Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

Nature Medicine

Volumn 22, Issue 4, 2016, Pages 427-432

  Camarda, Roman ^a   Zhou, Alicia Y ^a   Kohnz, Rebecca A ^b   Balakrishnan, Sanjeev ^a   Mahieu, Celine ^a   Anderton, Brittany ^a   Eyob, Henok ^a   Kajimura, Shingo ^a   Tward, Aaron ^c   Krings, Gregor ^c   Nomura, Daniel K ^b   Goga, Andrei ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BETA ACTIN; ETOMOXIR; FATTY ACID SYNTHASE; MESSENGER RNA; MYC PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOENERGY; CANCER CELL; CANCER GROWTH; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENERGY METABOLISM; ENERGY YIELD; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIPID METABOLISM; MAJOR CLINICAL STUDY; MAMMARY GLAND FAT; METABOLOMICS; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION; BIOSYNTHESIS; CARCINOGENESIS; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS; CARCINOGENESIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENERGY METABOLISM; FATTY ACIDS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID METABOLISM; OXIDATION-REDUCTION; PROTO-ONCOGENE PROTEINS C-MYC; TRIPLE NEGATIVE BREAST NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84960172342     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4055     Document Type: Article

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