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Volumn 128, Issue 1, 2016, Pages 35-45

MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway

Author keywords

C19MC; Glioblastoma; miR 519a; STAT3

Indexed keywords

MICRORNA; MICRORNA 519A; STAT3 PROTEIN; UNCLASSIFIED DRUG; MIRN519 MICRORNA, HUMAN; STAT3 PROTEIN, HUMAN;

EID: 84960327560     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-016-2095-z     Document Type: Article
Times cited : (38)

References (37)
  • 1
    • 84885706199 scopus 로고    scopus 로고
    • Angiogenesis in glioblastoma
    • COI: 1:CAS:528:DC%2BC3sXhs1CgsbjP, PID: 24131182
    • Das S, Marsden PA (2013) Angiogenesis in glioblastoma. N Engl J Med 369:1561–1563
    • (2013) N Engl J Med , vol.369 , pp. 1561-1563
    • Das, S.1    Marsden, P.A.2
  • 2
    • 84861697198 scopus 로고    scopus 로고
    • Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights
    • PID: 22002595
    • Ng K, Kim R, Kesari S, Carter B, Chen CC (2012) Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights. J Neurooncol 107:1–12
    • (2012) J Neurooncol , vol.107 , pp. 1-12
    • Ng, K.1    Kim, R.2    Kesari, S.3    Carter, B.4    Chen, C.C.5
  • 3
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • COI: 1:CAS:528:DC%2BD28XktVOitbw%3D, PID: 18039109
    • Louis DN (2006) Molecular pathology of malignant gliomas. Annu Rev Pathol 1:97–117
    • (2006) Annu Rev Pathol , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 4
    • 51049123447 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas
    • COI: 1:CAS:528:DC%2BD1cXmt1Ojs7s%3D, PID: 18505913
    • Brantley EC, Benveniste EN (2008) Signal transducer and activator of transcription-3: a molecular hub for signaling pathways in gliomas. Mol Cancer Res 6:675–684
    • (2008) Mol Cancer Res , vol.6 , pp. 675-684
    • Brantley, E.C.1    Benveniste, E.N.2
  • 7
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • COI: 1:CAS:528:DC%2BD38Xpt1WitLo%3D, PID: 12466961
    • Rahaman SO, Harbor PC, Chernova O, Barnett GH, Vogelbaum MA, Haque SJ (2002) Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 21:8404–8413
    • (2002) Oncogene , vol.21 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3    Barnett, G.H.4    Vogelbaum, M.A.5    Haque, S.J.6
  • 8
    • 79952189765 scopus 로고    scopus 로고
    • Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
    • COI: 1:CAS:528:DC%2BC3MXptFCmsA%3D%3D, PID: 20589525
    • Senft C, Priester M, Polacin M, Schroder K, Seifert V, Kogel D, Weissenberger J (2011) Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells. J Neurooncol 101:393–403
    • (2011) J Neurooncol , vol.101 , pp. 393-403
    • Senft, C.1    Priester, M.2    Polacin, M.3    Schroder, K.4    Seifert, V.5    Kogel, D.6    Weissenberger, J.7
  • 9
    • 58149144782 scopus 로고    scopus 로고
    • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators
    • COI: 1:CAS:528:DC%2BD1cXhtF2nurrJ, PID: 18829483
    • Lo HW, Cao X, Zhu H, Ali-Osman F (2008) Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. Clin Cancer Res 14:6042–6054
    • (2008) Clin Cancer Res , vol.14 , pp. 6042-6054
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4
  • 11
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • COI: 1:CAS:528:DC%2BD1MXhs1Kiuro%3D, PID: 19167326
    • Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136:215–233
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 12
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • COI: 1:CAS:528:DC%2BD28XhtFWhs7fM, PID: 17060945
    • Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6:857–866
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 14
    • 79955514336 scopus 로고    scopus 로고
    • A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs
    • COI: 1:CAS:528:DC%2BC3MXltlGhurs%3D, PID: 21385897
    • Kim TM, Huang W, Park R, Park PJ, Johnson MD (2011) A developmental taxonomy of glioblastoma defined and maintained by MicroRNAs. Cancer Res 71:3387–3399
    • (2011) Cancer Res , vol.71 , pp. 3387-3399
    • Kim, T.M.1    Huang, W.2    Park, R.3    Park, P.J.4    Johnson, M.D.5
  • 15
    • 78449302631 scopus 로고    scopus 로고
    • Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours
    • PID: 21083603
    • Kim TH, Kim YK, Kwon Y, Heo JH, Kang H, Kim G, An HJ (2010) Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. Histopathology 57:734–743
    • (2010) Histopathology , vol.57 , pp. 734-743
    • Kim, T.H.1    Kim, Y.K.2    Kwon, Y.3    Heo, J.H.4    Kang, H.5    Kim, G.6    An, H.J.7
  • 16
    • 84904259547 scopus 로고    scopus 로고
    • MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer
    • COI: 1:CAS:528:DC%2BC2cXhtFKmt7%2FI, PID: 24752803
    • Ward A, Shukla K, Balwierz A, Soons Z, Konig R, Sahin O, Wiemann S (2014) MicroRNA-519a is a novel oncomir conferring tamoxifen resistance by targeting a network of tumour-suppressor genes in ER+ breast cancer. J Pathol 233:368–379
    • (2014) J Pathol , vol.233 , pp. 368-379
    • Ward, A.1    Shukla, K.2    Balwierz, A.3    Soons, Z.4    Konig, R.5    Sahin, O.6    Wiemann, S.7
  • 17
    • 84873907356 scopus 로고    scopus 로고
    • Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma
    • PID: 23082062
    • Wang W, Zhao LJ, Tan YX, Ren H, Qi ZT (2012) Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol 18:5442–5453
    • (2012) World J Gastroenterol , vol.18 , pp. 5442-5453
    • Wang, W.1    Zhao, L.J.2    Tan, Y.X.3    Ren, H.4    Qi, Z.T.5
  • 19
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • COI: 1:CAS:528:DC%2BD2cXotl2hu7w%3D, PID: 15364901
    • Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res 14:1902–1910
    • (2004) Genome Res , vol.14 , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 21
    • 84862918595 scopus 로고    scopus 로고
    • Glioblastoma with PNET-like components has a higher frequency of isocitrate dehydrogenase 1 (IDH1) mutation and likely a better prognosis than primary glioblastoma
    • COI: 1:CAS:528:DC%2BC3MXhsFKqtbzN, PID: 22076165
    • Song X, Andrew Allen R, Terence Dunn S, Fung KM, Farmer P, Gandhi S, Ranjan T, Demopoulos A, Symons M, Schulder M, Li JY (2011) Glioblastoma with PNET-like components has a higher frequency of isocitrate dehydrogenase 1 (IDH1) mutation and likely a better prognosis than primary glioblastoma. Int J Clin Exp Pathol 4:651–660
    • (2011) Int J Clin Exp Pathol , vol.4 , pp. 651-660
    • Song, X.1    Andrew Allen, R.2    Terence Dunn, S.3    Fung, K.M.4    Farmer, P.5    Gandhi, S.6    Ranjan, T.7    Demopoulos, A.8    Symons, M.9    Schulder, M.10    Li, J.Y.11
  • 23
    • 77955172153 scopus 로고    scopus 로고
    • miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer
    • COI: 1:CAS:528:DC%2BC3cXms1yntbw%3D, PID: 20514023
    • Uhlmann S, Zhang JD, Schwager A, Mannsperger H, Riazalhosseini Y, Burmester S, Ward A, Korf U, Wiemann S, Sahin O (2010) miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. Oncogene 29:4297–4306
    • (2010) Oncogene , vol.29 , pp. 4297-4306
    • Uhlmann, S.1    Zhang, J.D.2    Schwager, A.3    Mannsperger, H.4    Riazalhosseini, Y.5    Burmester, S.6    Ward, A.7    Korf, U.8    Wiemann, S.9    Sahin, O.10
  • 24
  • 25
    • 84892453256 scopus 로고    scopus 로고
    • Identification of intrinsic subtype-specific prognostic microRNAs in primary glioblastoma
    • PID: 24438238
    • Li R, Gao K, Luo H, Wang X, Shi Y, Dong Q, Luan W, You Y (2014) Identification of intrinsic subtype-specific prognostic microRNAs in primary glioblastoma. J Exp Clin Cancer Res 33:9
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 9
    • Li, R.1    Gao, K.2    Luo, H.3    Wang, X.4    Shi, Y.5    Dong, Q.6    Luan, W.7    You, Y.8
  • 27
    • 79955702339 scopus 로고    scopus 로고
    • Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3MXlvVyntLc%3D, PID: 21549324
    • Lathia JD, Heddleston JM, Venere M, Rich JN (2011) Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 8:482–485
    • (2011) Cell Stem Cell , vol.8 , pp. 482-485
    • Lathia, J.D.1    Heddleston, J.M.2    Venere, M.3    Rich, J.N.4
  • 28
    • 84862025220 scopus 로고    scopus 로고
    • The dark side of a success story: microRNAs of the C19MC cluster in human tumours
    • COI: 1:CAS:528:DC%2BC38XotVOltrs%3D, PID: 22374805
    • Flor I, Bullerdiek J (2012) The dark side of a success story: microRNAs of the C19MC cluster in human tumours. J Pathol 227:270–274
    • (2012) J Pathol , vol.227 , pp. 270-274
    • Flor, I.1    Bullerdiek, J.2
  • 29
    • 84872716806 scopus 로고    scopus 로고
    • The two faces of Janus kinases and their respective STATs in mammary gland development and cancer
    • PID: 22279417
    • Wagner KU, Schmidt JW (2011) The two faces of Janus kinases and their respective STATs in mammary gland development and cancer. J Carcinog 10:32
    • (2011) J Carcinog , vol.10 , pp. 32
    • Wagner, K.U.1    Schmidt, J.W.2
  • 30
    • 51049089073 scopus 로고    scopus 로고
    • Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression
    • COI: 1:CAS:528:DC%2BD1cXpt1ejsb8%3D, PID: 18676737
    • Brantley EC, Nabors LB, Gillespie GY, Choi YH, Palmer CA, Harrison K, Roarty K, Benveniste EN (2008) Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression. Clin Cancer Res 14:4694–4704
    • (2008) Clin Cancer Res , vol.14 , pp. 4694-4704
    • Brantley, E.C.1    Nabors, L.B.2    Gillespie, G.Y.3    Choi, Y.H.4    Palmer, C.A.5    Harrison, K.6    Roarty, K.7    Benveniste, E.N.8
  • 31
    • 84898777523 scopus 로고    scopus 로고
    • STAT3 Tyr705 phosphorylation affects clinical outcome in patients with newly diagnosed supratentorial glioblastoma
    • PID: 24652192
    • Lin GS, Yang LJ, Wang XF, Chen YP, Tang WL, Chen L, Lin ZX (2014) STAT3 Tyr705 phosphorylation affects clinical outcome in patients with newly diagnosed supratentorial glioblastoma. Med Oncol 31:924
    • (2014) Med Oncol , vol.31 , pp. 924
    • Lin, G.S.1    Yang, L.J.2    Wang, X.F.3    Chen, Y.P.4    Tang, W.L.5    Chen, L.6    Lin, Z.X.7
  • 32
    • 78449312044 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation influences survival in glioblastoma
    • COI: 1:CAS:528:DC%2BC3cXhtlant77J, PID: 20455003
    • Birner P, Toumangelova-Uzeir K, Natchev S, Guentchev M (2010) STAT3 tyrosine phosphorylation influences survival in glioblastoma. J Neurooncol 100:339–343
    • (2010) J Neurooncol , vol.100 , pp. 339-343
    • Birner, P.1    Toumangelova-Uzeir, K.2    Natchev, S.3    Guentchev, M.4
  • 33
    • 0028349735 scopus 로고
    • Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • COI: 1:CAS:528:DyaK2cXlt1Kktrk%3D, PID: 8140422
    • Zhong Z, Wen Z, Darnell JE Jr (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 264:95–98
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell, J.E.3
  • 34
    • 0038724743 scopus 로고    scopus 로고
    • Regulators of G1 cyclin-dependent kinases and cancers
    • COI: 1:CAS:528:DC%2BD3sXjslyiu7k%3D, PID: 12884917
    • Lee MH, Yang HY (2003) Regulators of G1 cyclin-dependent kinases and cancers. Cancer Metastasis Rev 22:435–449
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 435-449
    • Lee, M.H.1    Yang, H.Y.2
  • 36
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • COI: 1:CAS:528:DC%2BC3cXlsVSgtb4%3D, PID: 20371345
    • Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52–67
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 37
    • 84883850357 scopus 로고    scopus 로고
    • Human chorionic gonadotropin beta induces cell motility via ERK1/2 and MMP-2 activation in human glioblastoma U87MG cells
    • COI: 1:CAS:528:DC%2BC3sXit1Gqsbo%3D, PID: 23232806
    • Li Z, Du L, Li C, Wu W (2013) Human chorionic gonadotropin beta induces cell motility via ERK1/2 and MMP-2 activation in human glioblastoma U87MG cells. J Neurooncol 111:237–244
    • (2013) J Neurooncol , vol.111 , pp. 237-244
    • Li, Z.1    Du, L.2    Li, C.3    Wu, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.