Common polymorphisms at the CYP17A1 locus associate with steroid phenotype: Support for blood pressure genome-wide association study signals at this locus

Hypertension

Volumn 67, Issue 4, 2016, Pages 724-732

  Diver, Louise A ^a   MacKenzie, Scott M ^a   Fraser, Robert ^a   McManus, Frances ^a   Freel, E Marie ^a   Alvarez Madrazo, Samantha ^a   McClure, John D ^a   Friel, Elaine C ^a   Hanley, Neil A ^b   Dominiczak, Anna F ^a   Caulfield, Mark J ^c   Munroe, Patricia B ^c   Connell, John M ^d   Davies, Eleanor ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

aldosterone; blood pressure; genome wide association study; hypertension; polymorphism, single nucleotide

Indexed keywords

ALDOSTERONE; STEROID; TETRAHYDRODEOXYCORTICOSTERONE; TETRAHYDRODEOXYCORTISOL; UNCLASSIFIED DRUG; CYP17A1 PROTEIN, HUMAN; STEROID 11BETA MONOOXYGENASE; STEROID 17ALPHA MONOOXYGENASE;

ADULT; AGED; ALDOSTERONE URINE LEVEL; ARTICLE; BLOOD PRESSURE REGULATION; CYP17A1 GENE; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HYDROXYLATION; HYPERTENSION; IN VITRO STUDY; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REPORTER GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STEROID HYDROXYLATION; TRANSCRIPTION INITIATION SITE; URINARY EXCRETION; ALLELE; BLOOD PRESSURE; COHORT ANALYSIS; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; METABOLISM; MIDDLE AGED; NORMAL HUMAN; REFERENCE VALUE; REGULATOR GENE;

ADULT; AGED; ALDOSTERONE; ALLELES; BLOOD PRESSURE; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HEALTHY VOLUNTEERS; HUMANS; HYPERTENSION; LOCUS CONTROL REGION; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE;

EID: 84960797759     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.06925     Document Type: Article

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