IgM-enriched solution BT086 improves host defense capacity and energy store preservation in a rabbit model of endotoxemia

Acta Anaesthesiologica Scandinavica

Volumn 60, Issue 4, 2016, Pages 502-512

  Shmygalev, S ^a   Damm, M ^a   Knels, L ^b   Strassburg, A ^b   Wunsche K ^b   Dumke, R ^b   Stehr, S N ^c   Koch, T ^a   Heller, A R ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; BT 086; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN; SOLUTION AND SOLUBILITY;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; BACTERIAL CLEARANCE; BLOOD; CONTROLLED STUDY; ENDOTOXEMIA; ENERGY; ESCHERICHIA COLI; EXPERIMENTAL MODEL; GRANULOCYTE; HISTOPATHOLOGY; HOST RESISTANCE; LIVER; LUNG PARENCHYMA; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEPSIS; ANIMAL; DISEASE MODEL; HEMODYNAMICS; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY; RABBIT; RESPIRATORY BURST; SERUM BACTERICIDAL ACTIVITY; SOLUTION AND SOLUBILITY; THERAPEUTIC USE;

ANIMALS; BLOOD BACTERICIDAL ACTIVITY; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; HEMODYNAMICS; IMMUNOGLOBULIN M; IMMUNOGLOBULINS, INTRAVENOUS; NEUTROPHILS; PHAGOCYTOSIS; PHARMACEUTICAL SOLUTIONS; RABBITS; RESPIRATORY BURST;

EID: 84960342896     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/aas.12652     Document Type: Article

References (37)

1. Soares MO, Welton NJ, Harrison DA, Peura P, Shankar-Hari M, Harvey SE, Madan JJ, Ades AE, Palmer SJ, Rowan KM,. An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis. Health Technol Assess 2012; 16: 1-186.
2. Medzhitov R,. Origin and physiological roles of inflammation. Nature 2008; 454: 428-35.
3. Vianna RC, Gomes RN, Bozza FA, Amancio RT, Bozza PT, David CM, Castro-Faria-Neto HC,. Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release. Shock 2004; 21: 115-20.
4. Mignon F, Piagnerelli M, Van Nuffelen M, Vincent JL,. Effect of empiric antibiotic treatment on plasma endotoxin activity in septic patients. Infection 2014; 42: 521-8.
5. McCuskey RS, Nishida J, McDonnell D, Baker GL, Urbaschek R, Urbaschek B,. Effect of immunoglobulin G on the hepatic microvascular inflammatory response during sepsis. Shock 1996; 5: 28-33.
6. Raponi G, Lun MT, Gaeta A, Ghezzi MC, Nazzari C, Mancini C, Filadoro F, Bartolazzi A, Natali P, Rozenberg-Arska M,. Differential effect of human and murine polyclonal and monoclonal antisera on TNF-alpha production by human monocytes. J Chemother 1993; 5: 317-24.
7. Trautmann M, Held TK, Susa M, Karajan MA, Wulf A, Cross AS, Marre R,. Bacterial lipopolysaccharide (LPS)-specific antibodies in commercial human immunoglobulin preparations: superior antibody content of an IgM-enriched product. Clin Exp Immunol 1998; 111: 81-90.
8. Gelfand EW,. Intravenous immune globulin in autoimmune and inflammatory diseases. N Engl J Med 2012; 367: 2015-25.
9. Schwab I, Nimmerjahn F,. Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Nat Rev Immunol 2013; 13: 176-89.
10. Werdan K, Pilz G, Bujdoso O, Fraunberger P, Neeser G, Schmieder RE, Viell B, Marget W, Seewald M, Walger P, Stuttmann R, Speichermann N, Peckelsen C, Kurowski V, Osterhues HH, Verner L, Neumann R, Muller-Werdan U,. Score-Based Immunoglobulin Therapy of Sepsis Study G. Score-based immunoglobulin G therapy of patients with sepsis: the SBITS study. Crit Care Med 2007; 35: 2693-701.
11. Brocklehurst P, Farrell B, King A, Juszczak E, Darlow B, Haque K, Salt A, Stenson B, Tarnow-Mordi W,. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med 2011; 365: 1201-11.
12. Norrby-Teglund A, Haque KN, Hammarstrom L,. Intravenous polyclonal IgM-enriched immunoglobulin therapy in sepsis: a review of clinical efficacy in relation to microbiological aetiology and severity of sepsis. J Intern Med 2006; 260: 509-16.
13. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including The Pediatric S. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165-228.
14. Heller S, Weber K, Heller A, Urbaschek R, Koch T,. Pentoxifylline improves bacterial clearance during hemorrhage and endotoxemia. Crit Care Med 1999; 27: 756-63.
15. Stehr SN, Knels L, Weissflog C, Schober J, Haufe D, Lupp A, Koch T, Heller AR,. Effects of IGM-enriched solution on polymorphonuclear neutrophil function, bacterial clearance, and lung histology in endotoxemia. Shock 2008; 29: 167-72.
16. Instructions PHAGOTEST. [www document] Available at: http://www.glycotope.com/wp-content/uploads/documents/phagotst.pdf (accessed 07 January 2012).
17. Stehr SN, Weber S, Heller SC, Weikel J, Hubler M, Koch T, Heller AR,. N(omega)-nitro-L-arginine methyl ester effects on neutrophil function and bacterial clearance. Shock 2004; 22: 180-5.
18. Katzenstein AL, Bloor CM, Leibow AA,. Diffuse alveolar damage-the role of oxygen, shock, and related factors. A review. Am J Pathol 1976; 85: 209-28.
19. Ichikado K, Suga M, Gushima Y, Johkoh T, Iyonaga K, Yokoyama T, Honda O, Shigeto Y, Tomiguchi S, Takahashi M, Itoh H, Ikezoe J, Muller NL, Ando M,. Hyperoxia-induced diffuse alveolar damage in pigs: correlation between thin-section CT and histopathologic findings. Radiology 2000; 216: 531-8.
20. Broccard AF, Shapiro RS, Schmitz LL, Ravenscraft SA, Marini JJ,. Influence of prone position on the extent and distribution of lung injury in a high tidal volume oleic acid model of acute respiratory distress syndrome. Crit Care Med 1997; 25: 16-27.
21. Koch T, Heller S, Weber K, Heller A, Urbaschek R,. [Effects of human i.v. immunoglobulin on bacterial clearance and granulocyte function in endotoxinemia]. Anasthesiol Intensivmed Notfallmed Schmerzther 1997; 32: 420-5.
22. Alejandria MM, Lansang MA, Dans LF, Mantaring JB III,. Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock. Cochrane Database Syst Rev 2013; 9: CD001090.
23. Kreymann KG, de Heer G, Nierhaus A, Kluge S,. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. Crit Care Med 2007; 35: 2677-85.
24. Morrison DC, Silverstein R, Luchi M, Shnyra A,. Structure-function relationships of bacterial endotoxins. Contribution to microbial sepsis. Infect Dis Clin North Am 1999; 13: 313-40.
25. Heller AR, Heller SC, Borkenstein A, Stehr SN, Koch T,. Modulation of host defense by hydrocortisone in stress doses during endotoxemia. Intensive Care Med 2003; 29: 1456-63.
26. Fabrizio K, Groner A, Boes M, Pirofski LA,. A human monoclonal immunoglobulin M reduces bacteremia and inflammation in a mouse model of systemic pneumococcal infection. Clinical and vaccine immunology: CVI 2007; 14: 382-90.
27. Gomes RN, Teixeira-Cunha MG, Figueiredo RT, Almeida PE, Alves SC, Bozza PT, Bozza FA, Bozza MT, Zimmerman GA, Castro-Faria-Neto HC,. Bacterial clearance in septic mice is modulated by MCP-1/CCL2 and nitric oxide. Shock 2013; 39: 63-9.
28. Gille C, Dreschers S, Spring B, Tarnok A, Bocsi J, Poets CF, Orlikowsky TW,. Differential modulation of cord blood and peripheral blood monocytes by intravenous immunoglobulin. Cytometry B Clin Cytom 2012; 82: 26-34.
29. Tinguely C, Schaller M, Nydegger UE,. Mononuclear cells ingest E. coli opsonized by investigational intravenous immunoglobulin preparations in the absence of complement more efficiently than polymorphonuclear phagocytes. Transfus Apheres Sci 2001; 25: 43-50.
30. Danikas DD, Karakantza M, Theodorou GL, Sakellaropoulos GC, Gogos CA,. Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol 2008; 154: 87-97.
31. Rosas-Ballina M, Olofsson PS, Ochani M, Valdes-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ,. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 2011; 334: 98-101.
32. Angus DC, van der Poll T,. Severe sepsis and septic shock. N Engl J Med 2013; 369: 2063.
33. van der Poll T, Opal SM,. Host-pathogen interactions in sepsis. Lancet Infect Dis 2008; 8: 32-43.
34. Kazatchkine MD, Kaveri SV,. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med 2001; 345: 747-55.
35. Basta M, Van Goor F, Luccioli S, Billings EM, Vortmeyer AO, Baranyi L, Szebeni J, Alving CR, Carroll MC, Berkower I, Stojilkovic SS, Metcalfe DD,. F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. Nat Med 2003; 9: 431-8.
36. Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE,. Polyvalent immunoglobulin significantly attenuated the formation of IL-1beta in Escherichia coli-induced sepsis in pigs. Immunobiology 2013; 218: 683-9.
37. Mizock BA,. Alterations in carbohydrate metabolism during stress: a review of the literature. Am J Med 1995; 98: 75-84.