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Volumn 33, Issue 12, 2015, Pages 517-527

Overview and management of toxicities associated with systemic therapies for advanced renal cell carcinoma

Author keywords

Adverse event; Immune checkpoint inhibitors; Renal cell carcinoma; Toxicity; Vascular endothelial growth factor

Indexed keywords

ANTIHYPERTENSIVE AGENT; ATEZOLIZUMAB; AXITINIB; BEVACIZUMAB; EVEROLIMUS; IPILIMUMAB; LEVOTHYROXINE; NIVOLUMAB; PAZOPANIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VASCULOTROPIN A;

EID: 84960434934     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2015.07.020     Document Type: Review
Times cited : (14)

References (68)
  • 1
    • 77949280134 scopus 로고    scopus 로고
    • Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma
    • Leibovich B.C., Lohse C.M., Crispen P.L., Boorjian S.A., Thompson R.H., Blute M.L., et al. Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. J Urol 2010, 183:1309-1315.
    • (2010) J Urol , vol.183 , pp. 1309-1315
    • Leibovich, B.C.1    Lohse, C.M.2    Crispen, P.L.3    Boorjian, S.A.4    Thompson, R.H.5    Blute, M.L.6
  • 4
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: from rational design to clinical efficacy
    • Chow L.Q., Eckhardt S.G. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007, 25:884-896.
    • (2007) J Clin Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 5
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Oudard S., et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009, 27:3584-3590.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Oudard, S.6
  • 7
    • 67650173972 scopus 로고    scopus 로고
    • Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy
    • Torino F., Corsello S.M., Longo R., Barnabei A., Gasparini G. Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nat Rev Clin Oncol 2009, 6:219-228.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 219-228
    • Torino, F.1    Corsello, S.M.2    Longo, R.3    Barnabei, A.4    Gasparini, G.5
  • 8
    • 67651201656 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial
    • Gore M.E., Szczylik C., Porta C., Bracarda S., Bjarnason G.A., Oudard S., et al. Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 2009, 10:757-763.
    • (2009) Lancet Oncol , vol.10 , pp. 757-763
    • Gore, M.E.1    Szczylik, C.2    Porta, C.3    Bracarda, S.4    Bjarnason, G.A.5    Oudard, S.6
  • 9
    • 84893831040 scopus 로고    scopus 로고
    • Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules
    • Atkinson B.J., Kalra S., Wang X., Bathala T., Corn P., Tannir N.M., et al. Clinical outcomes for patients with metastatic renal cell carcinoma treated with alternative sunitinib schedules. J Urol 2014, 191:611-618.
    • (2014) J Urol , vol.191 , pp. 611-618
    • Atkinson, B.J.1    Kalra, S.2    Wang, X.3    Bathala, T.4    Corn, P.5    Tannir, N.M.6
  • 10
    • 79956269985 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma: recommendations for management of noncardiovascular toxicities
    • Kollmannsberger C., Bjarnason G., Burnett P., Creel P., Davis M., Dawson N., et al. Sunitinib in metastatic renal cell carcinoma: recommendations for management of noncardiovascular toxicities. Oncologist 2011, 16:543-553.
    • (2011) Oncologist , vol.16 , pp. 543-553
    • Kollmannsberger, C.1    Bjarnason, G.2    Burnett, P.3    Creel, P.4    Davis, M.5    Dawson, N.6
  • 11
    • 84897097674 scopus 로고    scopus 로고
    • A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma
    • Najjar Y.G., Mittal K., Elson P., Wood L., Garcia J.A., Dreicer R., et al. A 2 weeks on and 1 week off schedule of sunitinib is associated with decreased toxicity in metastatic renal cell carcinoma. Eur J Cancer 2014, 50:1084-1089.
    • (2014) Eur J Cancer , vol.50 , pp. 1084-1089
    • Najjar, Y.G.1    Mittal, K.2    Elson, P.3    Wood, L.4    Garcia, J.A.5    Dreicer, R.6
  • 12
    • 84960417220 scopus 로고    scopus 로고
    • [package insert]. New York (NY): Pfizer Inc.
    • Sutent® [package insert]. New York (NY): Pfizer Inc.; 2011.
    • (2011)
  • 13
    • 84938060465 scopus 로고    scopus 로고
    • Hypertension and angiotensin system inhibitors: impact on outcome in sunitinib-treated patients for metastatic renal cell carcinoma
    • Izzedine H., Derosa L., Le Teuff G., Albiges L., Escudier B. Hypertension and angiotensin system inhibitors: impact on outcome in sunitinib-treated patients for metastatic renal cell carcinoma. Ann Oncol 2015, 26:1128-1133.
    • (2015) Ann Oncol , vol.26 , pp. 1128-1133
    • Izzedine, H.1    Derosa, L.2    Le Teuff, G.3    Albiges, L.4    Escudier, B.5
  • 14
    • 69849085146 scopus 로고    scopus 로고
    • Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis
    • Di Lorenzo G., Autorino R., Bruni G., Carteni G., Ricevuto E., Tudini M., et al. Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis. Ann Oncol 2009, 20:1535-1542.
    • (2009) Ann Oncol , vol.20 , pp. 1535-1542
    • Di Lorenzo, G.1    Autorino, R.2    Bruni, G.3    Carteni, G.4    Ricevuto, E.5    Tudini, M.6
  • 15
    • 84904070535 scopus 로고    scopus 로고
    • Cardiovascular events among 1090 cancer patients treated with sunitinib, interferon, or placebo: a comprehensive adjudicated database analysis demonstrating clinically meaningful reversibility of cardiac events
    • Ewer M.S., Suter T.M., Lenihan D.J., Niculescu L., Breazna A., Demetri G.D., et al. Cardiovascular events among 1090 cancer patients treated with sunitinib, interferon, or placebo: a comprehensive adjudicated database analysis demonstrating clinically meaningful reversibility of cardiac events. Eur J Cancer 2014, 50:2162-2170.
    • (2014) Eur J Cancer , vol.50 , pp. 2162-2170
    • Ewer, M.S.1    Suter, T.M.2    Lenihan, D.J.3    Niculescu, L.4    Breazna, A.5    Demetri, G.D.6
  • 16
    • 33846978108 scopus 로고    scopus 로고
    • Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib
    • Rini B.I., Tamaskar I., Shaheen P., Salas R., Garcia J., Wood L., et al. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007, 99:81-83.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 81-83
    • Rini, B.I.1    Tamaskar, I.2    Shaheen, P.3    Salas, R.4    Garcia, J.5    Wood, L.6
  • 17
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies
    • Hutson T.E., Figlin R.A., Kuhn J.G., Motzer R.J. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 2008, 13:1084-1096.
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3    Motzer, R.J.4
  • 18
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
    • Sternberg C.N., Davis I.D., Mardiak J., Szczylik C., Lee E., Wagstaff J., et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010, 28:1061-1068.
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3    Szczylik, C.4    Lee, E.5    Wagstaff, J.6
  • 20
    • 84960383501 scopus 로고    scopus 로고
    • [package insert]. Research Triangle Park (NC): GlaxoSmithKline
    • Vortrient® [package insert]. Research Triangle Park (NC): GlaxoSmithKline; 2009.
    • (2009)
  • 21
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., Wilkie D., McNabola A., Rong H., et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004, 64:7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 23
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Staehler M., et al. Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial. J Clin Oncol 2009, 27:3312-3318.
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3    Szczylik, C.4    Oudard, S.5    Staehler, M.6
  • 24
    • 77149126422 scopus 로고    scopus 로고
    • Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America
    • Stadler W.M., Figlin R.A., McDermott D.F., Dutcher J.P., Knox J.J., Miller W.H., et al. Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America. Cancer 2010, 116:1272-1280.
    • (2010) Cancer , vol.116 , pp. 1272-1280
    • Stadler, W.M.1    Figlin, R.A.2    McDermott, D.F.3    Dutcher, J.P.4    Knox, J.J.5    Miller, W.H.6
  • 25
    • 79955804850 scopus 로고    scopus 로고
    • Treatment-associated adverse event management in the advanced renal cell carcinoma patient treated with targeted therapies
    • Ravaud A. Treatment-associated adverse event management in the advanced renal cell carcinoma patient treated with targeted therapies. Oncologist 2011, 16(Suppl. 2):32-44.
    • (2011) Oncologist , vol.16 , pp. 32-44
    • Ravaud, A.1
  • 27
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial
    • Rini B.I., Escudier B., Tomczak P., Kaprin A., Szczylik C., Hutson T.E., et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet 2011, 378:1931-1939.
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3    Kaprin, A.4    Szczylik, C.5    Hutson, T.E.6
  • 28
    • 84888132613 scopus 로고    scopus 로고
    • Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial
    • Hutson T.E., Lesovoy V., Al-Shukri S., Stus V.P., Lipatov O.N., Bair A.H., et al. Axitinib versus sorafenib as first-line therapy in patients with metastatic renal-cell carcinoma: a randomised open-label phase 3 trial. Lancet Oncol 2013, 14:1287-1294.
    • (2013) Lancet Oncol , vol.14 , pp. 1287-1294
    • Hutson, T.E.1    Lesovoy, V.2    Al-Shukri, S.3    Stus, V.P.4    Lipatov, O.N.5    Bair, A.H.6
  • 29
    • 84960420030 scopus 로고    scopus 로고
    • [package insert]. New York (NY): Pfizer;
    • Inlyta® [package insert]. New York (NY): Pfizer; 2012.
    • (2012)
  • 30
    • 84860181409 scopus 로고    scopus 로고
    • [Accessed 01.04.15].
    • National Comprehensive Cancer Network (2011) Cancer-related fatigue. ; [Accessed 01.04.15]. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp.
    • (2011) Cancer-related fatigue
  • 32
    • 84867844763 scopus 로고    scopus 로고
    • Antiangiogenic therapy for advanced renal cell carcinoma: management of treatment-related toxicities
    • Cohen R.B., Oudard S. Antiangiogenic therapy for advanced renal cell carcinoma: management of treatment-related toxicities. Invest New Drugs 2012, 30:2066-2079.
    • (2012) Invest New Drugs , vol.30 , pp. 2066-2079
    • Cohen, R.B.1    Oudard, S.2
  • 33
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results
    • Rugo H.S., Herbst R.S., Liu G., Park J.W., Kies M.S., Steinfeldt H.M., et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005, 23:5474-5483.
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3    Park, J.W.4    Kies, M.S.5    Steinfeldt, H.M.6
  • 34
    • 77952300540 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival
    • Escudier B., Bellmunt J., Negrier S., Bajetta E., Melichar B., Bracarda S., et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): final analysis of overall survival. J Clin Oncol 2010, 28:2144-2150.
    • (2010) J Clin Oncol , vol.28 , pp. 2144-2150
    • Escudier, B.1    Bellmunt, J.2    Negrier, S.3    Bajetta, E.4    Melichar, B.5    Bracarda, S.6
  • 35
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B., Pluzanska A., Koralewski P., Ravaud A., Bracarda S., Szczylik C., et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007, 370:2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3    Ravaud, A.4    Bracarda, S.5    Szczylik, C.6
  • 36
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini B.I., Halabi S., Rosenberg J.E., Stadler W.M., Vaena D.A., Ou S.S., et al. Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008, 26:5422-5428.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Ou, S.S.6
  • 37
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206
    • Rini B.I., Halabi S., Rosenberg J.E., Stadler W.M., Vaena D.A., Archer L., et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010, 28:2137-2143.
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3    Stadler, W.M.4    Vaena, D.A.5    Archer, L.6
  • 38
    • 84960343244 scopus 로고    scopus 로고
    • [package insert]. South San Francisco (CA): Genetech Inc.
    • Avastin® [package insert]. South San Francisco (CA): Genetech Inc.; 2009.
    • (2009)
  • 39
    • 85031877949 scopus 로고    scopus 로고
    • [package insert]. Philadelphia: Wyeth Pharmaceuticals, Inc.
    • Torisel® [package insert]. Philadelphia: Wyeth Pharmaceuticals, Inc.; 2007.
    • (2007)
  • 40
    • 85031876369 scopus 로고    scopus 로고
    • [package insert]. East Hanover (NJ): Novartis Pharmaceuticals Corp
    • Afinitor® [package insert]. East Hanover (NJ): Novartis Pharmaceuticals Corp.; 2009.
    • (2009)
  • 41
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • Bjornsti M.A., Houghton P.J. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004, 4:335-348.
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 42
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G., Carducci M., Tomczak P., Dutcher J., Figlin R., Kapoor A., et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007, 356:2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3    Dutcher, J.4    Figlin, R.5    Kapoor, A.6
  • 43
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
    • Motzer R.J., Escudier B., Oudard S., Hutson T.E., Porta C., Bracarda S., et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 44
    • 74549192779 scopus 로고    scopus 로고
    • Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients
    • Sonis S., Treister N., Chawla S., Demetri G., Haluska F. Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients. Cancer 2010, 116:210-215.
    • (2010) Cancer , vol.116 , pp. 210-215
    • Sonis, S.1    Treister, N.2    Chawla, S.3    Demetri, G.4    Haluska, F.5
  • 45
    • 84903733990 scopus 로고    scopus 로고
    • Strategies for the management of adverse events associated with mTOR inhibitors
    • Kaplan B., Qazi Y., Wellen J.R. Strategies for the management of adverse events associated with mTOR inhibitors. Transplant Rev (Orlando) 2014, 28:126-133.
    • (2014) Transplant Rev (Orlando) , vol.28 , pp. 126-133
    • Kaplan, B.1    Qazi, Y.2    Wellen, J.R.3
  • 46
    • 77949517428 scopus 로고    scopus 로고
    • Management of mTOR inhibitor side effects
    • Creel P.A. Management of mTOR inhibitor side effects. Clin J Oncol Nurs 2009, 13(Suppl.):19-23.
    • (2009) Clin J Oncol Nurs , vol.13 , pp. 19-23
    • Creel, P.A.1
  • 48
    • 33748053644 scopus 로고    scopus 로고
    • Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses
    • Stokman M.A., Spijkervet F.K., Boezen H.M., Schouten J.P., Roodenburg J.L., de Vries E.G. Preventive intervention possibilities in radiotherapy- and chemotherapy-induced oral mucositis: results of meta-analyses. J Dent Res 2006, 85:690-700.
    • (2006) J Dent Res , vol.85 , pp. 690-700
    • Stokman, M.A.1    Spijkervet, F.K.2    Boezen, H.M.3    Schouten, J.P.4    Roodenburg, J.L.5    de Vries, E.G.6
  • 49
    • 84923769898 scopus 로고    scopus 로고
    • Evidence-based interventions for cancer treatment-related mucositis: putting evidence into practice
    • Eilers J., Harris D., Henry K., Johnson L.A. Evidence-based interventions for cancer treatment-related mucositis: putting evidence into practice. Clin J Oncol Nurs 2014, 18(Suppl.):80-96.
    • (2014) Clin J Oncol Nurs , vol.18 , pp. 80-96
    • Eilers, J.1    Harris, D.2    Henry, K.3    Johnson, L.A.4
  • 50
    • 79957566962 scopus 로고    scopus 로고
    • Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma
    • Porta C., Osanto S., Ravaud A., Climent M.A., Vaishampayan U., White D.A., et al. Management of adverse events associated with the use of everolimus in patients with advanced renal cell carcinoma. Eur J Cancer 2011, 47:1287-1298.
    • (2011) Eur J Cancer , vol.47 , pp. 1287-1298
    • Porta, C.1    Osanto, S.2    Ravaud, A.3    Climent, M.A.4    Vaishampayan, U.5    White, D.A.6
  • 51
    • 33845385653 scopus 로고    scopus 로고
    • The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review
    • Potting C.M., Uitterhoeve R., Op Reimer W.S., Van Achterberg T. The effectiveness of commonly used mouthwashes for the prevention of chemotherapy-induced oral mucositis: a systematic review. Eur J Cancer Care (Engl) 2006, 15:431-439.
    • (2006) Eur J Cancer Care (Engl) , vol.15 , pp. 431-439
    • Potting, C.M.1    Uitterhoeve, R.2    Op Reimer, W.S.3    Van Achterberg, T.4
  • 53
    • 70349941402 scopus 로고    scopus 로고
    • Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity
    • Feagans J., Victor D., Moehlen M., Florman S.S., Regenstein F., Balart L.A., et al. Interstitial pneumonitis in the transplant patient: consider sirolimus-associated pulmonary toxicity. J La State Med Soc 2009, 161:166,168-172.
    • (2009) J La State Med Soc , vol.161 , pp. 166-172
    • Feagans, J.1    Victor, D.2    Moehlen, M.3    Florman, S.S.4    Regenstein, F.5    Balart, L.A.6
  • 54
    • 77951282223 scopus 로고    scopus 로고
    • Emergent toxicities associated with the use of mTOR inhibitors in patients with advanced renal carcinoma
    • Rodriguez-Pascual J., Cheng E., Maroto P., Duran I. Emergent toxicities associated with the use of mTOR inhibitors in patients with advanced renal carcinoma. Anticancer Drugs 2010, 21:478-486.
    • (2010) Anticancer Drugs , vol.21 , pp. 478-486
    • Rodriguez-Pascual, J.1    Cheng, E.2    Maroto, P.3    Duran, I.4
  • 56
    • 84905083767 scopus 로고    scopus 로고
    • PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence
    • Tykodi S.S. PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence. Onco Targets Ther 2014, 7:1349-1359.
    • (2014) Onco Targets Ther , vol.7 , pp. 1349-1359
    • Tykodi, S.S.1
  • 57
    • 84945293157 scopus 로고    scopus 로고
    • Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy
    • [Epub ahead of print]
    • Lu J., Lee-Gabel L., Nadeau M.C., Ferencz T.M., Soefje S.A. Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy. J Oncol Pharm Pract 2015, [Epub ahead of print].
    • (2015) J Oncol Pharm Pract
    • Lu, J.1    Lee-Gabel, L.2    Nadeau, M.C.3    Ferencz, T.M.4    Soefje, S.A.5
  • 58
    • 84929361060 scopus 로고    scopus 로고
    • Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab
    • McDermott D.F., Drake C.G., Sznol M., Choueiri T.K., Powderly J.D., Smith D.C., et al. Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab. J Clin Oncol 2015, 33:2013-2020.
    • (2015) J Clin Oncol , vol.33 , pp. 2013-2020
    • McDermott, D.F.1    Drake, C.G.2    Sznol, M.3    Choueiri, T.K.4    Powderly, J.D.5    Smith, D.C.6
  • 59
  • 62
    • 84915804784 scopus 로고    scopus 로고
    • Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist
    • Weber J.S. Practical management of immune-related adverse events from immune checkpoint protein antibodies for the oncologist. Am Soc Clin Oncol Educ Book 2012, 174-177.
    • (2012) Am Soc Clin Oncol Educ Book , pp. 174-177
    • Weber, J.S.1
  • 63
    • 61349114199 scopus 로고    scopus 로고
    • Ipilimumab: controversies in its development, utility and autoimmune adverse events
    • Weber J. Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 2009, 58:823-830.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 823-830
    • Weber, J.1
  • 64
    • 79952745218 scopus 로고    scopus 로고
    • Resolution of severe ipilimumab-induced hepatitis after antithymocyte globulin therapy
    • Chmiel K.D., Suan D., Liddle C., Nankivell B., Ibrahim R., Bautista C., et al. Resolution of severe ipilimumab-induced hepatitis after antithymocyte globulin therapy. J Clin Oncol 2011, 29:e237-e240.
    • (2011) J Clin Oncol , vol.29 , pp. e237-e240
    • Chmiel, K.D.1    Suan, D.2    Liddle, C.3    Nankivell, B.4    Ibrahim, R.5    Bautista, C.6
  • 65
    • 27444440093 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
    • Blansfield J.A., Beck K.E., Tran K., Yang J.C., Hughes M.S., Kammula U.S., et al. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. J Immunother 2005, 28:593-598.
    • (2005) J Immunother , vol.28 , pp. 593-598
    • Blansfield, J.A.1    Beck, K.E.2    Tran, K.3    Yang, J.C.4    Hughes, M.S.5    Kammula, U.S.6
  • 66
    • 77949274549 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes
    • Dillard T., Yedinak C.G., Alumkal J., Fleseriu M. Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 2010, 13:29-38.
    • (2010) Pituitary , vol.13 , pp. 29-38
    • Dillard, T.1    Yedinak, C.G.2    Alumkal, J.3    Fleseriu, M.4
  • 68
    • 85031877147 scopus 로고    scopus 로고
    • [package insert]. Princeton (NJ): Bristol-Myers Squibb Company
    • Opdivo® [package insert]. Princeton (NJ): Bristol-Myers Squibb Company; 2014.
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.