-
1
-
-
84902449207
-
Targeting receptor tyrosine kinase MET in cancer:small molecule inhibitors and clinical progress
-
Cui JJ. Targeting receptor tyrosine kinase MET in cancer:small molecule inhibitors and clinical progress. J Med Chem 2014;57:4427-53.
-
(2014)
J Med Chem
, vol.57
, pp. 4427-4453
-
-
Cui, J.J.1
-
2
-
-
79955458487
-
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification
-
Ou SH, Kwak EL, Siwak-Tapp C, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification. J Thorac Oncol 2011;6:942-6.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 942-946
-
-
Ou, S.H.1
Kwak, E.L.2
Siwak-Tapp, C.3
-
3
-
-
84902811306
-
Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC)
-
Camidge DR, Ou SH, Shapiro G, et al. Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC). J Clin Oncol 2014;32:abstr 8001.
-
(2014)
J Clin Oncol
, vol.32
, pp. 8001
-
-
Camidge, D.R.1
Ou, S.H.2
Shapiro, G.3
-
4
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
75ra26
-
Sequist LV, Waltman BA, Dias-Santagata D, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011;3:75ra26.
-
(2011)
Sci Transl Med
, vol.3
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
5
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 2013;19:2240-7.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
6
-
-
84878570861
-
Phase I/II dosefinding study of crizotinib (CRIZ) in combination with erlotinib (E) in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
Ou SH, Govindan R, Eaton KD, et al. Phase I/II dosefinding study of crizotinib (CRIZ) in combination with erlotinib (E) in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2012;30:abstr 2610.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2610
-
-
Ou, S.H.1
Govindan, R.2
Eaton, K.D.3
-
7
-
-
84943737027
-
A randomized, double-blind, placebo-controlled, phase III trial of erlotinib with or without a c-Met inhibitor tivantinib (ARQ 197) in Asian patients with previously treated stage IIIB/IV nonsquamous nonsmall-cell lung cancer harboring wildtype epidermal growth factor receptor (ATTENTION study)
-
Yoshioka H, Azuma K, Yamamoto N, et al. A randomized, double-blind, placebo-controlled, phase III trial of erlotinib with or without a c-Met inhibitor tivantinib (ARQ 197) in Asian patients with previously treated stage IIIB/IV nonsquamous nonsmall-cell lung cancer harboring wildtype epidermal growth factor receptor (ATTENTION study). Ann Oncol 2015;26:2066-72.
-
(2015)
Ann Oncol
, vol.26
, pp. 2066-2072
-
-
Yoshioka, H.1
Azuma, K.2
Yamamoto, N.3
-
8
-
-
84940394869
-
Phase III multinational, randomized, double-blind, placebocontrolled study of tivantinib (ARQ 197) Plus erlotinib versus erlotinib alone in previously treated patients with locally advanced or metastatic nonsquamous non-smallcell lung cancer
-
Scagliotti G, von Pawel J, Novello S, et al. Phase III multinational, randomized, double-blind, placebocontrolled study of tivantinib (ARQ 197) Plus erlotinib versus erlotinib alone in previously treated patients with locally advanced or metastatic nonsquamous non-smallcell lung cancer. J Clin Oncol 2015;33:2667-74.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2667-2674
-
-
Scagliotti, G.1
von Pawel, J.2
Novello, S.3
-
9
-
-
84922373207
-
The landscape of kinase fusions in cancer
-
Stransky N, Cerami E, Schalm S, et al. The landscape of kinase fusions in cancer. Nat Commun 2014;5:4846.
-
(2014)
Nat Commun
, vol.5
, pp. 4846
-
-
Stransky, N.1
Cerami, E.2
Schalm, S.3
-
10
-
-
0141988690
-
c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions
-
Ma PC, Kijima T, Maulik G, et al. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res 2003;63:6272-81.
-
(2003)
Cancer Res
, vol.63
, pp. 6272-6281
-
-
Ma, P.C.1
Kijima, T.2
Maulik, G.3
-
11
-
-
13944276728
-
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
-
Ma PC, Jagadeeswaran R, Jagadeesh S, et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 2005;65:1479-88.
-
(2005)
Cancer Res
, vol.65
, pp. 1479-1488
-
-
Ma, P.C.1
Jagadeeswaran, R.2
Jagadeesh, S.3
-
12
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 2006;66:283-9.
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
-
13
-
-
27144512084
-
Met/ Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
-
Abella JV, Peschard P, Naujokas MA, et al. Met/ Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol 2005;25:9632-45.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9632-9645
-
-
Abella, J.V.1
Peschard, P.2
Naujokas, M.A.3
-
14
-
-
84868309107
-
The transcriptional landscape and mutational profile of lung adenocarcinoma
-
Seo JS, Ju YS, Lee WC, et al. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res 2012;22:2109-19.
-
(2012)
Genome Res
, vol.22
, pp. 2109-2119
-
-
Seo, J.S.1
Ju, Y.S.2
Lee, W.C.3
-
15
-
-
84905029258
-
Comprehensive molecular profiling of lung adenocarcinoma
-
Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014;511:543-50.
-
(2014)
Nature
, vol.511
, pp. 543-550
-
-
-
16
-
-
84938815085
-
Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
-
Paik PK, Drilon A, Fan PD, et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov 2015;5:842-9.
-
(2015)
Cancer Discov
, vol.5
, pp. 842-849
-
-
Paik, P.K.1
Drilon, A.2
Fan, P.D.3
-
17
-
-
84938805958
-
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
-
Frampton GM, Ali SM, Rosenzweig M, et al. Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov 2015;5:850-9.
-
(2015)
Cancer Discov
, vol.5
, pp. 850-859
-
-
Frampton, G.M.1
Ali, S.M.2
Rosenzweig, M.3
-
18
-
-
84947874927
-
Next-Generation sequencing of pulmonary sarcomatoid carcinoma reveals high frequency of actionable MET gene mutations
-
Epub ahead of print
-
Liu X, Jia Y, Stoopler MB, et al. Next-Generation sequencing of pulmonary sarcomatoid carcinoma reveals high frequency of actionable MET gene mutations. J Clin Oncol 2015. [Epub ahead of print].
-
(2015)
J Clin Oncol
-
-
Liu, X.1
Jia, Y.2
Stoopler, M.B.3
-
19
-
-
84941420654
-
Response to crizotinib in a patient with lung adenocarcinoma harboring a MET splice site mutation
-
Jenkins RW, Oxnard GR, Elkin S, et al. Response to crizotinib in a patient with lung adenocarcinoma harboring a MET splice site mutation. Clin Lung Cancer 2015;16:e101-4.
-
(2015)
Clin Lung Cancer
, vol.16
, pp. e101-e104
-
-
Jenkins, R.W.1
Oxnard, G.R.2
Elkin, S.3
-
20
-
-
84938222817
-
MET Mutation Associated with Responsiveness to Crizotinib
-
Waqar SN, Morgensztern D, Sehn J. MET Mutation Associated with Responsiveness to Crizotinib. J Thorac Oncol 2015;10:e29-31.
-
(2015)
J Thorac Oncol
, vol.10
, pp. e29-31
-
-
Waqar, S.N.1
Morgensztern, D.2
Sehn, J.3
-
21
-
-
84938227821
-
MET-mutated NSCLC with major response to crizotinib
-
Mendenhall MA, Goldman JW. MET-mutated NSCLC with major response to crizotinib. J Thorac Oncol 2015;10:e33-4.
-
(2015)
J Thorac Oncol
, vol.10
, pp. e33-e34
-
-
Mendenhall, M.A.1
Goldman, J.W.2
-
22
-
-
84947942831
-
MET 14 deletion in sarcomatoid non-small-cell lung cancer detected by next-generation sequencing and successfully treated with a MET inhibitor
-
Lee C, Usenko D, Frampton GM, et al. MET 14 deletion in sarcomatoid non-small-cell lung cancer detected by next-generation sequencing and successfully treated with a MET inhibitor. J Thorac Oncol 2015;10:e113-4.
-
(2015)
J Thorac Oncol
, vol.10
, pp. e113-e114
-
-
Lee, C.1
Usenko, D.2
Frampton, G.M.3
-
23
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
24
-
-
84911372597
-
Crizotinib in ROS1- rearranged non-small-cell lung cancer
-
Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1- rearranged non-small-cell lung cancer. N Engl J Med 2014;371:1963-71.
-
(2014)
N Engl J Med
, vol.371
, pp. 1963-1971
-
-
Shaw, A.T.1
Ou, S.H.2
Bang, Y.J.3
-
25
-
-
84944474562
-
Gastrointestinal malignancies harbor actionable METex14s
-
Lee J, Ou SH, Lee JM, et al. Gastrointestinal malignancies harbor actionable METex14s. Oncotarget 2015;6:28211-22.
-
(2015)
Oncotarget
, vol.6
, pp. 28211-28222
-
-
Lee, J.1
Ou, S.H.2
Lee, J.M.3
|