메뉴 건너뛰기




Volumn 21, Issue 3, 2016, Pages 283-291

Predictive and prognostic role of tumor-infiltrating lymphocytes for early breast cancer according to disease subtypes: Sensitivity analysis of randomized trials in adjuvant and neoadjuvant setting

Author keywords

Adjuvant; Breast cancer; Neoadjuvant; Prognosis; Sensitivity analysis; Tumor infiltrating lymphocytes

Indexed keywords

ADJUVANT THERAPY; ARTICLE; BREAST CANCER; CANCER PROGNOSIS; CLINICAL ASSESSMENT; CLINICAL EVALUATION; HUMAN; IMMUNE RESPONSE; INFORMATION PROCESSING; MEDLINE; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TUMOR ASSOCIATED LEUKOCYTE; ADJUVANT CHEMOTHERAPY; DISEASE FREE SURVIVAL; FEMALE; IMMUNOLOGY; NEOADJUVANT THERAPY; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84960503302     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2015-0307     Document Type: Article
Times cited : (47)

References (52)
  • 1
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734–1736.
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 2
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252–264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 3
    • 36849010167 scopus 로고    scopus 로고
    • Adaptive immunity maintains occult cancer in an equilibrium state
    • Koebel CM, Vermi W, Swann JB et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450:903–907.
    • (2007) Nature , vol.450 , pp. 903-907
    • Koebel, C.M.1    Vermi, W.2    Swann, J.B.3
  • 4
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity’s roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011;331:1565–1570.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 5
    • 85047692172 scopus 로고    scopus 로고
    • Therapeutic vaccines for cancer: An overview of clinical trials
    • Melero I, Gaudernack G, Gerritsen W et al. Therapeutic vaccines for cancer: An overview of clinical trials. Nat Rev Clin Oncol 2014;11:509–524.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 509-524
    • Melero, I.1    Gaudernack, G.2    Gerritsen, W.3
  • 6
    • 84942899415 scopus 로고    scopus 로고
    • The evolution of T-cell therapies for solid malignancies
    • Fousek K, Ahmed N. The evolution of T-cell therapies for solid malignancies. Clin Cancer Res 2015;21:3384–3392.
    • (2015) Clin Cancer Res , vol.21 , pp. 3384-3392
    • Fousek, K.1    Ahmed, N.2
  • 7
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004;4:11–22.
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 8
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O’Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl JMed 2010;363:711–723.
    • (2010) N Engl Jmed , vol.363 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3
  • 9
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • Rizvi NA, Mazières J, Planchard D et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial. Lancet Oncol 2015;16:257–265.
    • (2015) Lancet Oncol , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazières, J.2    Planchard, D.3
  • 10
    • 84908354848 scopus 로고    scopus 로고
    • Antiprogrammed- death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD et al. Antiprogrammed- death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet 2014;384:1109–1117.
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 11
    • 84924076132 scopus 로고    scopus 로고
    • International TILsWorking Group 2014.The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: Recommendations by an International TILs Working Group 2014
    • Salgado R, Denkert C, Demaria S et al; International TILsWorking Group 2014.The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol 2015;26:259–271.
    • (2015) Ann Oncol , vol.26 , pp. 259-271
    • Salgado, R.1    Denkert, C.2    Demaria, S.3
  • 12
    • 0026510591 scopus 로고
    • Lymphocyte infiltrates as a prognostic variable in female breast cancer
    • Aaltomaa S, Lipponen P, Eskelinen M et al. Lymphocyte infiltrates as a prognostic variable in female breast cancer. Eur J Cancer 1992;28A: 859–864.
    • (1992) Eur J Cancer , vol.28A , pp. 859-864
    • Aaltomaa, S.1    Lipponen, P.2    Eskelinen, M.3
  • 13
    • 1842338058 scopus 로고    scopus 로고
    • Lymphoid infiltration as a prognostic variable for early-onset breastcarcinomas
    • Ménard S, Tomasic G, Casalini P et al. Lymphoid infiltration as a prognostic variable for early-onset breastcarcinomas. Clin Cancer Res1997;3:817–819.
    • Clin Cancer Res1997 , vol.3 , pp. 817-819
    • Ménard, S.1    Tomasic, G.2    Casalini, P.3
  • 14
    • 84865418286 scopus 로고    scopus 로고
    • The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer
    • Mohammed ZM, Going JJ, Edwards J et al. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Br J Cancer 2012;107:864–873.
    • (2012) Br J Cancer , vol.107 , pp. 864-873
    • Mohammed, Z.M.1    Going, J.J.2    Edwards, J.3
  • 15
    • 79956329617 scopus 로고    scopus 로고
    • Tumorinfiltrating CD81 lymphocytes predict clinical outcome in breast cancer
    • Mahmoud SM, Paish EC, Powe DG et al. Tumorinfiltrating CD81 lymphocytes predict clinical outcome in breast cancer. J Clin Oncol 2011;29:1949–1955.
    • (2011) J Clin Oncol , vol.29 , pp. 1949-1955
    • Mahmoud, S.M.1    Paish, E.C.2    Powe, D.G.3
  • 16
    • 84907198355 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating lymphocytes in triplenegative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199
    • Adams S, Gray RJ, Demaria S et al. Prognostic value of tumor-infiltrating lymphocytes in triplenegative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol 2014;32:2959–2966.
    • (2014) J Clin Oncol , vol.32 , pp. 2959-2966
    • Adams, S.1    Gray, R.J.2    Demaria, S.3
  • 17
    • 84905178989 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial
    • Loi S, Michiels S, Salgado R et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial. Ann Oncol 2014;25:1544–1550.
    • (2014) Ann Oncol , vol.25 , pp. 1544-1550
    • Loi, S.1    Michiels, S.2    Salgado, R.3
  • 18
    • 84875722651 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breastcancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicinwith doxorubicinbased chemotherapy: BIG 02-98
    • Loi S, Sirtaine N, Piette F et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breastcancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicinwith doxorubicinbased chemotherapy: BIG 02-98. J ClinOncol 2013;31: 860–867.
    • (2013) J Clinoncol , vol.31 , pp. 860-867
    • Loi, S.1    Sirtaine, N.2    Piette, F.3
  • 19
    • 84912011347 scopus 로고    scopus 로고
    • The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: A meta-analysis
    • Ibrahim EM, Al-Foheidi ME, Al-Mansour MM et al. The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: A meta-analysis. Breast Cancer Res Treat 2014;148: 467–476.
    • (2014) Breast Cancer Res Treat , vol.148 , pp. 467-476
    • Ibrahim, E.M.1    Al-Foheidi, M.E.2    Al-Mansour, M.M.3
  • 20
    • 84904188903 scopus 로고    scopus 로고
    • Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis
    • Cortazar P, Zhang L, Untch M et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2014;384:164–172.
    • (2014) Lancet , vol.384 , pp. 164-172
    • Cortazar, P.1    Zhang, L.2    Untch, M.3
  • 21
    • 73949092850 scopus 로고    scopus 로고
    • Tumorassociated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
    • Denkert C, Loibl S, Noske A et al. Tumorassociated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol 2010;28:105–113.
    • (2010) J Clin Oncol , vol.28 , pp. 105-113
    • Denkert, C.1    Loibl, S.2    Noske, A.3
  • 22
    • 84891590308 scopus 로고    scopus 로고
    • Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer–a substudy of the neoadjuvant Gepar Quinto trial
    • Issa-Nummer Y, Darb-Esfahani S, Loibl S et al. Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer–a substudy of the neoadjuvant Gepar Quinto trial. PLoS One 2013;8:e79775.
    • (2013) Plos One , vol.8
    • Issa-Nummer, Y.1    Darb-Esfahani, S.2    Loibl, S.3
  • 23
    • 84927138902 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin inhumanepidermal growth factor receptor 2- positive and triple-negative primary breast cancers
    • Denkert C, von Minckwitz G, Brase JC et al. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin inhumanepidermal growth factor receptor 2- positive and triple-negative primary breast cancers. J Clin Oncol 2015;33:983–991.
    • (2015) J Clin Oncol , vol.33 , pp. 983-991
    • Denkert, C.1    Von Minckwitz, G.2    Brase, J.C.3
  • 24
    • 84918537575 scopus 로고    scopus 로고
    • The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer:Asystematic reviewand meta-analysis
    • Mao Y, Qu Q, Zhang Y et al. The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer:Asystematic reviewand meta-analysis. PLoS One 2014;9:e115103.
    • (2014) Plos One , vol.9
    • Mao, Y.1    Qu, Q.2    Zhang, Y.3
  • 25
    • 0035436432 scopus 로고    scopus 로고
    • Meta-analyses of randomised clinical trials in oncology
    • Pignon JP, Hill C. Meta-analyses of randomised clinical trials in oncology. Lancet Oncol 2001;2: 475–482.
    • (2001) Lancet Oncol , vol.2 , pp. 475-482
    • Pignon, J.P.1    Hill, C.2
  • 26
    • 57649109776 scopus 로고    scopus 로고
    • Magnitude of benefit of adjuvant chemotherapy for nonsmall cell lung cancer: Meta-analysis of randomized clinical trials
    • Bria E, Gralla RJ, Raftopoulos H et al. Magnitude of benefit of adjuvant chemotherapy for nonsmall cell lung cancer: meta-analysis of randomized clinical trials. Lung Cancer 2009;63:50–57.
    • (2009) Lung Cancer , vol.63 , pp. 50-57
    • Bria, E.1    Gralla, R.J.2    Raftopoulos, H.3
  • 28
    • 84921702413 scopus 로고    scopus 로고
    • Interaction revisited: The difference between two estimates
    • Altman DG, Bland JM. Interaction revisited: The difference between two estimates. BMJ 2003; 326:219.
    • (2003) BMJ , vol.326 , pp. 219
    • Altman, D.G.1    Bland, J.M.2
  • 29
    • 84897571862 scopus 로고    scopus 로고
    • Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials
    • Pilotto S, Di Maio M, Peretti U et al. Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials. Crit Rev Oncol Hematol 2014;90: 135–145.
    • (2014) Crit Rev Oncol Hematol , vol.90 , pp. 135-145
    • Pilotto, S.1    Di Maio, M.2    Peretti, U.3
  • 30
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815–2834.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 31
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • Tierney JF, Stewart LA, Ghersi D et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16.
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3
  • 32
    • 80052194689 scopus 로고    scopus 로고
    • Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: A meta-analysis
    • Bria E, Milella M, Cuppone F et al. Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: A meta-analysis. Ann Oncol 2011;22: 2277–2285.
    • (2011) Ann Oncol , vol.22 , pp. 2277-2285
    • Bria, E.1    Milella, M.2    Cuppone, F.3
  • 33
    • 84960479864 scopus 로고    scopus 로고
    • Abstract PD1-1: Tumor infiltrating lymphocytes and correlation withoutcomein the Cher-LOB study
    • Dieci MV, Bisagni G, Cagossi K et al. Abstract PD1-1: Tumor infiltrating lymphocytes and correlation withoutcomein the Cher-LOB study. Cancer Res 2015;75: PD1–PD1.
    • (2015) Cancer Res , vol.75
    • Dieci, M.V.1    Bisagni, G.2    Cagossi, K.3
  • 34
    • 84941623486 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials
    • Dieci MV, Mathieu MC, Guarneri V et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials. AnnOncol 2015;26:1698–1704.
    • (2015) Annoncol , vol.26 , pp. 1698-1704
    • Dieci, M.V.1    Mathieu, M.C.2    Guarneri, V.3
  • 36
    • 84867116994 scopus 로고    scopus 로고
    • Understanding the biology of triple-negative breast cancer
    • Criscitiello C, Azim HA Jr., Schouten PC et al. Understanding the biology of triple-negative breast cancer. Ann Oncol 2012;23(suppl 6): vi13–vi18.
    • (2012) Ann Oncol , vol.23
    • Criscitiello, C.1    Azim, H.A.2    Schouten, P.C.3
  • 37
    • 84919383828 scopus 로고    scopus 로고
    • Subtyping of triple-negative breast cancer: Implications for therapy
    • Abramson VG, Lehmann BD, Ballinger TJ et al. Subtyping of triple-negative breast cancer: Implications for therapy. Cancer 2015;121:8–16.
    • (2015) Cancer , vol.121 , pp. 8-16
    • Abramson, V.G.1    Lehmann, B.D.2    Ballinger, T.J.3
  • 38
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750–2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3
  • 39
    • 84868240146 scopus 로고    scopus 로고
    • Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation
    • Popova T, Manié E, Rieunier G et al. Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. Cancer Res 2012;72:5454–5462.
    • (2012) Cancer Res , vol.72 , pp. 5454-5462
    • Popova, T.1    Manié, E.2    Rieunier, G.3
  • 40
    • 84933181457 scopus 로고    scopus 로고
    • Role of inflammatory infiltrates in triple negative breast cancer
    • Matsumoto H, Koo SL, Dent R et al. Role of inflammatory infiltrates in triple negative breast cancer. J Clin Pathol 2015;68:506–510.
    • (2015) J Clin Pathol , vol.68 , pp. 506-510
    • Matsumoto, H.1    Koo, S.L.2    Dent, R.3
  • 41
    • 50649115738 scopus 로고    scopus 로고
    • Cancer chemotherapy: Not only adirect cytotoxic effect, but also an adjuvant for antitumor immunity
    • Ménard C, Martin F, Apetoh L et al. Cancer chemotherapy: not only adirect cytotoxic effect, but also an adjuvant for antitumor immunity. Cancer Immunol Immunother 2008;57:1579–1587.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 1579-1587
    • Ménard, C.1    Martin, F.2    Apetoh, L.3
  • 42
    • 42249115188 scopus 로고    scopus 로고
    • Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp31 regulatory T cells
    • Ladoire S, Arnould L, Apetoh L et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp31 regulatory T cells. Clin Cancer Res 2008;14:2413–2420.
    • (2008) Clin Cancer Res , vol.14 , pp. 2413-2420
    • Ladoire, S.1    Arnould, L.2    Apetoh, L.3
  • 43
    • 2542421791 scopus 로고    scopus 로고
    • Cellular immunity in breast cancer patients completing taxane treatment
    • Carson WE 3rd, Shapiro CL, Crespin TR et al. Cellular immunity in breast cancer patients completing taxane treatment. Clin Cancer Res 2004;10: 3401–3409.
    • (2004) Clin Cancer Res , vol.10 , pp. 3401-3409
    • Carson, W.E.1    Shapiro, C.L.2    Crespin, T.R.3
  • 45
    • 84895779425 scopus 로고    scopus 로고
    • PD-L1 expression is increased in a subset of basal type breast cancer cells
    • Soliman H, Khalil F, Antonia S. PD-L1 expression is increased in a subset of basal type breast cancer cells. PLoS One 2014;9:e88557.
    • (2014) Plos One , vol.9
    • Soliman, H.1    Khalil, F.2    Antonia, S.3
  • 46
    • 84939227614 scopus 로고    scopus 로고
    • Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
    • Carbognin L, Pilotto S, Milella M et al. differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS One 2015;10: e0130142.
    • (2015) Plos One , vol.10
    • Carbognin, L.1    Pilotto, S.2    Milella, M.3
  • 47
    • 84937961692 scopus 로고    scopus 로고
    • Abstract S1- 09:Aphase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer
    • Nanda R, Chow LQ, Dees EC et al. Abstract S1- 09:Aphase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. Cancer Res 2015;75:S1–S09.
    • (2015) Cancer Res , vol.75
    • Nanda, R.1    Chow, L.Q.2    Dees, E.C.3
  • 48
    • 84944041240 scopus 로고    scopus 로고
    • Abstract PD1-6: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triplenegative breast cancer
    • Emens LA, Braiteh FS, Cassier P et al. Abstract PD1-6: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triplenegative breast cancer. Cancer Res 2015;75:PD1-6.
    • (2015) Cancer Res , vol.75
    • Emens, L.A.1    Braiteh, F.S.2    Cassier, P.3
  • 49
    • 84977962630 scopus 로고    scopus 로고
    • ClinicalTrials.gov. http://www.clinicaltrials.gov.
  • 50
    • 84940441772 scopus 로고    scopus 로고
    • Abstract S1-06: Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit
    • Perez EA, Ballman KV, Anderson SK et al. Abstract S1-06: Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit. Cancer Res 2015;75: S1–S06.
    • (2015) Cancer Res , vol.75
    • Perez, E.A.1    Ballman, K.V.2    Erson, S.K.3
  • 51
    • 84892959147 scopus 로고    scopus 로고
    • The immune system and response to HER2-targeted treatment in breast cancer
    • Bianchini G, Gianni L.The immune system and response to HER2-targeted treatment in breast cancer. Lancet Oncol 2014;15:e58–e68.
    • (2014) Lancet Oncol , vol.15
    • Bianchini, G.1    Gianni, L.2
  • 52
    • 84982889739 scopus 로고    scopus 로고
    • Tumorinfiltrating lymphocytes and associations with pathological complete response and event-free survival in HER2-positive early-stage breast cancer treated with lapatinib and trastuzumab: A secondary analysis of the NeoALTTO Trial
    • Salgado R, Denkert C, Campbell C et al. Tumorinfiltrating lymphocytes and associations with pathological complete response and event-free survival in HER2-positive early-stage breast cancer treated with lapatinib and trastuzumab: A secondary analysis of the NeoALTTO Trial. JAMA Oncol 2015;1:448–454.
    • (2015) JAMA Oncol , vol.1 , pp. 448-454
    • Salgado, R.1    Denkert, C.2    Campbell, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.