Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
Fujikawa T, Berglund ED, Patel VR, et al. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013;18:431-444.
Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling
Denroche HC, Levi J, Wideman RD, et al. Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes. 2011;60:1414-1423.
Leptin activates a novel CNS mechanism for insulin-independent normalizationofsevere diabetic hyperglycemia
German JP, Thaler JP, Wisse BE, et al. Leptin activates a novel CNS mechanism for insulin-independent normalizationofsevere diabetic hyperglycemia. Endocrinology. 2011;152:394-404.
Making insulindeficient type 1 diabetic rodents thrive without insulin
Yu X, Park BH, Wang MY, Wang ZV, Unger RH. Making insulindeficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci USA. 2008;105:14070-14075.
Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol
Denroche HC, Kwon MM, Quong WL, et al. Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol. Diabetologia. 2015;58:1100-1108.
Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice
Fujikawa T, Chuang JC, Sakata I, Ramadori G, Coppari R. Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice. Proc Natl Acad Sci USA. 2010;107:17391-17396.