A New Class of Safe Oligosaccharide Polymer Therapy to Modify the Mucus Barrier of Chronic Respiratory Disease

Molecular Pharmaceutics

Volumn 13, Issue 3, 2016, Pages 863-872

  Pritchard, Manon F ^a,b   Powell, Lydia C ^a,b   Menzies, Georgina E ^b   Lewis, Paul D ^b   Hawkins, Karl ^b   Wright, Chris ^b   Doull, Iolo ^c   Walsh, Timothy R ^a   Onsøyen, Edvar ^d   Dessen, Arne ^d   Myrvold, Rolf ^d   Rye, Philip D ^d   Myrset, Astrid H ^d   Stevens, Howard N E ^e   Hodges, Lee A ^e   MacGregor, Gordon ^f   Neilly, James B ^g   Hill, Katja E ^a   Thomas, David W ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c CHILDREN S HOSPITAL FOR WALES   (United Kingdom)

^d ALGIPHARMA AS   (Norway)

^e Bio Images Research Ltd   (United Kingdom)

^f GARTNAVEL GENERAL HOSPITAL   (United Kingdom)

^g GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

alginate; cystic fibrosis; mucin; polymer therapy; safety; sputum; viscoelasticity

Indexed keywords

ALGINIC ACID; BIOPOLYMER; MUCIN; OLIGOSACCHARIDE; OLIGOSACCHARIDE G CF-5/20; STOMACH MUCIN; UNCLASSIFIED DRUG; GLUCURONIC ACID; HEXURONIC ACID; POLYMER;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CHRONIC RESPIRATORY TRACT DISEASE; CYSTIC FIBROSIS; DRUG DELIVERY SYSTEM; HUMAN; INFRARED SPECTROSCOPY; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR WEIGHT; MULTICENTER STUDY (TOPIC); NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCANNING ELECTRON MICROSCOPY; SPUTUM; SURFACE CHARGE; VISCOELASTICITY; ADOLESCENT; ADULT; ANIMAL; ATOMIC FORCE MICROSCOPY; CHEMISTRY; CHRONIC DISEASE; FEMALE; FLOW KINETICS; MALE; METABOLISM; MUCUS; PIG; RAT; SPRAGUE DAWLEY RAT; YOUNG ADULT;

ADOLESCENT; ADULT; ALGINATES; ANIMALS; CHRONIC DISEASE; CLINICAL TRIALS, PHASE I AS TOPIC; CYSTIC FIBROSIS; FEMALE; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MALE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; MUCINS; MUCUS; OLIGOSACCHARIDES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RHEOLOGY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPUTUM; SWINE; YOUNG ADULT;

EID: 84960156287     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00794     Document Type: Article

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