Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: A multicenter prospective study

Blood

Volumn 118, Issue 17, 2011, Pages 4714-4718

  Pengo, Vittorio ^a   Ruffatti, Amelia ^a   Legnani, Cristina ^b   Testa, Sophie ^c   Fierro, Tiziana ^d   Marongiu, Francesco ^e   De Micheli, Valeria ^f   Gresele, Paolo ^d   Tonello, Marta ^a   Ghirarduzzi, Angelo ^g   Bison, Elisa ^a   Denas, Gentian ^a   Banzato, Alessandra ^a   Jose, Seena Padayattil ^a   Iliceto, Sabino ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c District Hospital   (Italy)

^d SANTA MARIA DELLA MISERICORDIA HOSPITAL   (Italy)

^e DEPARTMENT OF RADIOLOGY   (Italy)

^f District Hospital   (Italy)

^g S MARIA NUOVA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HIGH RISK POPULATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOEMBOLISM; VENOUS THROMBOEMBOLISM;

EID: 80055066032     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-03-340232     Document Type: Article

References (25)

1. Detkov PY, Gil-Aguado A, Lavilla P, et al. Do antibodies to beta2-glycoprotein 1 contribute to the better characterization of the antiphospholipid syndrome? Lupus. 1999;8(6):430-438. (Pubitemid 29423576)
2. Lee EY, Lee CK, Lee TH, et al. Does the anti-beta2-glycoprotein I antibody provide additional information in patients with thrombosis? Thromb Res. 2003;111(1):29-32. (Pubitemid 37485922)
3. Sailer T, Zoghlami C, Kurz C, et al. Anti-beta2-glycoprotein I antibodies are associated with pregnancy loss in women with the lupus anticoagulant. Thromb Haemost. 2006;95(5):796-801.
4. Zoghlami-Rintelen C, Vormittag R, Sailer T, et al. The presence of IgG antibodies against beta2-glycoprotein I predicts the risk of thrombosis in patients with the lupus anticoagulant. J Thromb Haemost. 2005;3(6):1160-1165. (Pubitemid 41725235)
5. Ruffatti A, Tonello M, Cavazzana A, et al. Laboratory classification categories and pregnancy outcome in patients with primary antiphospholipid syndrome prescribed antithrombotic therapy. Thromb Res. 2009;123(3):482-487.
6. Pengo V, Biasiolo A, Pegoraro C, et al. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost. 2005;93(6):147-152.
7. Pengo V, Ruffatti A, Legnani C, et al. Clinical course of high risk patients diagnosed with antiphospholipid syndrome (APS). J Thromb Haemost. 2009;8(2):237-242.
8. Pengo V, Tripodi A, Reber G, et al. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis: update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost. 2009;7(10):1737-1740.
9. Pengo V, Biasiolo A, Gresele P, et al. Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples. J Thromb Haemost. 2007;5(5):925-930. (Pubitemid 46691720)
10. Pengo V, Biasiolo A, Fior MG. Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when b2-glycoprotein-I is bound to a suitable surface. Thromb Haemost. 1995;73(1):29-34.
11. Tincani A, Allegri F, Balestrieri G, et al. Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. Thromb Res. 2004;114(5):553-558. (Pubitemid 39422591)
12. Reber G, Tincani A, Sanmarco M, et al. Proposal for the measurements of anti-b2-glycoprotein I antibodies: Standardization Group of the European Forum on Antiphospholipid Antibodies. J Thromb Haemost. 2004;2(10):1860-1862. (Pubitemid 40192732)
13. Barbhaiya M, Erkan D. Primary thrombosis prophylaxis in antiphospholipid antibody-positive patients: where do we stand? Curr Rheumatol Rep. 2011;13(1):59-69.
14. Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics: 2011 update. A report from the American Heart Association. Circulation. 2011;123(4):e18-e209.
15. Ruffatti A, Ross TD, Ciprian M, et al. Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. Ann Rheum Dis. 2011;70(6):1083-1086.
16. Mok CC, Tang SSK, To CH, et al. Incidence and risk factors of thromboembolism systemic lupus erythematosus: a comparison of three ethnic groups. Arthritis Rheum. 2005;52(9):2774-2782. (Pubitemid 41369106)
17. Erkan D, Harrison MJ, Levy R, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum. 2007;56(7):2382-2391. (Pubitemid 47173586)
18. Hereng T, Lambert M, Hachulla E, et al. Influence of aspirin on the clinical outcomes of 103 antiphospholipid phospholipid antibodies-positive patients. Lupus. 2008;17(1):11-15. (Pubitemid 351487013)
19. Giron-Gonzalez JA, Garcia del Rio E, Rodriguez C, et al. Antiphospholipid syndrome and asymptomatic carriers of antiphospholipid antibody: prospective analysis of 404 individuals. J Rheumatol. 2004;31(8):1560-1567. (Pubitemid 39006638)
20. Galli M, Borrelli G, Jacobsen EM, et al. Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study. Blood. 2007;110(4):1178-1183. (Pubitemid 47281414)
21. Pengo V. A contribution to the debate on the laboratory criteria that define the antiphospholipid syndrome. J Thromb Haemost. 2008;6(6):1-2.
22. Galli M, Luciani D, Bertolini G, et al. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003;101(5):1827-1832. (Pubitemid 36237580)
23. Pengo V, Biasiolo A, Gresele P, et al. A comparison of lupus anticoagulant-positive patients with clinical picture of antiphospholipid syndrome and those without. Arterioscler Thromb Vasc Biol. 2007;27(12):e309- e310. (Pubitemid 350158938)
24. de Groot PG, Lutters B, Derksen RH, et al. Lupus anticoagulants and the risk of a first episode of deep venous thrombosis. J Thromb Haemost. 2005;3(9):1993-1997. (Pubitemid 43086056)
25. McRae S, Tran H, Schulman S, et al. Effect of patient's sex on risk of recurrent venous thromboembolism: a meta-analysis. Lancet. 2006;368(9533):371- 378. (Pubitemid 44108120)