Low-dose iron supplementation in infancy modestly increases infant iron status at 9 mo without decreasing growth or increasing illness in a randomized clinical trial in rural China

Journal of Nutrition

Volumn 146, Issue 3, 2016, Pages 612-621

  Lozoff, Betsy ^a   Jiang, Yaping ^b   Li, Xing ^b   Zhou, Min ^b   Richards, Blair ^a   Xu, Guobin ^b   Clark, Katy M ^a   Liang, Furong ^b   Kaciroti, Niko ^a   Zhao, Gengli ^b   Santos, Denise C C ^c   Zhang, Zhixiang ^b   Tardif, Twila ^a   Li, Ming ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PEKING UNIVERSITY FIRST HOSPITAL   (China)

^c METHODIST UNIVERSITY OF PIRACICABA   (Brazil)

Author keywords

Growth; Infancy; Iron deficiency; Iron deficiency anemia; Iron supplementation; Pregnancy; Randomized clinical trial

Indexed keywords

C REACTIVE PROTEIN; FERROUS SULFATE; FOLIC ACID; HEME; HEMOGLOBIN; IRON; IRON PROTEIN SUCCINYLATE; PLACEBO; FERRITIN; IRON INTAKE;

ARTICLE; BODY HEIGHT; BODY WEIGHT; CHILD GROWTH; CHILD HOSPITALIZATION; CHINA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; FEMALE; GASTROINTESTINAL SYMPTOM; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANT; INFANT DISEASE; INTENTION TO TREAT ANALYSIS; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL; RURAL AREA; SINGLE DRUG DOSE; UMBILICAL CORD BLOOD; ADMINISTRATION AND DOSAGE; ANEMIA, IRON-DEFICIENCY; BLOOD; DEFICIENCY; DIETARY SUPPLEMENT; INFANT NUTRITION; IRON INTAKE; MATERNAL NUTRITION; METABOLISM; NUTRITIONAL STATUS; PREGNANCY; PREVALENCE; RURAL POPULATION; STATISTICAL MODEL;

ANEMIA, IRON-DEFICIENCY; BODY WEIGHT; CHINA; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; IRON; IRON, DIETARY; LOGISTIC MODELS; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; NUTRITIONAL STATUS; PREGNANCY; PREVALENCE; RURAL POPULATION;

EID: 84960412533     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.223917     Document Type: Article

References (41)

1. Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Pena-Rosas JP, Bhutta ZA, Ezzati M. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health 2013;1:e16-25.
2. LozoffB. Iron deficiency and child development. Food Nutr Bull 2007;28:S560-71.
3. GeorgieffMK. Long-term brain and behavioral consequences of early iron deficiency. Nutr Rev 2011;69:S43-8.
4. Zhao G, Xu G, Zhou M, Jiang Y, Richards B, Clark KM, Kaciroti N, GeorgieffMK, Zhang Z, Tardif T, et al. Prenatal iron supplementation reduces maternal anemia, iron deficiency, and iron deficiency anemia in a randomized clinical trial in rural China, but iron deficiency remains widespread in mothers and neonates. J Nutr 2015;145:1916-23.
5. Christian P, Morgan ME, Murray-Kolb L, LeClerq SC, Khatry SK, Schaefer B, Cole PM, Katz J, Tielsch JM. Preschool iron-folic acid and zinc supplementation in children exposed to iron-folic acid in utero confers no added cognitive benefit in early school-age. J Nutr 2011;141:2042-8.
6. Haider BA, Olofin I, Wang M, Spiegelman D, Ezzati M, Fawzi WW. Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 2013;346:f3443.
7. Imdad A, Bhutta ZA. Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes. Paediatr Perinat Epidemiol 2012;26(Suppl 1):168-77.
8. Peña-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 2012;12:CD004736.
9. Pasricha SR, Hayes E, Kalumba K, Biggs BA. Effect of daily iron supplementation on health in children aged 4-23 months: a systematic review and meta-analysis of randomised controlled trials. Lancet Glob Health 2013;1:e77-86.
10. Gera T, Sachdev HP, Nestel P, Sachdev SS. Effect of iron supplementation on haemoglobin response in children: systematic review of randomised controlled trials. J Pediatr Gastroenterol Nutr 2007;44: 468-86.
11. Vucic V, Berti C, Volhardt C, Fekete K, Cetin I, Koletzko B, Gurinovic M, van't Veer P. Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with metaanalysis. Nutr Rev 2013;71:386-401.
12. McDonagh MS, Blazina I, Dana T, Cantor A, Bougatsos C. Screening and routine supplementation for iron deficiency anemia: a systematic review. Pediatrics 2015;135:723-33.
13. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutr 2006;9:904-20.
14. De-Regil LM, Jefferds MED, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database Syst Rev 2011;7: CD009085.
15. Olney DK, Pollitt E, Kariger PK, Khalfan SS, Ali NS, Tielsch JM, Sazawal S, Black R, Allen LH, Stoltzfus RJ. Combined iron and folic acid supplementation with or without zinc reduces time to walking unassisted among Zanzibari infants 5-to 11-mo old. J Nutr 2006;136: 2427-34.
16. Black MM, Baqui AH, Zaman K, Ake PL, El Arifeen S, Le K, McNary SW, Parveen M, Hamadani JD, Black RE. Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. Am J Clin Nutr 2004;80:903-10.
17. Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr 2006;84: 1261-76.
18. Domellöf M. Benefits and harms of iron supplementation in irondeficient and iron-sufficient children. Nestle Nutr Workshop Ser Pediatr Program 2010;65:153-62.
19. Siddappa AM, GeorgieffMK, Wewerka S, Worwa C, Nelson CA, Deregnier RA. Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers. Pediatr Res 2004;55:1034-41.
20. LozoffB, Clark KM, Jing Y, Armony-Sivan R, Angelilli ML, Jacobson SW. Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior. J Pediatr 2008;152:696-702.
21. CDC. Healthy People 2000 national health promotion and disease prevention objectives final review. Hyattsville (MD): Department of Health and Human Services; 2001.
22. Soldin OP, Miller M, Soldin SJ. Pediatric reference ranges for zinc protoporphyrin. Clin Biochem 2003;36:21-5.
23. Saarinen UM, Siimes MA. Serum ferritin in assessment of iron nutrition in healthy infants. Acta Paediatr Scand 1978;67:745-51.
24. Cook JD, Flowers CH, Skikne BS. The quantitative assessment of body iron. Blood 2003;101:3359-64.
25. Flowers CH, Skikne BS, Covell AM, Cook JD. The clinical measurement of serum transferrin receptor. J Lab Clin Med 1989;114:368-77.
26. Pfeiffer CM, Cook JD, Mei Z, Cogswell ME, Looker AC, Lacher DA. Evaluation of an automated soluble transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays. Clin Chim Acta 2007;382:112-6.
27. Thorpe SJ, Heath A, Sharp G, Cook J, Ellis R, Worwood M. A WHO reference reagent for the Serum Transferrin Receptor (sTfR): international collaborative study to evaluate a recombinant soluble transferrin receptor preparation. Clin Chem Lab Med 2010;48:815-20.
28. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr 2002;140:165-70.
29. Amin SB, Orlando M, Eddins A, MacDonald M, Monczynski C, Wang H. In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response. J Pediatr 2010;156: 377-81.
30. Armony-Sivan R, Eidelman AI, Lanir A, Sredni D, Yehuda S. Iron status and neurobehavioral development of premature infants. J Perinatol 2004;24:757-62.
31. McLimore HM, Phillips AK, Blohowiak SE, Pham DQ, Coe CL, Fischer B, Kling PJ. Impact of multiple risk factors on newborn iron status. J Pediatr Hematol Oncol 2013;35:473-7.
32. Sanhe City People's Government. Sanhe City People's Government on the issuance of "Sanhe 2013 annual public housing security plan" [Internet]. Sanhe City, Hebei (China) 2013 [cited 2015 Jun 1]. Available from: http://www.he.xinhuanet.com/zfwq/sanhe/zhengwu/zhengwu/2013-10/21/c_117803056.htm.
33. WHO. Child growth standards: WHO Anthro (version 3.2.2, January 2011) and macros [Internet]. Geneva (Switzerland): WHO. 2011 [cited 2014 Aug 14]. Available from: http://www.who.int/childgrowth/software/en/.
34. LozoffB, Walter T, Kaciroti N. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr 2006;84:1412-21.
35. Domellöf M, Braegger C, Campoy C, Colomb V, Decsi T, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, et al. Iron requirements of infants and toddlers. JPGN 2014;58:119-29.
36. Institute of Medicine. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington (DC): National Academies Press; 2001.
37. Golub MS, Hogrefe CE, Malka R, Higgins JM. Developmental plasticity of red blood cell homeostasis. Am J Hematol 2014;89:459-66.
38. Hernell O, Lonnerdal B. Recommendations on iron questioned. Pediatrics 2011;127:e1099-101.
39. Domellöf M, Cohen RJ, Dewey KG, Hernell O, Rivera LL, Lonnerdal B. Iron supplementation of breast-fed Honduran and Swedish infants from 4 to 9 months of age. J Pediatr 2001;138:679-87.
40. Friel JK, Aziz K, Andrews WL, Harding SV, Courage ML, Adams R. A double-masked, randomized control trial of iron supplementation in early infancy in healthy full-term breast-fed infants. J Pediatr 2003;143: 582-6.
41. Ziegler EE, Nelson SE, Jeter JM. Iron supplementation of breastfed infants from an early age. Am J Clin Nutr 2009;89:525-32.