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Volumn 34, Issue 1, 2016, Pages 55-57

Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis

Author keywords

[No Author keywords available]

Indexed keywords

BLINATUMOMAB; CYCLOPHOSPHAMIDE; FERRITIN; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; METHYLPREDNISOLONE; TOCILIZUMAB; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GRANZYME; MONOCLONAL ANTIBODY;

EID: 84960121323     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.2174     Document Type: Letter
Times cited : (17)

References (10)
  • 2
    • 17744414197 scopus 로고    scopus 로고
    • Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis
    • Osugi Y, Hara J, Tagawa S, et al. Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood 1997; 89: 4100-4103.
    • (1997) Blood , vol.89 , pp. 4100-4103
    • Osugi, Y.1    Hara, J.2    Tagawa, S.3
  • 3
    • 33845619137 scopus 로고    scopus 로고
    • HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
    • Henter J-I, Horne A, Aricó M, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 2007; 48: 124-131.
    • (2007) Pediatr Blood Cancer , vol.48 , pp. 124-131
    • Henter, J.-I.1    Horne, A.2    Aricó, M.3
  • 4
    • 84861526602 scopus 로고    scopus 로고
    • Diagnostic accuracy of a specific cytokine pattern in hemophagocytic lymphohistiocytosis in children
    • Xu X-J, Tang Y-M, Song H, et al. Diagnostic accuracy of a specific cytokine pattern in hemophagocytic lymphohistiocytosis in children. J Pediatr 2012; 160: 984-90.e1.
    • (2012) J Pediatr , vol.160 , pp. 901-984
    • Xu, X.-J.1    Tang, Y.-M.2    Song, H.3
  • 6
    • 84896495791 scopus 로고    scopus 로고
    • A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy
    • Tanaka T, Narazaki M, Ogata A, Kishimoto T. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin Immunol 2014; 26: 88-96.
    • (2014) Semin Immunol , vol.26 , pp. 88-96
    • Tanaka, T.1    Narazaki, M.2    Ogata, A.3    Kishimoto, T.4
  • 7
    • 84876325876 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
    • Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med 2013; 368: 1509-1518.
    • (2013) N Engl J Med , vol.368 , pp. 1509-1518
    • Grupp, S.A.1    Kalos, M.2    Barrett, D.3
  • 8
    • 84882782587 scopus 로고    scopus 로고
    • Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy
    • Teachey DT, Rheingold SR, Maude SL, et al. Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy. Blood 2013; 121: 5154-5157.
    • (2013) Blood , vol.121 , pp. 5154-5157
    • Teachey, D.T.1    Rheingold, S.R.2    Maude, S.L.3
  • 9
    • 58149154996 scopus 로고    scopus 로고
    • Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
    • Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 2008; 112: 3959-3964.
    • (2008) Blood , vol.112 , pp. 3959-3964
    • Nishimoto, N.1    Terao, K.2    Mima, T.3    Nakahara, H.4    Takagi, N.5    Kakehi, T.6
  • 10
    • 84883781078 scopus 로고    scopus 로고
    • Elevated granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis
    • Mellor-Heineke S, Villanueva J, Jordan MB, et al. Elevated granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis. Front Immunol 2013; 4: 72. doi: 10.3389/fimmu.2013.00072
    • (2013) Front Immunol , vol.4 , pp. 72
    • Mellor-Heineke, S.1    Villanueva, J.2    Jordan, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.