Regional Gray Matter Volumes Are Related to Concern about Falling in Older People: A Voxel-Based Morphometric Study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 1, 2015, Pages 138-144

  Tuerk, Carola ^a   Zhang, Haobo ^b   Sachdev, Perminder ^b   Lord, Stephen R ^a   Brodaty, Henry ^b,c   Wen, Wei ^b   Delbaere, Kim ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

Accidental falls; Aged; Brain atrophy; Fear of falling; Magnetic resonance imaging; Neurodegeneration; Personality; Psychological distress

Indexed keywords

AGED; CEREBELLUM; EMOTION; EXECUTIVE FUNCTION; FALLING; FEMALE; FUNCTIONAL NEUROIMAGING; GRAY MATTER; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; PREVENTION AND CONTROL; PROCEDURES; RISK FACTOR; STATISTICS; VERY ELDERLY; VISION;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; CEREBELLUM; EMOTIONS; EXECUTIVE FUNCTION; FEMALE; FUNCTIONAL NEUROIMAGING; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OCCIPITAL LOBE; ORGAN SIZE; RISK FACTORS; STATISTICS AS TOPIC; VISUAL PERCEPTION;

EID: 84960500602     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glu242     Document Type: Article

References (31)

1. Lord SR, Ward JA. Age-associated differences in sensori-motor function and balance in community dwelling women. Age Ageing. 1994;23:452-460.
2. Delbaere K, Sturnieks DL, Crombez G, Lord SR. Concern about falls elicits changes in gait parameters in conditions of postural threat in older people. J Gerontol A Biol Sci Med Sci. 2009;64:237-242. doi:10.1093/gerona/gln014
3. Maki BE, Holliday PJ, Topper AK. Fear of falling and postural performance in the elderly. J Gerontol. 1991;46:M123-M131.
4. Delbaere K, Close JCT, Brodaty H, Sachdev P, Lord SR. Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. BMJ. 2010;341:c4165. doi:10.1136/bmj
5. Delbaere K, Crombez G, Vanderstraeten G, Willems T, Cambier D. Fearrelated avoidance of activities, falls and physical frailty. A prospective community-based cohort study. Age Ageing. 2004;33:368-373. doi:10.1093/ageing/afh106
6. Mann R, Birks Y, Hall J, Torgerson D, Watt I. Exploring the relationship between fear of falling and neuroticism: a cross-sectional study in community-dwelling women over 70. Age Ageing. 2006;35:143-147. doi:10.1093/ageing/afj013
7. Bach-y-Rita P, Kercel SW. Sensory substitution and the human-machine interface. Trends Cogn Sci. 2003;7:541-546. doi:10.1016/j. tics.2003.10.013
8. Webb SJ, Monk CS, Nelson CA. Mechanisms of postnatal neurobiological development: implications for human development. Dev Neuropsychol. 2001;19:147-171.
9. Rosano C, Brach J, Studenski S, Longstreth WT Jr, Newman AB. Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults. Neuroepidemiology. 2007;29:193-200. doi:10.1159/000111582
10. Rosano C, Aizenstein H, Brach J, Longenberger A, Studenski S, Newman AB. Gait measures indicate underlying focal gray matter atrophy in the brain of older adults. J Gerontol A Biol Sci Med Sci. 2008;63:1380-1388.
11. Schulkin J, McEwen BS, Gold PW. Allostasis, amygdala, and anticipatory angst. Neurosci Biobehav Rev. 1994;18:385-396. doi:10.1016/0149-7634(94)90051-5
12. Schienle A, Ebner F, Scher A. Localized gray matter volume abnormalities in generalized anxiety disorder. Eur Arch Psychiatry Clin Neurosci. 2011;261:303-307. doi:10.1007/s00406-010-0147-5
13. Davis JC, Nagamatsu LS, Hsu CL, Beattie BL, Liu-Ambrose T. Self-efficacy is independently associated with brain volume in older women. Age Ageing. 2012;41:495-501. doi:10.1093/ageing/afs029
14. McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006;8:367-381.
15. Sachdev PS, Brodaty H, Reppermund S, et al. The Sydney Memory and Ageing Study (MAS): methodology and baseline medical and neuropsychiatric characteristics of an elderly epidemiological nondemented cohort of Australians aged 70-90 years. Int Psychogeriatr. 2010;22:1248-1264. doi:10.1017/S1041610210001067
16. Yardley L, Beyer N, Hauer K, Kempen G, Piot-Ziegler C, Todd C. Development and initial validation of the Falls Efficacy Scale-International (FES-I). Age Ageing. 2005;34:614-619. doi:10.1093/ageing/afi196
17. Goldberg D, Bridges K, Duncan-Jones P, Grayson D. Detecting anxiety and depression in general medical settings. BMJ. 1988;297:897-899.
18. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
19. Costa Jr PT, McCrae RR. Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Odessa, FL: PAR; 1992.
20. D'Agostino RB Sr, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation. 2008;117:743-753. doi:10.1161/CIRCULATIONAHA.107.699579
21. Home page for the World Health Organization Disability Assessment Schedule II (WHODAS II). 2001. http://wwwwhoint/icidh/whodas/indexhtml. Accessed July 28, 2009.
22. Lord SR, Menz HB, Tiedemann A. A physiological profile approach to falls risk assessment and prevention. Phys Ther. 2003;83:237-252.
23. Wen W, Sachdev PS, Li JJ, Chen X, Anstey KJ. White matter hyperintensities in the forties: their prevalence and topography in an epidemiological sample aged 44-48. Hum Brain Mapp. 2009;30:1155-1167. doi:10.1002/hbm.20586
24. Mechelli A, Price CJ, Friston KJ, Ashburner J. Voxel-based morphometry of the human brain: methods and applications. Curr Med Imaging Rev. 2005;1:105-113.
25. Gaymard B, Rivaud S, Pierrot-Deseilligny C. Role of the left and right supplementary motor areas in memory-guided saccade sequences. Ann Neurol. 1993;34:404-406.
26. Molinari M, Petrosini L, Misciagna S, Leggio MG. Visuospatial abilities in cerebellar disorders. J Neurol Neurosurg Psychiatry. 2004;75:235-240.
27. O'Loughlin JL, Robitaille Y, Boivin JF, Suissa S. Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly. Am J Epidemiol. 1993;137:342-354.
28. Kravitz DJ, Saleem KS, Baker CI, Mishkin M. A new neural framework for visuospatial processing. Nat Rev Neurosci. 2011;12:217-230. doi:10.1038/nrn3008
29. Hall NJ, Colby CL. Remapping for visual stability. Philos Trans R Soc B. 2011;366:528-539. doi:10.1098/rstb.2010.0248
30. Krolak-Salmon P, Haff MA, Vighetto A, Bertrand O, Mauguie F. Early amygdala reaction to fear spreading in occipital, temporal, and frontal cortex: a depth electrode ERP study in human. Neuron. 2004;42:665-676. doi:10.1016/S0896-6273(04)00264-8
31. Lucan JN, Foxe JJ, Gomez-Ramirez M, Sathian K, Molholm S. Tactile shape discrimination recruits human lateral occipital complex during early perceptual processing. Hum Brain Mapp. 2010;31:1813-1821. doi:10.1002/hbm.20983