Intratracheal administration of small interfering RNA targeting fas reduces lung ischemia-reperfusion injury

Critical Care Medicine

Volumn 44, Issue 8, 2016, Pages e604-e613

  Del Sorbo, Lorenzo ^a   Costamagna, Andrea ^a   Muraca, Giuseppe ^a   Rotondo, Giuseppe ^a   Civiletti, Federica ^a   Vizio, Barbara ^b   Bosco, Ornella ^b   Martin Conte, Erica L ^a   Frati, Giacomo ^c   Delsedime, Luisa ^a   Lupia, Enrico ^b   Fanelli, Vito ^a   Ranieri, V Marco ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

acute lung injury; apoptosis; Fas; inflammation; ischemia and reperfusion; small interfering ribonucleic acid

Indexed keywords

CASPASE 3; FAS ANTIGEN; MESSENGER RNA; MYELOPEROXIDASE; SMALL INTERFERING RNA; CYTOKINE; FAS PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; BRONCHOALVEOLAR LAVAGE FLUID; COLD ISCHEMIA; CONTROLLED STUDY; CYTOKINE RELEASE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; HISTOLOGY; ISOLATED LUNG; LUNG EDEMA; LUNG HEMORRHAGE; LUNG INJURY; LUNG LAVAGE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN CLEAVAGE; REPERFUSION INJURY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; EDEMA; LUNG DISEASES; METABOLISM; RANDOMIZATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; EDEMA; GENE EXPRESSION; LUNG DISEASES; MICE; MICE, INBRED C57BL; PROSPECTIVE STUDIES; RANDOM ALLOCATION; REPERFUSION INJURY; RNA, SMALL INTERFERING;

EID: 84960374786     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001601     Document Type: Article

References (45)

1. Christie JD, Carby M, Bag R, et al; ISHLT Working Group on Primary Lung Graft Dysfunction: Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II. Definition A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2005; 24: 1454-1459
2. Arcasoy SM, Fisher A, Hachem RR, et al; ISHLT Working Group on Primary Lung Graft Dysfunction: Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part V. Predictors and outcomes. J Heart Lung Transplant 2005; 24: 1483-1488
3. de Perrot M, Liu M, Waddell TK, et al. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167: 490-511
4. Suzuki Y, Cantu E, Christie JD. Primary graft dysfunction. Semin Respir Crit Care Med 2013; 34: 305-319
5. de Perrot M, Bonser RS, Dark J, et al; ISHLT Working Group on Primary Lung Graft Dysfunction: Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part III: Donor-related risk factors and markers. J Heart Lung Transplant 2005; 24: 1460-1467
6. Christie JD, Sager JS, Kimmel SE, et al. Impact of primary graft failure on outcomes following lung transplantation. Chest 2005; 127: 161-165
7. Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med 2011; 17: 1391-1401
8. den Hengst WA, Gielis JF, Lin JY, et al. Lung ischemia-reperfusion injury: A molecular and clinical view on a complex pathophysiological process. Am J Physiol Heart Circ Physiol 2010; 299: H1283-H1299
9. Perl M, Lomas-Neira J, Chung CS, et al. Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-A unifying hypothesis? What we have learned from small interfering RNAs. Mol Med 2008; 14: 465-475
10. Ng CS, Wan S, Yim AP. Pulmonary ischaemia-reperfusion injury: Role of apoptosis. Eur Respir J 2005; 25: 356-363
11. Fischer S, Maclean AA, Liu M, et al. Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation. Am J Respir Crit Care Med 2000; 162: 1932-1939
12. Matute-Bello G, Lee JS, Liles WC, et al. Fas-mediated acute lung injury requires fas expression on nonmyeloid cells of the lung. J Immunol 2005; 175: 4069-4075
13. Perl M, Chung CS, Perl U, et al. Fas-induced pulmonary apoptosis and inflammation during indirect acute lung injury. Am J Respir Crit Care Med 2007; 176: 591-601
14. Zhang X, Shan P, Alam J, et al. Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogenactivated protein kinase pathway during ischemia-reperfusion lung injury. J Biol Chem 2003; 278: 22061-22070
15. Hamar P, Song E, Kökény G, et al. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A 2004; 101: 14883-14888
16. Matsuda N, Yamamoto S, Takano K, et al. Silencing of fas-Associated death domain protects mice from septic lung inflammation and apoptosis. Am J Respir Crit Care Med 2009; 179: 806-815
17. Perl M, Chung CS, Lomas-Neira J, et al. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 2005; 167: 1545-1559
18. Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell 2006; 126: 231-235
19. Jiang N, Zhang X, Zheng X, et al A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis. PLoS One 2012; 7: e44138
20. Zheng X, Lian D, Wong A, et al. Novel small interfering RNAcontaining solution protecting donor organs in heart transplantation. Circulation 2009; 120: 1099-1107
21. Fanelli V, Puntorieri V, Assenzio B, et al. Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema. Intensive Care Med 2010; 36: 1935-1945
22. Spöhr F, Cornelissen AJ, Busch C, et al. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 2005; 289: H823-H831
23. von Bethmann AN, Brasch F, Nüsing R, et al. Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med 1998; 157: 263-272
24. Zhao M, Fernandez LG, Doctor A, et al. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 2006; 291: L1018-L1026
25. Lee JW, Krasnodembskaya A, McKenna DH, et al. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med 2013; 187: 751-760
26. Okazaki M, Krupnick AS, Kornfeld CG, et al A mouse model of orthotopic vascularized aerated lung transplantation. Am J Transplant 2007; 7: 1672-1679
27. Martin EL, Souza DG, Fagundes CT, et al. Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment. Am J Respir Crit Care Med 2010; 182: 762-773
28. Eefting F, Rensing B, Wigman J, et al. Role of apoptosis in reperfusion injury. Cardiovasc Res 2004; 61: 414-426
29. Hotchkiss RS, Strasser A, McDunn JE, et al. Cell death. N Engl J Med 2009; 361: 1570-1583
30. Munshi L, Keshavjee S, Cypel M. Donor management and lung preservation for lung transplantation. Lancet Respir Med 2013; 1: 318-328
31. Hamann KJ, Dorscheid DR, Ko FD, et al. Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium. Am J Respir Cell Mol Biol 1998; 19: 537-542
32. Herrero R, Tanino M, Smith LS, et al the Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. Am J Physiol Lung Cell Mol Physiol 2013; 305: L377-L388
33. Albertine KH, Soulier MF, Wang Z, et al. Fas and fas ligand are upregulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol 2002; 161: 1783-1796
34. Bardales RH, Xie SS, Schaefer RF, et al. Apoptosis is a major pathway responsible for the resolution of type II pneumocytes in acute lung injury. Am J Pathol 1996; 149: 845-852
35. Hashimoto S, Kobayashi A, Kooguchi K, et al. Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome. Am J Respir Crit Care Med 2000; 161: 237-243
36. Herrero R, Kajikawa O, Matute-Bello G, et al the biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. J Clin Invest 2011; 121: 1174-1190
37. Matute-Bello G, Liles WC, Steinberg KP, et al. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS). J Immunol 1999; 163: 2217-2225
38. Matute-Bello G, Winn RK, Jonas M, et al. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: Implications for acute pulmonary inflammation. Am J Pathol 2001; 158: 153-161
39. Farnand AW, Eastman AJ, Herrero R, et al. Fas activation in alveolar epithelial cells induces KC (CXCL1) release by a MyD88-dependent mechanism. Am J Respir Cell Mol Biol 2011; 45: 650-658
40. Ponton A, Clément MV, Stamenkovic I the CD95 (APO-1/Fas) receptor activates NF-kappaB independently of its cytotoxic function. J Biol Chem 1996; 271: 8991-8995
41. Dykxhoorn DM, Palliser D, Lieberman J the silent treatment: siRNAs as small molecule drugs. Gene Ther 2006; 13: 541-552
42. Leung RK, Whittaker PA. RNA interference: From gene silencing to gene-specific therapeutics. Pharmacol Ther 2005; 107: 222-239
43. Sibley CR, Seow Y, Wood MJ. Novel RNA-based strategies for therapeutic gene silencing. Mol Ther 2010; 18: 466-476
44. Cypel M, Yeung JC, Liu M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011; 364: 1431-1440
45. Cypel M, Keshavjee S the clinical potential of ex vivo lung perfusion. Expert Rev Respir Med 2012; 6: 27-35