Inactivation of the orbitofrontal cortex reduces irrational choice on a rodent Betting Task

Neuroscience

Volumn 345, Issue , 2017, Pages 38-48

  Barrus, M M ^a   Hosking, J G ^b   Cocker, P J ^a   Winstanley, C A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b HARVARD UNIVERSITY   (United States)

Author keywords

baclofen muscimol; decision making; gambling; impulsivity; infralimbic; prelimbic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOICE PATTERN CHARACTERISTIC; CONTROLLED STUDY; DECISION MAKING; GAMBLING; INFRALIMBIC CORTEX; MALE; NONHUMAN; ORBITAL CORTEX; PRELIMBIC CORTEX; RAT; RISK ASSESSMENT; RODENT; RODENT BETTING TASK; SUNK COST EFFECT; UNCERTAINTY; ANIMAL; DRUG EFFECTS; LIMBIC CORTEX; LONG EVANS RAT; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PREFRONTAL CORTEX;

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; MUSCIMOL;

ANIMALS; BACLOFEN; CHOICE BEHAVIOR; GABA-A RECEPTOR AGONISTS; GABA-B RECEPTOR AGONISTS; GAMBLING; JUDGMENT; LIMBIC LOBE; MALE; MUSCIMOL; NEUROPSYCHOLOGICAL TESTS; PREFRONTAL CORTEX; RATS, LONG-EVANS;

EID: 84960155597     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2016.02.028     Document Type: Article

References (62)

1. Bajtelsmit VL, VanDerhei JL (1997) Risk aversion and pension investment choices. In: Positioning pensions for the twenty-first century, pp 45–66.
2. Baker, P.M., Ragozzino, M.E., The prelimbic cortex and subthalamic nucleus contribute to cue-guided behavioral switching. Neurobiol Learn Mem 107 (2014), 65–78.
3. Balleine, B.W., Dickinson, A., Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37 (1998), 407–419.
4. Barrus, M.M., Hosking, J.G., Zeeb, F.D., Tremblay, M., Winstanley, C.A., Disadvantageous decision-making is associated with increased motor impulsivity at the population level on a rodent gambling task. J Psychiatry Neurosci 40 (2015), 108–117.
5. Berendse, H.W., Galisdegraaf, Y., Groenewegen, H.J., Topographical organisation and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol 316 (1992), 314–347.
6. Birrell, J.M., Brown, V.J., Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20 (2000), 4320–4324.
7. Buchanan, S.L., Thompson, R.H., Maxwell, B.L., Powell, D.A., Efferent connections of the medial prefrontal cortex in the rabbit. Exp Brain Res 100 (1994), 469–483.
8. Cardinal, R.N., Robbins, T.W., Everitt, B.J., The effects of d-amphetamine, chlordiazepoxide, alpha-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats. Psychopharmacology 152 (2000), 362–375.
9. Cardinal, R.N., Pennicott, D.R., Sugathapala, C.L., Robbins, T.W., Everitt, B.J., Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292 (2001), 2499–2501.
10. Chudasama, Y., Passetti, F., Rhodes, S.E.V., Lopian, D., Desai, A., Robbins, T.W., Dissociable aspects of performance on the 5 choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res 146 (2003), 105–119.
11. Clark, L., Decision-making during gambling: an integration of cognitive and psychobiological approaches. Philos Trans R Soc Lond B Biol Sci 365 (2010), 319–330.
12. Clark, L., Studer, B., Bruss, J., Tranel, D., Bechara, A., Damage to insula abolishes cognitive distortions during simulated gambling. Proc Natl Acad Sci U S A 111 (2014), 6098–6103.
13. Cocker, P.J., Dinelle, K., Kornelson, R., Sossi, V., Winstanley, C.A., Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats. J Neurosci 32 (2012), 15450–15457.
14. Crean, J., Richards, J.B., de Wit, H., Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. Behav Brain Res 136 (2002), 349–357.
15. Dalley, J.W., Cardinal, R.N., Robbins, T.W., Prefrontal executive and cognitive function in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28 (2004), 771–784.
16. Dalley, J.W., Fryer, T.D., Brichard, L., Robinson, E.S., Theobald, D.E., Laane, K., Pena, Y., Murphy, E.R., Shah, Y., Probst, K., Abakumova, I., Aigbirhio, F.I., Richards, H.K., Hong, Y., Baron, J.C., Everitt, B.J., Robbins, T.W., Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315 (2007), 1267–1270.
17. Damasio, A.R., Descartes’ error. 1994, Putman, New York.
18. de Wit, H., Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol 14 (2009), 22–31.
19. Floresco, S.B., Ghods-Sharifi, S., Vexelman, C., Magyar, O., Dissociable roles for the nucleus accumbens core and shell in regulating set shifting. J Neurosci 26 (2006), 2449–2457.
20. Granon, S., Vidal, C., Thinus-Blanc, C., Changeux, J.P., Poucet, B., Working memory, response selection, and effortful processing in rats with medial prefrontal lesions. Behav Neurosci 108 (1994), 883–891.
21. Hosking, J.G., Cocker, P.J., Winstanley, C.A., Prefrontal cortical inactivations decrease willingness to expend cognitive effort on a rodent cost/benefit decision-making task. Cereb Cortex, 2015.
22. Killcross, S., Coutureau, E., Coordination of actions and habits in the medial prefrontal cortex of rats. Cereb Cortex 13 (2003), 400–408.
23. Kringelbach, M.L., The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci 6 (2005), 691–702.
24. Kringelbach, M.L., O'Doherty, J., Rolls, E.T., Andrews, C., Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness. Cereb Cortex 13 (2003), 1064–1071.
25. Lesieur, H.R., Blume, S.B., The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am J Psychiatry 144 (1987), 1184–1188.
26. Lucantonio, F., Takahashi, Y.K., Hoffman, A.F., Chang, C.Y., Bali-Chaudhary, S., Shaham, Y., Lupica, C.R., Schoenbaum, G., Orbitofrontal activation restores insight lost after cocaine use. Nat Neurosci 17 (2014), 1092–1099.
27. McDannald, M.A., Jones, J.L., Takahashi, Y.K., Schoenbaum, G., Learning theory: a driving force in understanding orbitofrontal function. Neurobiol Learn Mem 108 (2014), 22–27.
28. Michalczuk, R., Bowden-Jones, H., Verdejo-Garcia, A., Clark, L., Impulsivity and cognitive distortions in pathological gamblers attending the UK National Problem Gambling Clinic: a preliminary report. Psychol Med, 2011, 1–11.
29. Mitchell, J.M., Fields, H.L., D'Esposito, M., et al. Impulsive responding in alcoholics. Alcohol Clin Exp Res 29 (2005), 2158–2169.
30. Muir, J.L., Everitt, B.J., Robbins, T.W., The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb Cortex 6 (1996), 470–481.
31. Naqvi, N.H., Rudrauf, D., Damasio, H., Bechara, A., Damage to the insula disrupts addiction to cigarette smoking. Science 315 (2007), 531–534.
32. Paine, T.A., Asinof, S.K., Diehl, G.W., Frackman, A., Leffler, J., Medial prefrontal cortex lesions impair decision-making on a rodent gambling task: reversal by D1 receptor antagonist administration. Behav Brain Res 243 (2013), 247–254.
33. Paxinos, G., Watson, C., The rat brain in stereotaxic co-ordinates. fourth ed., 1998, Academic Press, Sydney.
34. Peters, J., LaLumiere, R.T., Kalivas, P.W., Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats. J Neurosci 28 (2008), 6046–6053.
35. Pushparaj, A., Hamani, C., Yu, W., Shin, D.S., Kang, B., Nobrega, J.N., Le Foll, B., Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors. Neuropsychopharmacology 38 (2012), 690–698.
36. Pushparaj, A., Kim, A.S., Musiol, M., Zangen, A., Daskalakis, Z.J., Zack, M., Winstanley, C.A., Le Foll, B., Differential involvement of the agranular vs granular insular cortex in the acquisition and performance of choice behavior in a rodent gambling task. Neuropsychopharmacology, 2015.
37. Quirk, G.J., Garcia, R., Gonzalez-Lima, F., Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry 60 (2006), 337–343.
38. Raylu, N., Oei, T.P., The Gambling Related Cognitions Scale (GRCS): development, confirmatory factor validation and psychometric properties. Addiction 99 (2004), 757–769.
39. Rolls, E.T., The orbitofrontal cortex and reward. Cereb Cortex 10 (2000), 284–294.
40. Rolls, E.T., Brain mechanisms underlying flavour and appetite. Philos Trans R Soc Lond B Biol Sci 361 (2006), 1123–1136.
41. Schilman, E.A., Uylings, H.B., Galis-de Graaf, Y., Joel, D., Groenewegen, H.J., The orbital cortex in rats topographically projects to central parts of the caudate–putamen complex. Neurosci Lett 432 (2008), 40–45.
42. Schoenbaum, G., Chiba, A.A., Gallagher, M., Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning. Nat Neurosci 1 (1998), 155–159.
43. Schoenbaum, G., Chiba, A.A., Gallagher, M., Neural encoding in orbitofrontal cortex and basolateral amygdala during olfactory discrimination learning. J Neurosci 19 (1999), 1876–1884.
44. Seaman, J.K., Floresco, S.B., Phillips, A.G., Functional differences between the prelimbic and anterior cingulate regions of the rat prefrontal cortex. Behav Neurosci 109:6 (1995), 1063–1073.
45. Shiv, B., Loewenstein, G., Bechara, A., The dark side of emotion in decision-making: when individuals with decreased emotional reactions make more advantageous decisions. Brain Res Cogn Brain Res 23 (2005), 85–92.
46. Shiv, B., Loewenstein, G., Bechara, A., Damasio, H., Damasio, A.R., Investment behavior and the negative side of emotion. Psychol Sci 16 (2005), 435–439.
47. Specker, S.M., Carlson, G.A., Christenson, G.A., Marcotte, M., Impulse control disorders and attention deficit disorder in pathological gamblers. Ann Clin Psychiatry 7:4 (1995), 175–179.
48. St Onge, J.R., Floresco, S.B., Prefrontal cortical contribution to risk-based decision making. Cereb Cortex 20 (2010), 1816–1828.
49. Stalnaker, T.A., Cooch, N.K., Schoenbaum, G., What the orbitofrontal cortex does not do. Nat Neurosci 18 (2015), 620–627.
50. Steenbergh, T.A., Meyers, A.W., May, R.K., Whelan, J.P., Development and validation of the gamblers’ beliefs questionnaire. Psychol Addict Behav 16 (2002), 143–149.
51. Takagishi, M., Chiba, T., Efferent projections of the infralimbic (area 25) region of the medial prefrontal cortex in the rat: an anterograde tracer PHA-L study. Brain Res 566 (1991), 26–39.
52. Toneatto, T., Blitz-Miller, T., Calderwood, K., Dragonetti, R., Tsanos, A., Cognitive distortions in heavy gambling. J Gambl Stud 13:3 (1997), 253–266.
53. Tremblay, M., Cocker, P.J., Hosking, J.G., Zeeb, F.D., Rogers, R.D., Winstanley, C.A., Dissociable effects of basolateral amygdala lesions on decision-making biases in rats when loss or gain is emphasized. Cogn Affect Behav Neurosci 14 (2014), 1184–1195.
54. Tversky, A., Kahneman, D., Judgment under uncertainty: heuristics and biases. Science 185:4157 (1974), 1124–1131.
55. Verdejo-Garcia, A., Lawrence, A.J., Clark, L., Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies. Neurosci Biobehav Rev 32:4 (2008), 777–810.
56. Vertes, R.P., Differential projections of the infralimbic and prelimbic cortex in the rat. Synapse 51:1 (2004), 32–58.
57. Winstanley, C.A., The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders. Br J Pharmacol 164 (2011), 1301–1321.
58. Winstanley, C.A., Chudasama, Y., Dalley, J.W., Theobald, D.E., Glennon, J.C., Robbins, T.W., Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats. Psychopharmacology (Berl) 167:3 (2003), 304–314.
59. Winstanley, C.A., Theobald, D.E.H., Cardinal, R.N., Robbins, T.W., Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J Neurosci 24 (2004), 4718–4722.
60. Winstanley, C.A., Theobald, D.E., Dalley, J.W., Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology 29 (2004), 1331–1343.
61. Zeeb, F.D., Floresco, S.B., Winstanley, C.A., Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues. Psychopharmacology (Berl) 211 (2010), 87–98.
62. Zeeb, F.D., Baarendse, P.J., Vanderschuren, L.J.M., Winstanley, C.A., Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task. Psychopharmacology (Berl) 24 (2015), 4481–4491.