Thrombocytopenic syndromes in pregnancy

Obstetric Medicine

Volumn 9, Issue 1, 2016, Pages 15-20

  Yan, Matthew ^a   Malinowski, Ann K ^b   Shehata, Nadine ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

immune thrombocytopenia; pre eclampsia; pregnancy; Thrombocytopenia; thrombotic microangiopathy

Indexed keywords

AZATHIOPRINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DANAZOL; ECULIZUMAB; IMMUNOGLOBULIN G ANTIBODY; LACTATE DEHYDROGENASE; PHOSPHOLIPID ANTIBODY; RITUXIMAB; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ANTIPHOSPHOLIPID SYNDROME; DISSEMINATED INTRAVASCULAR CLOTTING; FEMALE; GESTATIONAL THROMBOCYTOPENIA; HELLP SYNDROME; HEMOLYTIC UREMIC SYNDROME; HUMAN; HYPERTENSION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MORTALITY; NEONATAL ALLOIMMUNE THROMBOCYTOPENIA; NEWBORN MORBIDITY; PARTIAL THROMBOPLASTIN TIME; PREECLAMPSIA; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; REVIEW; THIRD TRIMESTER PREGNANCY; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOTIC THROMBOCYTOPENIC PURPURA;

EID: 84960367005     PISSN: 1753495X     EISSN: 17534968     Source Type: Journal    
DOI: 10.1177/1753495X15601937     Document Type: Review

References (42)

1. E.VerdyV.BessousM.Dreyfus. Longitudinal analysis of platelet count and volume in normal pregnancy. Thromb Haemost1997; 77: 806–807.
2. D.ProvanR.StasiA.C.Newland. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood2010; 115: 168–186.
3. F.BoehlenP.HohlfeldP.Extermann. Platelet count at term pregnancy: a reappraisal of the threshold. Obstet Gynecol2000; 95: 29–33.
4. R.F.BurrowsJ.G.Kelton. Thrombocytopenia at delivery: a prospective survey of 6715 deliveries. Am J Obstet Gynecol1990; 162: 731–734.
5. R.F.BurrowsJ.G.Kelton. Fetal thrombocytopenia and its relation to maternal thrombocytopenia. N Engl J Med1993; 329: 1463–1466.
6. N.WinM.RowleyC.Pollard. Severe gestational (incidental) thrombocytopenia: to treat or not to treat. Hematology2005; 10: 69–72.
7. T.GernsheimerJ.H.JamesR.Stasi. How I treat thrombocytopenia in pregnancy. Blood2013; 121: 38–47.
8. C.Pierrot-Deseilligny DespujolM.MichelM.Khellaf. Antiphospholipid antibodies in adults with immune thrombocytopenic purpura. Br J Haematol2008; 142: 638–643.
9. S.MiyakisM.D.LockshinT.Atsumi. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost2006; 4: 295–306.
10. M.J.CuadradoF.MujicE.Muñoz. Thrombocytopenia in the antiphospholipid syndrome. Ann Rheum Dis1997; 56: 194–196.
11. R.CerveraR.SerranoG.J.Pons-Estel. for the Euro-Phospholipid Project Group (European Forum on Antiphospholipid Antibodies) Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients. Ann Rheum Dis2015; 74: 1011–1018.
12. V.PengoA.RuffattiC.Legnani. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood2011; 118: 4714–4718.
13. G.LippiM.Plebani. EDTA-dependent pseudothrombocytopenia: further insights and recommendations for prevention of a clinically threatening artifact. Clin Chem Lab Med2012; 50: 1281–1285.
14. D.B.CinesJ.B.BusselH.A.Liebman. The ITP syndrome: pathogenic and clinical diversity. Blood2009; 113: 6511–6521.
15. F.RodeghieroR.StasiT.Gernsheimer. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood2009; 113: 2386–2393.
16. K.E.WebertR.MittalC.Sigouin. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura. Blood2003; 102: 4306–4311.
17. D.VeneriM.FranchiniR.Raffaelli. Idiotpathic thrombocytopenic purpura in pregnancy: analysis of 43 consecutive cases followed at a single Italian institution. Ann Hematol2006; 85: 552–554.
18. V.LoustauO.DebouverieF.Canoui-Poitrine. Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women. Br J Haematol2014; 166: 929–935.
19. B.Myers. Diagnosis and management of maternal thrombocytopenia in pregnancy. Br J Haematol2012; 158: 3–15.
20. A.HviidD.Molgaard-Nielsen. Corticosteroid use during pregnancy and risk of orofacial clefts. CMAJ2011; 183: 796–804.
21. L.Park-WyllieP.MazzottaA.Pastuszak. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology2000; 62: 385–392.
22. J.GriffithsW.SIaA.M.Shapiro. Laparascopic splenectomy for the treatment of refractory immune thrombocytopenia in pregnancy. J Obstet Gynaecol Can2005; 27: 771–774.
23. E.F.ChakravartyE.R.MurrayA.Kelman. Pregnancy outcomes after maternal exposure to rituximab. Blood2011; 117: 1499–1506.
24. R.L.CookR.C.MillerV.L.Katz. Immune thrombocytopenic purpura in pregnancy: a reappraisal of management. Obstet Gynecol1991; 78: 578–583.
25. H.OzkanM.CetinkayaN.Köksal. Neonatal outcomes of pregnancy complicated by idiopathic thrombocytopenic purpura. J Perinatol2010; 30: 38–44.
26. G.C.ChristiaensF.M.Helmerhorst. Validity of intrapartum diagnosis of fetal thrombocytopenia. Am J Obstet Gynecol1987; 157: 864–865.
27. V.M.1.AllenC.M.O’ConnellT.F.Baskett. Maternal and perinatal morbidity of caesarean delivery at full cervical dilatation compared with caesarean delivery in the first stage of labour. BJOG2005; 112: 986–990.
28. C.EkéusU.HögbergM.Norman. Vacuum assisted birth and risk for cerebral complications in term newborn infants: a population-based cohort study. BMC Preg Childbirth2014; 14: 36–36.
29. S.KoyomaT.TomimatsuT.Kanagawa. Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura. Am J Hematol2012; 87: 15–21.
30. K.KawaguchiK.MatsubaraT.Takafuta. Factors predictive of neonatal thrombocytopenia in pregnant women with immune thrombocytopenia. Int J Hematol2014; 99: 570–576.
31. G.L.ChristiaensH.K.NieuwenhuisA.K.Von Dem Borne. Idiopathic thrombocytopenic purpura in pregnancy: a randomized trial on the effect of antenatal low dose corticosteroids on neonatal platelet count. Br J Obstet Gynaecol1990; 97: 893–898.
32. J.N.GeorgeC.M.Nester. Syndromes of thrombotic microangiopathy. N Engl J Med2014; 371: 654–666.
33. M.ScullyM.ThomasM.Underwood. Thrombotic thrombocytopenic purpura and pregnancy: presentation, management and subsequent pregnancy outcomes. Blood2014; 124: 211–219.
34. M.Moatti-CohenC.GarrecM.Wolf. Unexpected frequency of Upshaw-Schulman syndrome in pregnancy-onset thrombotic thrombocytopenic purpura. Blood2012; 119: 5888–5897.
35. M.ScullyB.J.HuntS.Benjamin. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Hematol2012; 158: 323–335.
36. F.FakhouriL.RoumeninaF.Provot. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J Am Soc Nephrol2010; 21: 859–867.
37. R.F.BurrowsD.J.HunterM.Andrew. A prospective study investigating the mechanism of thrombocytopenia in preeclampsia. Obstet Gynecol1987; 70: 334–338.
38. K.HaramE.SvendsenU.Abildgaard. The HELLP syndrome: clinical issues and management. A review. BMC Preg Childbirth2009; 9: 8–8.
39. J.N.MartinJrC.H.RoseC.M.Briery. Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child. Am J Obstet Gynecol2006; 195: 914–934.
40. D.M.WoudstraS.ChandraG.J.Hofmeyr. Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. Cochrane Database Syst Rev2010; 9: CD008148–CD008148.
41. J.ThachilC.H.Toh. Disseminated intravascular coagulation in obstetric disorders and its acute haematological management. Blood Rev2009; 23: 167–176.
42. R.CerveraS.BucciarelliM.A.;.Plasin. for the Catastrophic Antiphospholipid Syndrome (CAPS) Registry Project Group (European Forum on Antiphospholipid Antibodies) Catastrophic antiphospholipid syndrome (CAPS): descriptive analysis of a series of 280 patients from the “CAPS Registry”. J Autoimmun2009; 32: 240–245.