Diagnostic accuracy of a specific cytokine pattern in hemophagocytic lymphohistiocytosis in children

Journal of Pediatrics

Volumn 160, Issue 6, 2012, Pages

  Xu, Xiao Jun ^a   Tang, Yong Min ^a   Song, Hua ^a   Yang, Shi Long ^a   Xu, Wei Qun ^a   Zhao, Ning ^a   Shi, Shu Wen ^a   Shen, He Ping ^a   Mao, Jun Qing ^a   Zhang, Ling Yan ^a   Pan, Bin Hua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

CBA; Cytometric bead array; Fever of unknown origin; FUO; Hemophagocytic lymphohistiocytosis; HLH; IFN ; IL; Interferon gamma; Interleukin; Receiver operating characteristic; ROC; sCD25; Soluble interleukin 2 receptor; TNF ; Tumor necrosis factor alpha

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; FEVER; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HUMAN; INFANT; INFECTION; MAJOR CLINICAL STUDY; MALE; PEDIATRICS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 84861526602     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.11.046     Document Type: Article

References (19)

1. S. Gupta, and S. Weitzman Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy Expert Rev Clin Immunol 6 2010 137 154
2. Y. Tang, and X. Xu Advances in hemophagocytic lymphohistiocytosis: pathogenesis, early diagnosis/differential diagnosis, and treatment TheScientificWorldJo 11 2011 697 708
3. J.I. Henter, A. Horne, M. Arico, R.M. Egeler, A.H. Filipovich, and S. Imashuku HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Pediatr Blood Cancer 48 2007 124 131
4. H.R. Freeman, and A.V. Ramanan Review of haemophagocytic lymphohistiocytosis Arch Dis Child 96 2011 688 693
5. G.E. Janka Familial and acquired hemophagocytic lymphohistiocytosis Eur J Pediatr 166 2007 95 109
6. J.I. Henter, G. Elinder, O. Soder, M. Hansson, B. Andersson, and U. Andersson Hypercytokinemia in familial hemophagocytic lymphohistiocytosis Blood 78 1991 2918 2922
7. Y. Osugi, J. Hara, S. Tagawa, K. Takai, G. Hosoi, and Y. Matsuda Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis Blood 89 1997 4100 4103
8. Y. Tang, X. Xu, H. Song, S. Yang, S. Shi, and J. Wei Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome Br J Haematol 143 2008 84 91
9. Y. Tang, C. Liao, X. Xu, H. Song, S. Shi, and S. Yang Evaluation of Th1/Th2 cytokines as a rapid diagnostic tool for severe infection in paediatric haematology/oncology patients by the use of cytometric bead array technology Clin Microbiol Infect 17 2011 1666 1673
10. Y. Chen, S. Shang, C. Zhang, T. Liu, Z. Yang, and Y. Tang Hemophagocytic lymphohistiocytosis at initiation of Kawasaki disease and their differential diagnosis Pediatr Hematol Oncol 27 2010 244 249
11. L. Castillo, and J. Carcillo Secondary hemophagocytic lymphohistiocytosis and severe sepsis/ systemic inflammatory response syndrome/multiorgan dysfunction syndrome/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation Pediatr Crit Care Med 10 2009 387 392
12. K. Kuwata, S. Yamada, E. Kinuwaki, M. Naito, and H. Mitsuya Peripheral hemophagocytosis: An early indicator of advanced systemic inflammatory response syndrome/hemophagocytic syndrome Shock 25 2006 344 350
13. C. Santana Reyes, F. Garcia-Munoz, D. Reyes, G. Gonzalez, C. Dominguez, and E. Domenech Role of cytokines (interleukin-1beta, 6, 8, tumour necrosis factor-alpha, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis Acta Paediatr 92 2003 221 227
14. C.E. Allen, X. Yu, C.A. Kozinetz, and K.L. McClain Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis Pediatr Blood Cancer 50 2008 1227 1235
15. A. Gaur, E. Morgan, R. Varro, H. Sepulveda, J.A. Ember, and J. Apgar Cytometric bead array: a multiplexed assay platform with applications in various areas of biology Clin Immunol 110 2004 252 266
16. M.F. Elshal, and J.P. McCoy Multiplex bead array assays: performance evaluation and comparison of sensitivity to ELISA Methods 38 2006 317 323
17. S. Ohga, K. Kudo, E. Ishii, S. Honjo, A. Morimoto, and Y. Osugi Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan Pediatr Blood Cancer 54 2010 299 306
18. S. Imashuku, S. Hlbi, and S. Todo Hemophagocytic lymphohistiocytosis in infancy and childhood J Pediatr 130 1997 352 357
19. S. Imashuku, S. Hibi, M. Sako, Y. Ishida, H. Mugishima, and J. Chen Soluble interleukin-2 receptor: a useful prognostic factor for patients with hemophagocytic lymphohistiocytosis Blood 86 1995 4706 4707