Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems

European Polymer Journal

Volumn 78, Issue , 2016, Pages 14-24

  Cuggino, Julio César ^a   Molina, Maria ^b   Wedepohl, Stefanie ^b   Igarzabal, Cecilia Inés Alvarez ^c   Calderón, Marcelo ^b   Gugliotta, Luis Marcelino ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Cancer; Doxorubicin; Drug delivery; Ionic complexes; Nanogels; Nanomedicine; NIPA co AAc; pH triggered

Indexed keywords

ACRYLIC MONOMERS; DISEASES; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; LIGHT SCATTERING; MEDICAL NANOTECHNOLOGY; MOLECULAR BIOLOGY; NANOSTRUCTURED MATERIALS; ONCOLOGY; POLYETHYLENES;

CANCER; DOXORUBICIN; IONIC COMPLEX; NANOGELS; NIPA-CO-AAC;

DRUG THERAPY;

EID: 84960110263     PISSN: 00143057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eurpolymj.2016.02.022     Document Type: Article

References (30)

1. R. Gref, A. Domb, P. Quellec, T. Blunk, R.H. Müller, J.M. Verbavatz, and et al. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres Adv. Drug Delivery Rev. 64 Supplement(0) 2012 316 326
2. J.K. Oh, R. Drumright, D.J. Siegwart, and K. Matyjaszewski The development of microgels/nanogels for drug delivery applications Prog. Polym. Sci. 33 4 2008 448 477
3. R.T. Chacko, J. Ventura, J. Zhuang, and S. Thayumanavan Polymer nanogels: A versatile nanoscopic drug delivery platform Adv. Drug Delivery Rev. 64 9 2012 836 851
4. M. Elsabahy, and K.L. Wooley Design of polymeric nanoparticles for biomedical delivery applications Chem. Soc. Rev. 41 7 2012 2545 2561
5. M.E. Davis, Z. Chen, and D.M. Shin Nanoparticle therapeutics: An emerging treatment modality for cancer Nat. Rev. Drug Discovery 7 9 2008 771 782
6. M. Witting, M. Molina, K. Obst, R. Plank, K.M. Eckl, H.C. Hennies, and et al. Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules Nanomedicine 11 5 2015 1179 1187
7. E.S. Lee, Z. Gao, and Y.H. Bae Recent progress in tumor pH targeting nanotechnology J. Controlled Release 132 3 2008 164 170
8. N. Bertrand, J. Wu, X. Xu, N. Kamaly, and O.C. Farokhzad Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology Adv. Drug Delivery Rev. 66 0 2014 2 25
9. M. Li, W. Song, Z. Tang, S. Lv, L. Lin, H. Sun, and et al. Nanoscaled poly(l-glutamic acid)/doxorubicin-amphiphile complex as pH-responsive drug delivery system for effective treatment of nonsmall cell lung cancer ACS Appl. Mater. Interfaces 5 5 2013 1781 1792
10. J.O. Kim, A.V. Kabanov, and T.K. Bronich Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin J. Controlled Release 138 3 2009 197 204
11. J. Ding, W. Xu, Y. Zhang, D. Sun, C. Xiao, D. Liu, and et al. Self-reinforced endocytoses of smart polypeptide nanogels for "on-demand" drug delivery J. Controlled Release 172 2 2013 444 455
12. F. Shi, J. Ding, C. Xiao, X. Zhuang, C. He, L. Chen, and et al. Intracellular microenvironment responsive PEGylated polypeptide nanogels with ionizable cores for efficient doxorubicin loading and triggered release J. Mater. Chem. 22 28 2012 14168 14179
13. J. Peng, T. Qi, J. Liao, B. Chu, Q. Yang, W. Li, and et al. Controlled release of cisplatin from pH-thermal dual responsive nanogels Biomaterials 34 34 2013 8726 8740
14. J. Chen, J. Ouyang, J. Kong, W. Zhong, and M.M. Xing Photo-cross-linked and pH-sensitive biodegradable micelles for doxorubicin delivery ACS Appl. Mater. Interfaces 5 8 2013 3108 3117
15. H.-C. Wang, Y. Zhang, C.M. Possanza, S.C. Zimmerman, J. Cheng, J.S. Moore, and et al. Trigger chemistries for better industrial formulations ACS Appl. Mater. Interfaces 7 12 2015 6369 6382
16. A.V. Kabanov, and S.V. Vinogradov Nanogels as pharmaceutical carriers: Finite networks of infinite capabilities Angew. Chem., Int. Ed. 48 30 2009 5418 5429
17. M. Molina, M. Asadian-Birjand, J. Balach, J. Bergueiro, E. Miceli, and M. Calderon Stimuli-responsive nanogel composites and their application in nanomedicine Chem. Soc. Rev. 44 2015 6161 6186
18. D. Klinger, E.M. Aschenbrenner, C.K. Weiss, and K. Landfester Enzymatically degradable nanogels by inverse miniemulsion copolymerization of acrylamide with dextran methacrylates as crosslinkers Polym. Chem. 3 1 2012 204 216
19. D. Steinhilber, M. Witting, X. Zhang, M. Staegemann, F. Paulus, W. Friess, and et al. Surfactant free preparation of biodegradable dendritic polyglycerol nanogels by inverse nanoprecipitation for encapsulation and release of pharmaceutical biomacromolecules J. Controlled Release 169 3 2013 289 295
20. J.C. Cuggino, I.C.I. Alvarez, M.C. Strumia, P. Welker, K. Licha, D. Steinhilber, and et al. Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications Soft Matter 7 23 2011 11259 11266
21. M. Asadian-Birjand, J. Bergueiro, F. Rancan, J.C. Cuggino, R.C. Mutihac, K. Achazi, and et al. Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration Polym. Chem. 6 2015 5827 5831
22. M. Molina, M. Giulbudagian, and M. Calderón Positively charged thermoresponsive nanogels for anticancer drug delivery Macromol. Chem. Phys. 215 24 2014 2414 2419
23. Y. Chen, X. Zheng, X. Wang, C. Wang, Y. Ding, and X. Jiang Near-infrared emitting gold cluster-poly(acrylic acid) hybrid nanogels ACS Macro Lett. 3 1 2013 74 76
24. Y. Chen, X. Zheng, H. Qian, Z. Mao, D. Ding, and X. Jiang Hollow core-porous shell structure poly(acrylic acid) nanogels with a superhigh capacity of drug loading ACS Appl. Mater. Interfaces 2 12 2010 3532 3538
25. Y. Zhan, M. Goncalves, P. Yi, D. Capelo, Y. Zhang, J. Rodrigues, and et al. Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery J. Mater. Chem. B 3 20 2015 4221 4230
26. M. Das, S. Mardyani, W.C.W. Chan, and E. Kumacheva Biofunctionalized pH-responsive microgels for cancer cell targeting: Rational design Adv. Mater. 18 1 2006 80 83
27. M.J. Serpe, K.A. Yarmey, C.M. Nolan, and L.A. Lyon Doxorubicin uptake and release from microgel thin films Biomacromolecules 6 1 2005 408 413
28. W. Zhang, Z. Mao, and C. Gao Preparation of TAT peptide-modified poly(N-isopropylacrylamide) microgel particles and their cellular uptake, intracellular distribution, and influence on cytoviability in response to temperature change J. Colloid Interface Sci. 434 2014 122 129
29. J. Nan, Y. Chen, R. Li, J. Wang, M. Liu, Wang, and F. Chu Polymeric hydrogel nanocapsules: A thermo and pH dual-responsive carrier for sustained drug release Nano-Micro Lett. 6 3 2014 200 208
30. A.H. Faraji, and P. Wipf Nanoparticles in cellular drug delivery Bioorg. Med. Chem. 17 8 2009 2950 2962