Warfarin and Vascular Calcification

American Journal of Medicine

Volumn 129, Issue 6, 2016, Pages 635.e1-635.e4

  Poterucha, Timothy J ^a   Goldhaber, Samuel Z ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Matrix gamma carboxyglutamate Gla protein; Vascular calcification; Warfarin

Indexed keywords

4 CARBOXYGLUTAMIC ACID; MATRIX GAMMA CARBOXYGLUTAMATE GLA PROTEIN; OSTEOCALCIN; UNCLASSIFIED DRUG; WARFARIN; ANTICOAGULANT AGENT; CALCIUM BINDING PROTEIN; MATRIX GLA PROTEIN; SCLEROPROTEIN; VITAMIN K GROUP;

BLOOD VESSEL CALCIFICATION; BONE DENSITY; BONE MINERALIZATION; CARBOXYLATION; CHRONIC KIDNEY DISEASE; HEMODIALYSIS PATIENT; HIGH RISK PATIENT; HUMAN; LUNG EMBOLISM; NONHUMAN; PRIORITY JOURNAL; REVIEW; VITAMIN K METABOLISM; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; COMPLICATION; DIAGNOSTIC IMAGING; DRUG EFFECTS; FEMALE; MALE; MAMMOGRAPHY; PROCEDURES;

ANTICOAGULANTS; BONE DENSITY; CALCIUM-BINDING PROTEINS; EXTRACELLULAR MATRIX PROTEINS; FEMALE; HUMANS; MALE; MAMMOGRAPHY; VASCULAR CALCIFICATION; VITAMIN K; WARFARIN;

EID: 84960194419     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2015.11.032     Document Type: Review

References (23)

1. B. Weijs, Y. Blaauw, R.J. Rennenberg, and et al. Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients Eur Heart J 32 20 2011 2555 2562
2. R.C. Johnson, J.A. Leopold, and J. Loscalzo Vascular calcification: pathobiological mechanisms and clinical implications Circ Res 99 10 2006 1044 1059
3. G. Luo, P. Ducy, M.D. McKee, and et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein Nature 386 6620 1997 78 81
4. L.J. Schurgers, H.M. Spronk, J.N. Skepper, and et al. Post-translational modifications regulate matrix gla protein function: Importance for inhibition of vascular smooth muscle cell calcification J Thromb Haemost 5 12 2007 2503 2511
5. E.C. Cranenburg, R. Koos, L.J. Schurgers, and et al. Characterisation and potential diagnostic value of circulating matrix gla protein (MGP) species Thromb Haemost 104 4 2010 811 822
6. G. Schlieper, R. Westenfeld, T. Kruger, and et al. Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD J Am Soc Nephrol 22 2 2011 387 395
7. P.A. Price, S.A. Faus, and M.K. Williamson Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves Arterioscler Thromb Vasc Biol 18 9 1998 1400 1407
8. T. Kruger, S. Oelenberg, N. Kaesler, and et al. Warfarin induces cardiovascular damage in mice Arterioscler Thromb Vasc Biol 33 11 2013 2618 2624
9. L.J. Schurgers, I.A. Joosen, E.M. Laufer, and et al. Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype PLoS One 7 8 2012 e43229
10. L.J. Schurgers, H.M. Spronk, B.A. Soute, P.M. Schiffers, J.G. DeMey, and C. Vermeer Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats Blood 109 7 2007 2823 2831
11. G.W. Dalmeijer, Y.T. van der Schouw, E.J. Magdeleyns, and et al. Circulating species of matrix gla protein and the risk of vascular calcification in healthy women Int J Cardiol 168 6 2013 e168 e170
12. R.J. Rennenberg, B.J. van Varik, L.J. Schurgers, and et al. Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans Blood 115 24 2010 5121 5123
13. E. Tantisattamo, K.H. Han, and W.C. O'Neill Increased vascular calcification in patients receiving warfarin Arterioscler Thromb Vasc Biol 35 1 2015 237 242
14. L.J. Schurgers, D.V. Barreto, F.C. Barreto, and et al. The circulating inactive form of matrix gla protein is a surrogate marker for vascular calcification in chronic kidney disease: a preliminary report Clin J Am Soc Nephrol 5 4 2010 568 575
15. M. Fusaro, G. Tripepi, M. Noale, and et al. Prevalence of vertebral fractures, vascular calcifications, and mortality in warfarin treated hemodialysis patients Curr Vasc Pharmacol 13 2 2015 248 258
16. R. Westenfeld, T. Krueger, G. Schlieper, and et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial Am J Kidney Dis 59 2 2012 186 195
17. L. Eckersley, J. Stirling, C. Occleshaw, and N. Wilson Two cases of warfarin-induced tracheobronchial calcification after Fontan surgery Pediatr Cardiol 35 6 2014 954 958
18. M. Meier, L.P. Weng, E. Alexandrakis, J. Ruschoff, and G. Goeckenjan Tracheobronchial stenosis in Keutel syndrome Eur Respir J 17 3 2001 566 569
19. R.K. Menon, D.S. Gill, M. Thomas, P.B. Kernoff, and P. Dandona Impaired carboxylation of osteocalcin in warfarin-treated patients J Clin Endocrinol Metab 64 1 1987 59 61
20. M. Fusaro, L. Dalle Carbonare, A. Dusso, and et al. Differential effects of dabigatran and warfarin on bone volume and structure in rats with normal renal function PLoS One 10 8 2015 e0133847
21. Z. Rezaieyazdi, H. Falsoleiman, M. Khajehdaluee, M. Saghafi, and E. Mokhtari-Amirmajdi Reduced bone density in patients on long-term warfarin Int J Rheum Dis 12 2 2009 130 135
22. C. Barnes, F. Newall, V. Ignjatovic, and et al. Reduced bone density in children on long-term warfarin Pediatr Res 57 4 2005 578 581
23. S. Tanaka, T. Miyazaki, Y. Uemura, and et al. Design of a randomized clinical trial of concurrent treatment with vitamin K2 and risedronate compared to risedronate alone in osteoporotic patients: Japanese osteoporosis intervention trial-03 (JOINT-03) J Bone Miner Metab 32 3 2014 298 304