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Volumn 10, Issue 4, 2015, Pages 97-106

The other woman: Evaluating the language of ‘three parent’ embryos

Author keywords

Egg donor; Gametes; Media; Mitochondrial donation; Three parent

Indexed keywords


EID: 84960344906     PISSN: 14777509     EISSN: 1758101X     Source Type: Journal    
DOI: 10.1177/1477750915599721     Document Type: Article
Times cited : (9)

References (75)
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    • The example of mitochondria might seem to be an exception to this rule, for it seems most probable that these structures developed from what were once independent organisms existing symbiotically within a host organism. So these ‘parts’ did exist before the ‘whole’. However, the transition here from endosymbiotic organisms (wholeto-whole relationship) to organelles (part-to-whole relationship) is utterly unlike manufacture. The parts were not produced separately, as parts, immediately prior to the assembly of the whole. Rather, the new kind of living organism evolves from previous living organisms (a whole evolving from wholes). In any case, mitochondria are now well-integrated parts of a whole, as they have been for well over a billion years. They are not organisms that could exist independently outside a cell
    • The example of mitochondria might seem to be an exception to this rule, for it seems most probable that these structures developed from what were once independent organisms existing symbiotically within a host organism. So these ‘parts’ did exist before the ‘whole’. However, the transition here from endosymbiotic organisms (wholeto-whole relationship) to organelles (part-to-whole relationship) is utterly unlike manufacture. The parts were not produced separately, as parts, immediately prior to the assembly of the whole. Rather, the new kind of living organism evolves from previous living organisms (a whole evolving from wholes). In any case, mitochondria are now well-integrated parts of a whole, as they have been for well over a billion years. They are not organisms that could exist independently outside a cell.
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    • For while MST starts with three gametes, combines elements of the two eggs, and generates one ‘three parent’ embryo by fertilisation, PNT starts with four gametes, generates two embryos by IVF, and then deconstructs these embryos. The PNT embryo is not itself generated by fertilisation, directly from gametes, but by reconstruction from two embryos, in a process very similar to somatic cell nuclear transfer (that is, cloning). PNT thus strains our understanding of biological parenthood perhaps to breaking point, notwithstanding that the embryo produced is very like an embryo generated by the ‘three parent’ MST technique
    • This paper focuses on MST because there are further complications in relation to PNT. For while MST starts with three gametes, combines elements of the two eggs, and generates one ‘three parent’ embryo by fertilisation, PNT starts with four gametes, generates two embryos by IVF, and then deconstructs these embryos. The PNT embryo is not itself generated by fertilisation, directly from gametes, but by reconstruction from two embryos, in a process very similar to somatic cell nuclear transfer (that is, cloning). PNT thus strains our understanding of biological parenthood perhaps to breaking point, notwithstanding that the embryo produced is very like an embryo generated by the ‘three parent’ MST technique.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.