, et al. 2006. Long-term proton pump inhibitor therapy and risk of hip fracture. J Am Med Assoc 296:2947–2953.
4. Chiu HF, Huang YW, Chang CC, et al. 2010. Use of proton pump inhibitors increased the risk of hip fracture: a population-based case-control study. Pharmacoepidemiol Drug Saf 19:1131–1136.
5. Adachi Y, Shiota E, Matsumata T, et al. 2000. Osteoporosis after gastrectomy: bone mineral density of lumbar spine assessed by dual-energy X-ray absorptiometry. Calcif Tissue Int 66:119–122.
6. Lim JS, Kim SB, Bang HY, et al. 2007. High prevalence of osteoporosis in patients with gastric adenocarcinoma following gastrectomy. World J Gastroenterol 13:6492–6497.
7. Krause M, Keller J, Beil B, et al. Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int 26:987–995.
8. Schinke T, Schilling AF, Baranowsky A, et al. 2009. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med 15:674–681.
9. Dockray G, Dimaline R, Varro A. 2005. Gastrin: old hormone, new functions. Pflugers Arch 449:344–355.
10. Langhans N, Rindi G, Chiu M, et al. 1997. Abnormal gastric histology and decreased acid production in cholecystokinin-B/gastrin receptor-deficient mice. Gastroenterology 112:280–286.
11. Fossmark R, Stunes AK, Petzold C, et al. 2012. Decreased bone mineral density and reduced bone quality in H(+) /K(+) ATPase beta-subunit deficient mice. J Cell Biochem 113:141–147.
12. Bauer GC. 1954. Rate of bone salt formation in a healing fracture determined in rats by means of radiocalcium. Acta Orthop Scand 23:169–191.
13. Herman H, Richelle L. 1961. Exchangeable calcium of the mineral substance of bone studied with the aid of Ca45. VII. Comparative activity of the fractions of total bone with different densities. Bull Soc Chim Biol (Paris) 43:273–282.
14. Lemaire RG. 1966. Calcium metabolism in fracture healing. An experimental kinetic study in rats, using Ca45. J Bone Joint Surg Am 48:1156–1170.
15. de Vries F, Cooper AL, Cockle SM, et al. 2009. Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates. Osteoporos Int 20:1989–1998.
16. Haffner-Luntzer M, Heilmann A, Rapp AE. 2014. Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. PLoS ONE 9:e116282.
17. Heilmann A, Schinke T, Bindl R. 2013. Systemic treatment with the sphingosine-1-phosphate analog FTY720 does not improve fracture healing in mice. J Orthop Res 31:1845–1850.
18. Rontgen V, Blakytny R, Matthys R. 2010. Fracture healing in mice under controlled rigid and flexible conditions using an adjustable external fixator. J Orthop Res 28:1456–1462.
19. Morgan EF, Mason ZD, Chien KB. 2009. Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone 44:335–344.
20. Busse B, Hahn M, Soltau M, et al. 2009. Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone 45:1034–1043.
21. Roschger P, Fratzl P, Eschberger J, et al. 1998. Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319–326.
22. Roschger P, Plenk H Jr., Klaushofer K, et al. 1995. A new scanning electron microscopy approach to the quantification of bone mineral distribution: backscattered electron image grey-levels correlated to calcium K alpha-line intensities. Scanning Microsc 9:75–86.
23. Aoki K, Kihaile PE, Wenyuan Z, et al. 2005. Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. Ann Epidemiol 15:598–606.
24. Doepfner W. 1970. Consequences of calcium and-or phosphorus deficient diets on various parameters of callus formation and on growth rate in young rats. Br J Pharmacol 39:188P–189P.
25. Namkung-Matthai H, Appleyard R, Jansen J, et al. 2001. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 28:80–86.
26. Christiansen P. 2001. The skeleton in primary hyperparathyroidism: a review focusing on bone remodeling, structure, mass, and fracture. APMIS Suppl 102:1–52.
27. Haldimann B, Bonjour JP, Fleisch H. 1977. Role of parathyroid hormone in regulation of main calcium fluxes in rats. Am J Physiol 232:E535–E541.
28. Huang JC, Sakata T, Pfleger LL, et al. 2004. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res 19:235–244.
29. Parfitt AM. 1976. The actions of parathyroid hormone on bone: relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part IV of IV parts: the state of the bones in uremic hyperaparathyroidism—the mechanisms of skeletal resistance to PTH in renal failure and pseudohypoparathyroidism and the role of PTH in osteoporosis, osteopetrosis, and osteofluorosis. Metabolism 25:1157–1188.
30. D'Adamo CR, Hawkes WG, Miller RR, et al. 2014. Short-term changes in body composition after surgical repair of hip fracture. Age Ageing 43:275–280.
31. Fox KM, Magaziner J, Hawkes WG, et al. 2000. Loss of bone density and lean body mass after hip fracture. Osteoporos Int 11:31–35.
32. Meller Y, Kestenbaum RS, Mozes M, et al. 1984. Mineral and endocrine metabolism during fracture healing in dogs. Clin Orthop Relat Res 187:289–295.
33. Hardy JR, Conlan D, Hay S, et al. 1993. Serum ionised calcium and its relationship to parathyroid hormone after tibial fracture. J Bone Joint Surg Br 75:645–649.
34. Lane JM, Healey JH, Schwartz E, et al. 1984. Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry. Orthop Clin North Am 15:729–745.
35. Yu-Yahiro JA, Michael RH, Dubin NH, et al. 2001. Serum and urine markers of bone metabolism during the year after hip fracture. J Am Geriatr Soc 49:877–883.
36. Ahmed LA, Center JR, Bjornerem A, et al. 2013. Progressively increasing fracture risk with advancing age after initial incident fragility fracture: the Tromso study. J Bone Miner Res 28:2214–2221.
37. Lyles KW, Schenck AP, Colon-Emeric CS. 2008. Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int 19:1225–1233.
38. Shuid AN, Mohamad S, Mohamed N, et al. 2010. Effects of calcium supplements on fracture healing in a rat osteoporotic model. J Orthop Res 28:1651–1656.
39. Aslan BKA, Bozlar M, Atik E, et al. 2006. Effects of vitamin D3 and calcium on fracture healing in rats. Turkiye Klinikleri J Med Sci 26:507–513.