E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Ma, Shuangtao ^a   Tian, Xiao Yu ^a,b   Zhang, Yunrong ^a   Mu, Chaofeng ^a   Shen, Haifa ^a   Bismuth, Jean ^c   Pownall, Henry J ^a   Huang, Yu ^b   Wong, Wing Tak ^a  

^a HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DRUG CARRIER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MICRORNA; NANOPARTICLE;

ANIMAL; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; C57BL MOUSE; DISEASE MODEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; PATHOLOGY; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; E-SELECTIN; INJECTIONS, INTRAVENOUS; MALE; MICE, INBRED C57BL; MICRORNAS; NANOPARTICLES; PLAQUE, ATHEROSCLEROTIC; TREATMENT OUTCOME;

EID: 84960510003     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22910     Document Type: Article

References (46)

1. Libby P., Ridker P. M., & Maseri A. Inflammation and atherosclerosis. Circulation 105, 1135-1143 (2002
2. VanderLaan P. A., Reardon C. A., & Getz G. S. Site specificity of atherosclerosis: site-selective responses to atherosclerotic modulators. Arterioscler Thromb Vasc Biol 24, 12-22 (2004
3. Ha M., & Kim V. N. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol 15, 509-524 (2014
4. Neth P., Nazari-Jahantigh M., Schober A., & Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res 99, 294-303 (2013
5. Kumar S., Kim C. W., Simmons R. D., & Jo H. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs. Arterioscler Thromb Vasc Biol 34, 2206-2216 (2014
6. Qin X., et al. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci USA 107, 3240-3244 (2010
7. Wang K. C., et al. Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth. Proc Natl Acad Sci USA 107, 3234-3239 (2010
8. Fang Y., Shi C., Manduchi E., Civelek M., & Davies P. F. MicroRNA-10a regulation of proinflammatory phenotype in atherosusceptible endothelium in vivo and in vitro. Proc Natl Acad Sci USA 107, 13450-13455 (2010
9. Chen L. J., et al. MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress. Circ Res 116, 1157-1169 (2015
10. Chi Z., & Melendez A. J. Role of cell adhesion molecules and immune-cell migration in the initiation, onset and development of atherosclerosis. Cell Adh Migr 1, 171-175 (2007
11. Zhang Y., Wang Z., & Gemeinhart R. A. Progress in microRNA delivery. J Control Release 172, 962-974 (2013
12. Muthiah M., Park I. K., & Cho C. S. Nanoparticle-mediated delivery of therapeutic genes: focus on miRNA therapeutics. Expert Opin Drug Deliv 10, 1259-1273 (2013
13. Biray Avci C., Ozcan I., Balci T., Ozer O., & Gunduz C. Design of polyethylene glycol-polyethylenimine nanocomplexes as nonviral carriers: mir-150 delivery to chronic myeloid leukemia cells. Cell Biol Int 37, 1205-1214 (2013
14. Shen H., et al. Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Clin Cancer Res 19, 1806-1815 (2013
15. Mai J., et al. Bone marrow endothelium-targeted therapeutics for metastatic breast cancer. J Control Release 187, 22-29 (2014
16. Shen H., et al. Cooperative, nanoparticle-enabled thermal therapy of breast cancer. Adv Healthc Mater 1, 84-89 (2012
17. Andrikopoulos S., Blair A. R., Deluca N., Fam B. C., & Proietto J. Evaluating the glucose tolerance test in mice. Am J Physiol Endocrinol Metab 295, E1323-1332 (2008
18. Tian X. Y., et al. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res 110, 1211-1216 (2012
19. van Rooij E., Purcell A. L., & Levin A. A. Developing microRNA therapeutics. Circ Res 110, 496-507 (2012
20. Chen Y., Gao D. Y., & Huang L. In vivo delivery of miRNAs for cancer therapy: challenges and strategies. Adv Drug Deliv Rev 81, 128-141 (2015
21. Jokerst J. V., Lobovkina T., Zare R. N., & Gambhir S. S. Nanoparticle PEGylation for imaging and therapy. Nanomedicine (Lond) 6, 715-728 (2011
22. Malam Y., Loizidou M., & Seifalian A. M. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 30, 592-599 (2009
23. Sun X., et al. Systemic delivery of microRNA-181b inhibits nuclear factor-kappaB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res 114, 32-40 (2014
24. Dong Z. M., et al. The combined role of P-and E-selectins in atherosclerosis. J Clin Invest 102, 145-152 (1998
25. Galkina E., & Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 27, 2292-2301 (2007
26. Moreno P. R., Purushothaman K. R., Sirol M., Levy A. P., & Fuster V. Neovascularization in human atherosclerosis. Circulation 113, 2245-2252 (2006
27. Jaipersad A. S., Lip G. Y., Silverman S., & Shantsila E. The role of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol 63, 1-11 (2014
28. Doyle B., & Caplice N. Plaque neovascularization and antiangiogenic therapy for atherosclerosis. J Am Coll Cardiol 49, 2073-2080 (2007
29. Zhang X. Q., et al. Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis. Adv Healthc Mater 4, 228-236 (2015
30. Lewis D. R., et al. Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo. Proc Natl Acad Sci USA 112, 2693-2698 (2015
31. Schober A., et al. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med 20, 368-376 (2014
32. Namdee K., et al. In vivo evaluation of vascular-targeted spheroidal microparticles for imaging and drug delivery application in atherosclerosis. Atherosclerosis 237, 279-286 (2014
33. Gonzalez-Rodriguez D., & Barakat A. I. Dynamics of receptor-mediated nanoparticle internalization into endothelial cells. PLoS One 10, e0122097 (2015
34. Fredman G., et al. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med 7, 275ra220 (2015
35. Hofmeister L. H., et al. Phage-display-guided nanocarrier targeting to atheroprone vasculature. ACS Nano 9, 4435-4446 (2015
36. Lobatto M. E., et al. Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS Nano 9, 1837-1847 (2015
37. Kuo C. H., et al. Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles. J Mater Chem B Mater Biol Med 2, 8142-8153 (2014
38. Kheirolomoom A., et al. Multifunctional Nanoparticles Facilitate Molecular Targeting and miRNA Delivery to Inhibit Atherosclerosis in ApoE(-/- ) Mice. ACS Nano 9, 8885-8897 (2015
39. Kharlamov A. N., et al. Silica-gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial. Nanoscale 7, 8003-8015 (2015
40. Zampetaki A., & Mayr M. MicroRNAs in vascular and metabolic disease. Circ Res 110, 508-522 (2012
41. Sun X., Belkin N., & Feinberg M. W. Endothelial microRNAs and atherosclerosis. Curr Atheroscler Rep 15, 372 (2013
42. Sun X., et al. MicroRNA-181b regulates NF-kappaB-mediated vascular inflammation. J Clin Invest 122, 1973-1990 (2012
43. Li K., Ching D., Luk F. S., Raffai R. L., & Apolipoprotein E. Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor-kappaB-Driven Inflammation and Atherosclerosis. Circ Res 117, e1-e11 (2015
44. Balasubramanyam M., et al. Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. Mol Cell Biochem 351, 197-205 (2011
45. Wang H. J., et al. MicroRNA-146a decreases high glucose/thrombin-induced endothelial inflammation by inhibiting NAPDH oxidase 4 expression. Mediators Inflamm 2014, 379537 (2014
46. Vasa-Nicotera M., et al. miR-146a is modulated in human endothelial cell with aging. Atherosclerosis 217, 326-330 (2011