Ineffective quinidine therapy in early onset epileptic encephalopathy with KCNT1 mutation

Annals of Neurology

Volumn 79, Issue 3, 2016, Pages 502-503

  Chong, Pin Fee ^a   Nakamura, Ryoko ^a   Saitsu, Hirotomo ^b   Matsumoto, Naomichi ^b   Kira, Ryutaro ^a  

^a FUKUOKA CHILDREN S HOSPITAL   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

QUINIDINE; ANTIARRHYTHMIC AGENT; NERVE PROTEIN;

ANTICONVULSANT THERAPY; BENIGN CHILDHOOD EPILEPSY; BRAIN DISEASE; CASE REPORT; CHILD; DELTA RHYTHM; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG MONITORING; DRUG RESPONSE; DRUG TREATMENT FAILURE; ELECTROENCEPHALOGRAM; EPILEPTIC ENCEPHALOPATHY; GENE; GENE MUTATION; GENE SEQUENCE; GENETIC SCREENING; HETEROZYGOSITY; HUMAN; IMMOBILITY; KCNT1 GENE; KETOGENIC DIET; LETTER; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOMOTOR DEVELOPMENT; VAGUS NERVE STIMULATION; ANTAGONISTS AND INHIBITORS; EPILEPSIES, PARTIAL; FEMALE;

ANTI-ARRHYTHMIA AGENTS; EPILEPSIES, PARTIAL; FEMALE; HUMANS; NERVE TISSUE PROTEINS; QUINIDINE;

EID: 84960346192     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24598     Document Type: Letter

References (5)

1. Bearden D, Strong A, Ehnot J, et al., Targeted treatment of migrating partial seizures of infancy with quinidine. Ann Neurol 2014; 76: 457-461.
2. Milligan CJ, Li M, Gazina EV, et al., KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine. Ann Neurol 2014; 75: 581-590.
3. Ohba C, Kato M, Takahashi N, et al., De novo KCNT1 mutations in early-onset epileptic encephalopathy. Epilepsia 2015; 56: e121-e128.
4. Mikati MA, Jiang YH, Carboni M, et al., Quinidine in the treatment of KCNT1 positive epilepsies. Ann Neurol doi: 10.1002/ana.24520.
5. Ben-Ari Y, Holmes GL,. Effects of seizures on developmental processes in the immature brain. Lancet Neurol 2006; 5: 1055-1063.