Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population

BMJ Open

Volumn 6, Issue 1, 2016, Pages

  Li, Zhiming ^a   Zhong, Li ^a   Gu, Long ^a   Huang, Wenqing ^a   Shi, Xinzhen ^a   Zhang, Xilin ^a   An, Xingkai ^b   Lin, Qing ^a,b   Tzeng, Chi Meng ^a  

^a XIAMEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

ADULT; ARTICLE; CHINA; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HAN CHINESE; HUMAN; LEUKOARAIOSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR BEACON; OUTCOME ASSESSMENT; PARKINSON DISEASE; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; WHITE MATTER LESION; AGED; ALZHEIMER DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; CHONDRODYSPLASIA; ETHNIC GROUP; GENETICS; LIPODYSTROPHY; MUTATION; PATHOLOGY; SUBACUTE SCLEROSING PANENCEPHALITIS; WHITE MATTER;

AGED; ALZHEIMER DISEASE; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; ETHNIC GROUPS; FEMALE; GENOTYPE; HUMANS; LIPODYSTROPHY; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MUTATION; OSTEOCHONDRODYSPLASIAS; PARKINSON DISEASE; POLYMORPHISM, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, IMMUNOLOGIC; SUBACUTE SCLEROSING PANENCEPHALITIS; WHITE MATTER;

EID: 84960173016     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2015-009499     Document Type: Article

References (16)

1. Colonna M. TREMs in the immune system and beyond. Nat Rev Immunol 2003;3:445-53.
2. Hsieh CL, Koike M, Spusta SC, et al. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem 2009;109:1144-56.
3. Guerreiro R, Wojtas A, Bras J, et al. TREM2 variants in Alzheimer's disease. N Engl J Med 2013;368:117-27.
4. Cuyvers E, Bettens K, Philtjens S, et al. BELNEU consortium. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. Neurobiol Aging 2014;35:726.e11-19.
5. Rosenthal SL, Bamne MN, Wang X, et al. More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk. Neurobiol Aging 2015;36:2443.e21-6.
6. Rayaprolu S, Mullen B, Baker M, et al. TREM2 in neurodegeneration: evidence for association of the p. R47H variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener 2013;8:19.
7. Jonsson T, Stefansson K. TREM2 and neurodegenerative disease. N Engl J Med 2013;369:1568-9.
8. Klünemann HH, Ridha BH, Magy L, et al. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology 2005;64:1502-7.
9. Ma Q, An X, Li Z, et al. P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population. Behav Brain Funct 2013;9:19.
10. Feng SJ, Nie K, Gan R, et al. Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort. Neurobiol Aging 2014;35:1780.e11-12.
11. Yu JT, Jiang T, Wang YL, et al. Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals. Neurobiol Aging 2014;35:937.e1-3.
12. Jonsson T, Stefansson H, Steinberg S, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013;368:107-16.
13. Pottier C, Wallon D, Rousseau S, et al. TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. J Alzheimers Dis 2013;35:45-9.
14. Benitez BA, Cooper B, Pastor P, et al. TREM2 is associated with the risk of Alzheimer's disease in Spanish population. Neurobiol Aging 2013;34:1711.e15-17.
15. Bohnen NI, Albin RL. White matter lesions in Parkinson disease. Nat Rev Neurol 2011;7:229-36.
16. Miyashita A, Wen Y, Kitamura N, et al. Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population. J Alzheimers Dis 2014;41:1031-8.