Size-Tuning Ionization to Optimize Gold Nanoparticles for Simultaneous Enhanced CT Imaging and Radiotherapy

ACS Nano

Volumn 10, Issue 2, 2016, Pages 2536-2548

  Dou, Yan ^a   Guo, Yanyan ^b   Li, Xiaodong ^b   Li, Xue ^b   Wang, Sheng ^a   Wang, Lin ^b   Lv, Guoxian ^a   Zhang, Xuening ^b   Wang, Hanjie ^a   Gong, Xiaoqun ^a   Chang, Jin ^a  

^a TIANJIN UNIVERSITY   (China)

^b SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

AuNPs; CT imaging; Monte Carlo simulations; radiosensitization; size tuning ionization; X ray theranostics

Indexed keywords

FIBER OPTIC SENSORS; GOLD; INTELLIGENT SYSTEMS; IONIZATION; METAL NANOPARTICLES; MONTE CARLO METHODS; NANOPARTICLES; RADIOTHERAPY; TUMORS;

AUNPS; CT IMAGING; RADIO-SENSITIZATION; SIZE TUNING; THERANOSTICS;

COMPUTERIZED TOMOGRAPHY;

GOLD; METAL NANOPARTICLE;

ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DIAGNOSTIC IMAGING; FEMALE; HELA CELL LINE; HUMAN; MONTE CARLO METHOD; MOUSE; NEOPLASMS; NUDE MOUSE; RADIATION RESPONSE; X-RAY COMPUTED TOMOGRAPHY;

ANIMALS; FEMALE; GOLD; HELA CELLS; HUMANS; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; MICE, NUDE; MONTE CARLO METHOD; NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED; X-RAY THERAPY;

EID: 84960155846     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b07473     Document Type: Article

References (52)

1. Canellos, G. P. Clinical Oncology: Onward and Upward J. Clin. Oncol. 2008, 26, 2-2 10.1200/JCO.2007.14.5144
2. Villanueva, M. T. Imaging in Oncology: Lighting the Way Nat. Rev. Clin. Oncol. 2012, 9, 667 10.1038/nrclinonc.2012.208
3. Butof, R.; Baumann, M. Time in Radiation Oncology-Keep it Short! Radiother. Oncol. 2013, 106, 271-275 10.1016/j.radonc.2013.03.007
4. 2 Nanoflakes for Cancer Theranostics ACS Nano 2015, 9, 11090-11101 10.1021/acsnano.5b04606
5. 3 Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermoradiotherapy Adv. Mater. 2015, 27, 6110-6117 10.1002/adma.201503006
6. Choi, H. S.; Liu, W.; Liu, F.; Nasr, K.; Misra, P.; Bawendi, M. G.; Frangioni, J. V. Design Considerations for Tumour-Targeted Nanoparticles Nat. Nanotechnol. 2010, 5, 42-47 10.1038/nnano.2009.314
7. Lee, D.-E.; Koo, H.; Sun, I.-C.; Ryu, J. H.; Kim, K.; Kwon, I. C. Multifunctional Nanoparticles for Multimodal Imaging and Theragnosis Chem. Soc. Rev. 2012, 41, 2656-2672 10.1039/C2CS15261D
8. Kukowska-Latallo, J. F.; Candido, K. A.; Cao, Z.; Nigavekar, S. S.; Majoros, I. J.; Thomas, T. P.; Balogh, l. P.; Khan, M. K.; Baker-Jr, J. R. Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer Cancer Res. 2005, 65, 5317-5324 10.1158/0008-5472.CAN-04-3921
9. Xing, H.; Zheng, X.; Ren, Q.; Bu, W.; Ge, W.; Xiao, Q.; Zhang, S.; Wei, C.; Qu, H.; Wang, Z.; Hua, Y.; Zhou, L.; Peng, W.; Zhao, K.; Shi, J. Computed Tomography Imaging-Guided Radiotherapy by Targeting Upconversion Nanocubes with Significant Imaging and Radiosensitization Enhancements Sci. Rep. 2013, 3, 1751 10.1038/srep01751
10. Xiao, Q.; Zheng, X.; Bu, W.; Ge, W.; Zhang, S.; Chen, F.; Xing, H.; Ren, Q.; Fan, W.; Zhao, K.; Hua, Y.; Shi, J. A Core/Satellite Multifunctional Nanotheranostic for in Vivo Imaging and Tumor Eradication by Radiation/Photothermal Synergistic Therapy J. Am. Chem. Soc. 2013, 135, 13041-13048 10.1021/ja404985w
11. Jakhmola, A.; Anton, N.; Vandamme, T. F. Inorganic Nanoparticles Based Contrast Agents for X-Ray Computed Tomography Adv. Healthcare Mater. 2012, 1, 413-431 10.1002/adhm.201200032
12. Peng, C.; Zheng, L.; Chen, Q.; Shen, M.; Guo, R.; Wang, H.; Cao, X.; Zhang, G.; Shi, X. Pegylated Dendrimer-Entrapped Gold Nanoparticles for in Vivo Blood Pool and Tumor Imaging by Computed Tomography Biomaterials 2012, 33, 1107-1119 10.1016/j.biomaterials.2011.10.052
13. Deng, H.; Zhong, Y.; Du, M.; Liu, Q.; Fan, Z.; Dai, F.; Zhang, X. Theranostic Self-Assembly Structure of Gold Nanoparticles for NIR Photothermal Therapy and X-Ray Computed Tomography Imaging Theranostics 2014, 4, 904-918 10.7150/thno.9448
14. Hainfeld, J. F.; Smilowitz, H. M.; O'Connor, M. J.; Dilmanian, F. A.; Slatkin, D. N. Gold Nanoparticle Imaging and Radiotherapy of Brain Tumors in Mice Nanomedicine 2013, 8, 1601-1609 10.2217/nnm.12.165
15. Liu, H.; Wang, H.; Xu, Y.; Shen, M.; Zhao, J.; Zhang, G.; Shi, X. Synthesis of Pegylated Low Generation Dendrimer-Entrapped Gold Nanoparticles for CT Imaging Applications Nanoscale 2014, 6, 4521-4526 10.1039/c3nr06694k
16. Wen, S.; Li, K.; Cai, H.; Chen, Q.; Shen, M.; Huang, Y.; Peng, C.; Hou, W.; Zhu, M.; Zhang, G.; Shi, X. Multifunctional Dendrimer-Entrapped Gold Nanoparticles for Dual Mode CT/MR Imaging Applications Biomaterials 2013, 34, 1570-1580 10.1016/j.biomaterials.2012.11.010
17. Zhang, X.-D.; Chen, J.; Luo, Z.; Wu, D.; Shen, X.; Song, S.-S.; Sun, Y.-M.; Liu, P.-X.; Zhao, J.; Huo, S.; Fan, S.; Fan, F.; Liang, X.-J.; Xie, J. Enhanced Tumor Accumulation of Sub- 2nm Gold Nanoclusters for Cancer Radiation Therapy Adv. Healthcare Mater. 2014, 3, 133-141 10.1002/adhm.201300189
18. Huang, P.; Bao, L.; Zhang, C.; Lin, J.; Luo, T.; Yang, D.; He, M.; Li, Z.; Gao, G.; Gao, B.; Fu, S.; Cui, D. Folic Acid-Conjugated Silica-Modified Gold Nanorods for X-Ray/CT Imaging-Guided Dual-Mode Radiation and Photo-Thermal Therapy Biomaterials 2011, 32, 9796-809 10.1016/j.biomaterials.2011.08.086
19. Jeong, S. Y.; Park, S. J.; Yoon, S. M.; Jung, J.; Woo, H. N.; Yi, S. L.; Song, S. Y.; Park, H. J.; Kim, C.; Lee, J. S.; Choi, E. K. Systemic Delivery and Preclinical Evaluation of Au Nanoparticle Containing Beta-Lapachone for Radiosensitization J. Controlled Release 2009, 139, 239-245 10.1016/j.jconrel.2009.07.007
20. Lee, N.; Choi, S. H.; Hyeon, T. Nano-Sized CT Contrast Agents Adv. Mater. 2013, 25, 2641-2660 10.1002/adma.201300081
21. von Maltzahn, G.; Park, J. H.; Agrawal, A.; Bandaru, N. K.; Das, S. K.; Sailor, M. J.; Bhatia, S. N. Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas Cancer Res. 2009, 69, 3892-3900 10.1158/0008-5472.CAN-08-4242
22. Xu, C.; Tung, G. A.; Sun, S. Size and Concentration Effect of Gold Nanoparticles on X-ray Attenuation as Measured on Computed Tomography Chem. Mater. 2008, 20, 4167-4169 10.1021/cm8008418
23. Zhang, X. D.; Wu, D.; Shen, X.; Chen, J.; Sun, Y. M.; Liu, P. X.; Liang, X. J. Size-Dependent Radiosensitization of PEG-Coated Gold Nanoparticles for Cancer Radiation Therapy Biomaterials 2012, 33, 6408-6419 10.1016/j.biomaterials.2012.05.047
24. Jones, C. F.; Grainger, D. W. In Vitro Assessments of Nanomaterial Toxicity Adv. Drug Delivery Rev. 2009, 61, 438-456 10.1016/j.addr.2009.03.005
25. Brannon-Peppas, L.; Blanchette, J. O. Nanoparticle and Targeted Systems for Cancer Therapy Adv. Drug Delivery Rev. 2012, 64, 206-212 10.1016/j.addr.2012.09.033
26. Suh, W. H.; Suslick, K. S.; Stucky, G. D.; Suh, Y. H. Nanotechnology, Nanotoxicology, and Neuroscience Prog. Neurobiol. 2009, 87, 133-170 10.1016/j.pneurobio.2008.09.009
27. McMahon, S. J.; Hyland, W. B.; Muir, M. F.; Coulter, J. A.; Jain, S.; Butterworth, K. T.; Schettino, G.; Dickson, G. R.; Hounsell, A. R.; O'Sullivan, J. M.; Prise, K. M.; Hirst, D. G.; Currrell, F. J. Biological Consequences of Nanoscale Energy Deposition Near Irradiated Heavy Atom Nanoparticles Sci. Rep. 2011, 1, 18 10.1038/srep00018
28. Jeynes, J. C.; Merchant, M. J.; Spindler, A.; Wera, A. C.; Kirkby, K. J. Investigation of Gold Nanoparticle Radiosensitisation Mechanisms Using a Free Radical Scavenger and Protons of Different Energies Phys. Med. Biol. 2014, 59, 6431-6443 10.1088/0031-9155/59/21/6431
29. Metropolis, N.; Ulam, S. The Monte Carlo Method J. Am. Stat. Assoc. 1949, 44, 335-341 10.1080/01621459.1949.10483310
30. Douglass, M.; Bezak, E.; Penfold, S. Monte Carlo Investigation of the Increased Radiation Deposition Due to Gold Nanoparticles Using Kilovoltage and Megavoltage Photons in a 3D Randomized Cell Model Med. Phys. 2013, 40, 071710 10.1118/1.4808150
31. Leung, M. K. K.; Chow, J. C. L.; Chithrani, B. D.; Lee, M. J. G.; Oms, B.; Jaffray, D. A. Irradiation of Gold Nanoparticles by X-Rays: Monte Carlo Simulation of Dose Enhancements and the Spatial Properties of the Secondary Electrons Production Med. Phys. 2011, 38, 624-631 10.1118/1.3539623
32. Yu, S. B.; Watson, A. D. Metal-Based X-ray Contrast Media Chem. Rev. 1999, 99, 2353-2378 10.1021/cr980441p
33. Lusic, H.; Grinstaff, M. W. X-Ray-Computed Tomography Contrast Agents Chem. Rev. 2013, 113, 1641-1666 10.1021/cr200358s
34. Nilsson, B. Electron Contamination from Different Materials in High Energy Photon Beams Phys. Med. Biol. 1985, 30, 139-151 10.1088/0031-9155/30/2/003
35. Biggs, P. J.; Russell, M. D. An Investigation into the Presence of Secondary Electrons in Megavoltage Photon Beams Phys. Med. Biol. 1983, 28, 1033-1043 10.1088/0031-9155/28/9/003
36. Lin, Y.; McMahon, S. J.; Scarpelli, M.; Paganetti, H.; Schuemann, J. Comparing Gold Nano-Particle Enhanced Radiotherapy with Protons, Megavoltage Photons and Kilovoltage Photons: A Monte Carlo Simulation Phys. Med. Biol. 2014, 59, 7675-7689 10.1088/0031-9155/59/24/7675
37. Keall, P.; Monti di Sopra, F.; Beckham, W.; Delaney, G. Comparison of Kilovoltage X-Ray and Electron Beam Dose Distributions for Radiotherapy of The Sternum Med. Dosim. 1999, 24, 141-144 10.1016/S0958-3947(99)00004-7
38. Robar, J. L. Generation and Modelling of Megavoltage Photon Beams for Contrast-Enhanced Radiation Therapy Phys. Med. Biol. 2006, 51, 5487-5504 10.1088/0031-9155/51/21/007
39. Yu, M.; Zheng, J. Clearance Pathways and Tumor Targeting of Imaging Nanoparticles ACS Nano 2015, 9, 6655-6674 10.1021/acsnano.5b01320
40. Zhang, X. D.; Wu, D.; Shen, X.; Liu, P. X.; Fan, F. Y.; Fan, S. J. In Vivo Renal Clearance, Biodistribution, Toxicity of Gold Nanoclusters Biomaterials 2012, 33, 4628-4638 10.1016/j.biomaterials.2012.03.020
41. Cho, W.-S.; Cho, M.; Jeong, J.; Choi, M.; Han, B. S.; Shin, H.-S.; Hong, J.; Chung, B. H.; Jeong, J.; Cho, M.-H. Size-Dependent Tissue Kinetics of PEG-Coated Gold Nanoparticles Toxicol. Appl. Pharmacol. 2010, 245, 116-123 10.1016/j.taap.2010.02.013
42. Cho, E. C.; Zhang, Q.; Xia, Y. The Effect of Sedimentation and Diffusion on Cellular Uptake of Gold Nanoparticles Nat. Nanotechnol. 2011, 6, 385-391 10.1038/nnano.2011.58
43. Mout, R.; Moyano, D. F.; Rana, S.; Rotello, V. M. Surface Functionalization of Nanoparticles for Nanomedicine Chem. Soc. Rev. 2012, 41, 2539-2544 10.1039/c2cs15294k
44. Khlebtsov, N.; Dykman, L. Biodistribution and Toxicity of Engineered Gold Nanoparticles: A Review of in Vitro and in Vivo Studies Chem. Soc. Rev. 2011, 40, 1647-1671 10.1039/C0CS00018C
45. Weintraub, K. Biomedicine: The New Gold Standard Nature 2013, 495, 128-129 10.1038/495S14a
46. Pelegri-O'Day, E. M.; Lin, E. W.; Maynard, H. D. Therapeutic Protein-Polymer Conjugates: Advancing beyond Pegylation J. Am. Chem. Soc. 2014, 136, 14323-14332 10.1021/ja504390x
47. Delgado, C.; Francis, G. E.; Fisher, D. The Uses and Properties of PEG-Linked Proteins Crit. Rev. Ther. Drug. 1992, 9, 249-304
48. Bastús, N. G.; Comenge, J.; Puntes, V. Kinetically Controlled Seeded Growth Synthesis of Citrate-Stabilized Gold Nanoparticles of Up to 200 nm: Size Focusing Versus Ostwald Ripening Langmuir 2011, 27, 11098-11105 10.1021/la201938u
49. Jana, N. R.; Gearheart, L.; Murphy, C. J. Seeding Growth for Size Control of 5-40 nm Diameter Gold Nanoparticles Langmuir 2001, 17, 6782-6786 10.1021/la0104323
50. Kawrakow, I. Accurate Condensed History Monte Carlo Simulation of Electron Transport. I. Egsnrc, the New EGS4 Version Med. Phys. 2000, 27, 485-498 10.1118/1.598917
51. Botta, F.; Mairani, A.; Hobbs, R. F.; Gil, A. V.; Pacilio, M.; Parodi, K. Use of the FLUKA Monte Carlo Code for 3D Patient-Specific Dosimetry on PET-CT and SPECT-CT Images Phys. Med. Biol. 2013, 58, 8099-8120 10.1088/0031-9155/58/22/8099
52. Weng, X.; Yan, Y.; Shu, H.; Wang, J.; Jiang, S. B.; Luo, L. A Vectorized Monte Carlo Code for Radiotherapy Treatment Planning Dose Calculation Phys. Med. Biol. 2003, 48, N111-N120 10.1088/0031-9155/48/7/401