-
1
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science 1996;271:1734–1736.
-
(1996)
Science
, vol.271
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
2
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252–264.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
3
-
-
36849010167
-
Adaptive immunity maintains occult cancer in an equilibrium state
-
Koebel CM, Vermi W, Swann JB et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature 2007;450:903–907.
-
(2007)
Nature
, vol.450
, pp. 903-907
-
-
Koebel, C.M.1
Vermi, W.2
Swann, J.B.3
-
4
-
-
79953151458
-
Cancer immunoediting: Integrating immunity’s roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011;331:1565–1570.
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
5
-
-
85047692172
-
Therapeutic vaccines for cancer: An overview of clinical trials
-
Melero I, Gaudernack G, Gerritsen W et al. Therapeutic vaccines for cancer: An overview of clinical trials. Nat Rev Clin Oncol 2014;11:509–524.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 509-524
-
-
Melero, I.1
Gaudernack, G.2
Gerritsen, W.3
-
6
-
-
84942899415
-
The evolution of T-cell therapies for solid malignancies
-
Fousek K, Ahmed N. The evolution of T-cell therapies for solid malignancies. Clin Cancer Res 2015;21:3384–3392.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3384-3392
-
-
Fousek, K.1
Ahmed, N.2
-
7
-
-
0347302952
-
Cytokines in cancer pathogenesis and cancer therapy
-
Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004;4:11–22.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 11-22
-
-
Dranoff, G.1
-
8
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O’Day SJ, McDermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl JMed 2010;363:711–723.
-
(2010)
N Engl Jmed
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
-
9
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
-
Rizvi NA, Mazières J, Planchard D et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial. Lancet Oncol 2015;16:257–265.
-
(2015)
Lancet Oncol
, vol.16
, pp. 257-265
-
-
Rizvi, N.A.1
Mazières, J.2
Planchard, D.3
-
10
-
-
84908354848
-
Antiprogrammed- death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchok JD et al. Antiprogrammed- death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet 2014;384:1109–1117.
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
-
11
-
-
84924076132
-
International TILsWorking Group 2014.The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: Recommendations by an International TILs Working Group 2014
-
Salgado R, Denkert C, Demaria S et al; International TILsWorking Group 2014.The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol 2015;26:259–271.
-
(2015)
Ann Oncol
, vol.26
, pp. 259-271
-
-
Salgado, R.1
Denkert, C.2
Demaria, S.3
-
12
-
-
0026510591
-
Lymphocyte infiltrates as a prognostic variable in female breast cancer
-
Aaltomaa S, Lipponen P, Eskelinen M et al. Lymphocyte infiltrates as a prognostic variable in female breast cancer. Eur J Cancer 1992;28A: 859–864.
-
(1992)
Eur J Cancer
, vol.28A
, pp. 859-864
-
-
Aaltomaa, S.1
Lipponen, P.2
Eskelinen, M.3
-
13
-
-
1842338058
-
Lymphoid infiltration as a prognostic variable for early-onset breastcarcinomas
-
Ménard S, Tomasic G, Casalini P et al. Lymphoid infiltration as a prognostic variable for early-onset breastcarcinomas. Clin Cancer Res1997;3:817–819.
-
Clin Cancer Res1997
, vol.3
, pp. 817-819
-
-
Ménard, S.1
Tomasic, G.2
Casalini, P.3
-
14
-
-
84865418286
-
The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer
-
Mohammed ZM, Going JJ, Edwards J et al. The relationship between components of tumour inflammatory cell infiltrate and clinicopathological factors and survival in patients with primary operable invasive ductal breast cancer. Br J Cancer 2012;107:864–873.
-
(2012)
Br J Cancer
, vol.107
, pp. 864-873
-
-
Mohammed, Z.M.1
Going, J.J.2
Edwards, J.3
-
15
-
-
79956329617
-
Tumorinfiltrating CD81 lymphocytes predict clinical outcome in breast cancer
-
Mahmoud SM, Paish EC, Powe DG et al. Tumorinfiltrating CD81 lymphocytes predict clinical outcome in breast cancer. J Clin Oncol 2011;29:1949–1955.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1949-1955
-
-
Mahmoud, S.M.1
Paish, E.C.2
Powe, D.G.3
-
16
-
-
84907198355
-
Prognostic value of tumor-infiltrating lymphocytes in triplenegative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199
-
Adams S, Gray RJ, Demaria S et al. Prognostic value of tumor-infiltrating lymphocytes in triplenegative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol 2014;32:2959–2966.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2959-2966
-
-
Adams, S.1
Gray, R.J.2
Demaria, S.3
-
17
-
-
84905178989
-
Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial
-
Loi S, Michiels S, Salgado R et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial. Ann Oncol 2014;25:1544–1550.
-
(2014)
Ann Oncol
, vol.25
, pp. 1544-1550
-
-
Loi, S.1
Michiels, S.2
Salgado, R.3
-
18
-
-
84875722651
-
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breastcancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicinwith doxorubicinbased chemotherapy: BIG 02-98
-
Loi S, Sirtaine N, Piette F et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breastcancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicinwith doxorubicinbased chemotherapy: BIG 02-98. J ClinOncol 2013;31: 860–867.
-
(2013)
J Clinoncol
, vol.31
, pp. 860-867
-
-
Loi, S.1
Sirtaine, N.2
Piette, F.3
-
19
-
-
84912011347
-
The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: A meta-analysis
-
Ibrahim EM, Al-Foheidi ME, Al-Mansour MM et al. The prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancer: A meta-analysis. Breast Cancer Res Treat 2014;148: 467–476.
-
(2014)
Breast Cancer Res Treat
, vol.148
, pp. 467-476
-
-
Ibrahim, E.M.1
Al-Foheidi, M.E.2
Al-Mansour, M.M.3
-
20
-
-
84904188903
-
Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis
-
Cortazar P, Zhang L, Untch M et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet 2014;384:164–172.
-
(2014)
Lancet
, vol.384
, pp. 164-172
-
-
Cortazar, P.1
Zhang, L.2
Untch, M.3
-
21
-
-
73949092850
-
Tumorassociated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
-
Denkert C, Loibl S, Noske A et al. Tumorassociated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol 2010;28:105–113.
-
(2010)
J Clin Oncol
, vol.28
, pp. 105-113
-
-
Denkert, C.1
Loibl, S.2
Noske, A.3
-
22
-
-
84891590308
-
Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer–a substudy of the neoadjuvant Gepar Quinto trial
-
Issa-Nummer Y, Darb-Esfahani S, Loibl S et al. Prospective validation of immunological infiltrate for prediction of response to neoadjuvant chemotherapy in HER2-negative breast cancer–a substudy of the neoadjuvant Gepar Quinto trial. PLoS One 2013;8:e79775.
-
(2013)
Plos One
, vol.8
-
-
Issa-Nummer, Y.1
Darb-Esfahani, S.2
Loibl, S.3
-
23
-
-
84927138902
-
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin inhumanepidermal growth factor receptor 2- positive and triple-negative primary breast cancers
-
Denkert C, von Minckwitz G, Brase JC et al. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin inhumanepidermal growth factor receptor 2- positive and triple-negative primary breast cancers. J Clin Oncol 2015;33:983–991.
-
(2015)
J Clin Oncol
, vol.33
, pp. 983-991
-
-
Denkert, C.1
Von Minckwitz, G.2
Brase, J.C.3
-
24
-
-
84918537575
-
The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer:Asystematic reviewand meta-analysis
-
Mao Y, Qu Q, Zhang Y et al. The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer:Asystematic reviewand meta-analysis. PLoS One 2014;9:e115103.
-
(2014)
Plos One
, vol.9
-
-
Mao, Y.1
Qu, Q.2
Zhang, Y.3
-
25
-
-
0035436432
-
Meta-analyses of randomised clinical trials in oncology
-
Pignon JP, Hill C. Meta-analyses of randomised clinical trials in oncology. Lancet Oncol 2001;2: 475–482.
-
(2001)
Lancet Oncol
, vol.2
, pp. 475-482
-
-
Pignon, J.P.1
Hill, C.2
-
26
-
-
57649109776
-
Magnitude of benefit of adjuvant chemotherapy for nonsmall cell lung cancer: Meta-analysis of randomized clinical trials
-
Bria E, Gralla RJ, Raftopoulos H et al. Magnitude of benefit of adjuvant chemotherapy for nonsmall cell lung cancer: meta-analysis of randomized clinical trials. Lung Cancer 2009;63:50–57.
-
(2009)
Lung Cancer
, vol.63
, pp. 50-57
-
-
Bria, E.1
Gralla, R.J.2
Raftopoulos, H.3
-
28
-
-
84921702413
-
Interaction revisited: The difference between two estimates
-
Altman DG, Bland JM. Interaction revisited: The difference between two estimates. BMJ 2003; 326:219.
-
(2003)
BMJ
, vol.326
, pp. 219
-
-
Altman, D.G.1
Bland, J.M.2
-
29
-
-
84897571862
-
Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials
-
Pilotto S, Di Maio M, Peretti U et al. Predictors of outcome for patients with lung adenocarcinoma carrying the epidermal growth factor receptor mutation receiving 1st-line tyrosine kinase inhibitors: Sensitivity and meta-regression analysis of randomized trials. Crit Rev Oncol Hematol 2014;90: 135–145.
-
(2014)
Crit Rev Oncol Hematol
, vol.90
, pp. 135-145
-
-
Pilotto, S.1
Di Maio, M.2
Peretti, U.3
-
30
-
-
0032583387
-
Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
-
Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 1998;17:2815–2834.
-
(1998)
Stat Med
, vol.17
, pp. 2815-2834
-
-
Parmar, M.K.1
Torri, V.2
Stewart, L.3
-
31
-
-
34547450763
-
Practical methods for incorporating summary time-to-event data into meta-analysis
-
Tierney JF, Stewart LA, Ghersi D et al. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16.
-
(2007)
Trials
, vol.8
, pp. 16
-
-
Tierney, J.F.1
Stewart, L.A.2
Ghersi, D.3
-
32
-
-
80052194689
-
Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: A meta-analysis
-
Bria E, Milella M, Cuppone F et al. Outcome of advanced NSCLC patients harboring sensitizing EGFR mutations randomized to EGFR tyrosine kinase inhibitors or chemotherapy as first-line treatment: A meta-analysis. Ann Oncol 2011;22: 2277–2285.
-
(2011)
Ann Oncol
, vol.22
, pp. 2277-2285
-
-
Bria, E.1
Milella, M.2
Cuppone, F.3
-
33
-
-
84960479864
-
Abstract PD1-1: Tumor infiltrating lymphocytes and correlation withoutcomein the Cher-LOB study
-
Dieci MV, Bisagni G, Cagossi K et al. Abstract PD1-1: Tumor infiltrating lymphocytes and correlation withoutcomein the Cher-LOB study. Cancer Res 2015;75: PD1–PD1.
-
(2015)
Cancer Res
, vol.75
-
-
Dieci, M.V.1
Bisagni, G.2
Cagossi, K.3
-
34
-
-
84941623486
-
Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials
-
Dieci MV, Mathieu MC, Guarneri V et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in two phase III randomized adjuvant breast cancer trials. AnnOncol 2015;26:1698–1704.
-
(2015)
Annoncol
, vol.26
, pp. 1698-1704
-
-
Dieci, M.V.1
Mathieu, M.C.2
Guarneri, V.3
-
36
-
-
84867116994
-
Understanding the biology of triple-negative breast cancer
-
Criscitiello C, Azim HA Jr., Schouten PC et al. Understanding the biology of triple-negative breast cancer. Ann Oncol 2012;23(suppl 6): vi13–vi18.
-
(2012)
Ann Oncol
, vol.23
-
-
Criscitiello, C.1
Azim, H.A.2
Schouten, P.C.3
-
37
-
-
84919383828
-
Subtyping of triple-negative breast cancer: Implications for therapy
-
Abramson VG, Lehmann BD, Ballinger TJ et al. Subtyping of triple-negative breast cancer: Implications for therapy. Cancer 2015;121:8–16.
-
(2015)
Cancer
, vol.121
, pp. 8-16
-
-
Abramson, V.G.1
Lehmann, B.D.2
Ballinger, T.J.3
-
38
-
-
79960015997
-
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
-
Lehmann BD, Bauer JA, Chen X et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750–2767.
-
(2011)
J Clin Invest
, vol.121
, pp. 2750-2767
-
-
Lehmann, B.D.1
Bauer, J.A.2
Chen, X.3
-
39
-
-
84868240146
-
Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation
-
Popova T, Manié E, Rieunier G et al. Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation. Cancer Res 2012;72:5454–5462.
-
(2012)
Cancer Res
, vol.72
, pp. 5454-5462
-
-
Popova, T.1
Manié, E.2
Rieunier, G.3
-
40
-
-
84933181457
-
Role of inflammatory infiltrates in triple negative breast cancer
-
Matsumoto H, Koo SL, Dent R et al. Role of inflammatory infiltrates in triple negative breast cancer. J Clin Pathol 2015;68:506–510.
-
(2015)
J Clin Pathol
, vol.68
, pp. 506-510
-
-
Matsumoto, H.1
Koo, S.L.2
Dent, R.3
-
41
-
-
50649115738
-
Cancer chemotherapy: Not only adirect cytotoxic effect, but also an adjuvant for antitumor immunity
-
Ménard C, Martin F, Apetoh L et al. Cancer chemotherapy: not only adirect cytotoxic effect, but also an adjuvant for antitumor immunity. Cancer Immunol Immunother 2008;57:1579–1587.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1579-1587
-
-
Ménard, C.1
Martin, F.2
Apetoh, L.3
-
42
-
-
42249115188
-
Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp31 regulatory T cells
-
Ladoire S, Arnould L, Apetoh L et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp31 regulatory T cells. Clin Cancer Res 2008;14:2413–2420.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2413-2420
-
-
Ladoire, S.1
Arnould, L.2
Apetoh, L.3
-
43
-
-
2542421791
-
Cellular immunity in breast cancer patients completing taxane treatment
-
Carson WE 3rd, Shapiro CL, Crespin TR et al. Cellular immunity in breast cancer patients completing taxane treatment. Clin Cancer Res 2004;10: 3401–3409.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3401-3409
-
-
Carson, W.E.1
Shapiro, C.L.2
Crespin, T.R.3
-
45
-
-
84895779425
-
PD-L1 expression is increased in a subset of basal type breast cancer cells
-
Soliman H, Khalil F, Antonia S. PD-L1 expression is increased in a subset of basal type breast cancer cells. PLoS One 2014;9:e88557.
-
(2014)
Plos One
, vol.9
-
-
Soliman, H.1
Khalil, F.2
Antonia, S.3
-
46
-
-
84939227614
-
Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
-
Carbognin L, Pilotto S, Milella M et al. differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS One 2015;10: e0130142.
-
(2015)
Plos One
, vol.10
-
-
Carbognin, L.1
Pilotto, S.2
Milella, M.3
-
47
-
-
84937961692
-
Abstract S1- 09:Aphase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer
-
Nanda R, Chow LQ, Dees EC et al. Abstract S1- 09:Aphase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. Cancer Res 2015;75:S1–S09.
-
(2015)
Cancer Res
, vol.75
-
-
Nanda, R.1
Chow, L.Q.2
Dees, E.C.3
-
48
-
-
84944041240
-
Abstract PD1-6: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triplenegative breast cancer
-
Emens LA, Braiteh FS, Cassier P et al. Abstract PD1-6: Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triplenegative breast cancer. Cancer Res 2015;75:PD1-6.
-
(2015)
Cancer Res
, vol.75
-
-
Emens, L.A.1
Braiteh, F.S.2
Cassier, P.3
-
49
-
-
84977962630
-
-
ClinicalTrials.gov. http://www.clinicaltrials.gov.
-
-
-
-
50
-
-
84940441772
-
Abstract S1-06: Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit
-
Perez EA, Ballman KV, Anderson SK et al. Abstract S1-06: Stromal tumor-infiltrating lymphocytes(S-TILs): In the alliance N9831 trial S-TILs are associated with chemotherapy benefit but not associated with trastuzumab benefit. Cancer Res 2015;75: S1–S06.
-
(2015)
Cancer Res
, vol.75
-
-
Perez, E.A.1
Ballman, K.V.2
Erson, S.K.3
-
51
-
-
84892959147
-
The immune system and response to HER2-targeted treatment in breast cancer
-
Bianchini G, Gianni L.The immune system and response to HER2-targeted treatment in breast cancer. Lancet Oncol 2014;15:e58–e68.
-
(2014)
Lancet Oncol
, vol.15
-
-
Bianchini, G.1
Gianni, L.2
-
52
-
-
84982889739
-
Tumorinfiltrating lymphocytes and associations with pathological complete response and event-free survival in HER2-positive early-stage breast cancer treated with lapatinib and trastuzumab: A secondary analysis of the NeoALTTO Trial
-
Salgado R, Denkert C, Campbell C et al. Tumorinfiltrating lymphocytes and associations with pathological complete response and event-free survival in HER2-positive early-stage breast cancer treated with lapatinib and trastuzumab: A secondary analysis of the NeoALTTO Trial. JAMA Oncol 2015;1:448–454.
-
(2015)
JAMA Oncol
, vol.1
, pp. 448-454
-
-
Salgado, R.1
Denkert, C.2
Campbell, C.3
|