Combinations of potent topical steroids, mercury and hydroquinone are common in internationally manufactured skin-lightening products: A spectroscopic study

Clinical and Experimental Dermatology

Volumn 41, Issue 2, 2016, Pages 196-201

  Maneli, M H ^a   Wiesner, L ^a   Tinguely, C ^b   Davids, L M ^b   Spengane, Z ^a   Smith, P ^a   Van Wyk, J C ^a   Jardine, A ^b   Khumalo, Nonhlanhla P ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CLOBETASOL PROPIONATE; COSMETIC; DEPIGMENTING AGENT; HYDROQUINONE; MERCURY; STEROID; CLOBETASOL; HYDROQUINONE DERIVATIVE; KOJIC ACID; PYRONE DERIVATIVE;

ARTICLE; CONGO; CONTROLLED STUDY; COSMETIC INDUSTRY; COTE D'IVOIRE; FRANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDIA; ITALY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SOUTH AFRICA; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET SPECTROPHOTOMETRY; UNITED KINGDOM; UNITED STATES; CHEMISTRY;

BETAMETHASONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOBETASOL; HYDROQUINONES; MASS SPECTROMETRY; MERCURY; PYRONES; SKIN LIGHTENING PREPARATIONS; SOUTH AFRICA; SPECTROPHOTOMETRY, ULTRAVIOLET; STEROIDS;

EID: 84960307751     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/ced.12720     Document Type: Article

References (26)

1. Rendon MI, Gaviria JI,. Review of skin-lightening agents. Dermatol Surg 2005; 31: 886-9; discussion 9.
2. Berardesca E, Ardigò M, Berardesca M, Cameli N,. Melasma: current and future treatments. Exp Rev Dermatol 2008; 3: 187-93.
3. Imadojemu S, Fiester A,. Skin bleaching as a dermatologic intervention: complicity or service? JAMA Dermatol 2013; 149: 901-2.
4. Ebanks JP, Wickett RR, Boissy RE,. Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration. Int J Mol Sci 2009; 10: 4066-87.
5. Al-Saleh I, Elkhatib R, Al-Rouqi R, et al,. The dangers of skin-lightening creams. Toxicol Environ Chem 2012; 94: 195-219.
6. Gillbro J, Olsson M,. The melanogenesis and mechanisms of skin-lightening agents-existing and new approaches. Int J Cosmet Sci 2011; 33: 210-21.
7. de Souza MM,. The concept of skin bleaching in Africa and its devastating health implications. Clin Dermatol 2008; 26: 27-9.
8. Olumide YM, Akinkugbe AO, Altraide D, Mohammed T, Ahamefule N, Ayanlowo S, et al,. Complications of chronic use of skin lightening cosmetics. Int J Dermatol 2008; 47: 344-53.
9. Del Giudice P, Yves P,. The widespread use of skin lightening creams in Senegal: a persistent public health problem in West Africa. Int J Dermatol 2002; 41: 69-72.
10. Findlay GH, Morrison JG, Simson IW,. Exogenous ochronosis and pigmented colloid milium from hydroquinone bleaching creams. Br J Dermatol 1975; 93: 613-22.
11. Findlay GH, De Beer HA,. Chronic hydroquinone poisoning of the skin from skin-lightening cosmetics. A South African epidemic of ochronosis of the face in dark-skinned individuals. S Afr Med J 1980; 57: 187-90.
12. Ord L,. The dark side of skin creams. 2008. Available at: http://www.iol.co.za/lifestyle/the-dark-side-of-skin-creams-1.623999?ot&inmsa.ArticlePrintPageLayout.ot (accessed 25 February 2015).
13. Bocca B, Pino A, Alimonti A, Forte G,. Toxic metals contained in cosmetics: a status report. Regul Toxicol Pharmacol 2014; 68: 447-67.
14. Chan TY,. Inorganic mercury poisoning associated with skin-lightening cosmetic products. Clin Toxicol (Phila) 2011; 49: 886-91.
15. Glenn EN,. Yearning for lightness transnational circuits in the marketing and consumption of skin lighteners. Gend Soc 2008; 22: 281-302.
16. Directive BC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products. 2003. Available at: http://nordhealth.cn/uploads/soft/140731/cosmetics-directive-76-768-eec.pdf (accessed 17 March 2015).
17. Buzek J, Ask B,. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Official J Eur Union 2009; L342/59-209.
18. Madlala M,. Warnings against use of illegal cosmetics. 2012. Available at: http://www.iol.co.za/dailynews/news/warnings-against-use-of-illegal-cosmetics-1.1309747#.VPX2Rd5yaHt (accessed 25 February 2015).
19. Dlova NC, Hendricks NE, Martincgh BS,. Skin-lightening creams used in Durban, South Africa. Int J Dermatol 2012; 51 (Suppl. 1): 51-3.
20. Gabler ERS,. Some skin whitening creams contain toxic mercury, testing finds. 2010. Available at: http://articles.chicagotribune.com/2010-05-18/health/ct-met-mercury-skin-creams-20100518-1-tribune-tests-six-creams-ira-allen/2 (accessed 25 February 2015).
21. Hamann CR, Boonchai W, Wen L, et al,. Spectrometric analysis of mercury content in 549 skin-lightening products: is mercury toxicity a hidden global health hazard? J Am Acad Dermatol 2014; 70: 281-7. e3.
22. Graeme M, Kimberlie A, Pollack M Jr, Charles V,. Heavy metal toxicity, part I: arsenic and mercury. J Emerg Med 1998; 16: 45-56.
23. Boyd AS, Seger D, Vannucci S, et al,. Mercury exposure and cutaneous disease. J Am Acad Dermatol 2000; 43: 81-90.
24. Kligman AM, Willis I,. A new formula for depigmenting human skin. Arch Dermatol 1975; 111: 40-8.
25. Nnoruka E, Okoye O,. Topical steroid abuse: its use as a depigmenting agent. J Nat Med Assoc 2006; 98: 934.
26. Saxberg BE, Kowalski BR,. Generalized standard addition method. Anal Chem 1979; 51: 1031-8.