The use of inhaled antibiotic therapy in the treatment of ventilator-associated pneumonia and tracheobronchitis: A systematic review

BMC Pulmonary Medicine

Volumn 16, Issue 1, 2016, Pages

  Russell, Christopher J ^a,b   Shiroishi, Mark S ^b   Siantz, Elizabeth ^c   Wu, Brian W ^b   Patino, Cecilia M ^b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aerosolized; Antibiotics; Inhaled; Therapy; Ventilator associated pneumonia

Indexed keywords

AMIKACIN; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CEFTAZIDIME; CIPROFLOXACIN; COLISTIMETHATE; TOBRAMYCIN; ANTIINFECTIVE AGENT;

AEROSOL; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL PULMONARY INFECTION SCORE; DRUG EFFICACY; EVIDENCE BASED MEDICINE; HUMAN; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; SYSTEMATIC REVIEW; TRACHEOBRONCHITIS; VENTILATOR; VENTILATOR ASSOCIATED PNEUMONIA; ADVERSE EFFECTS; ARTIFICIAL VENTILATION; BRONCHITIS; CROSS INFECTION; INHALATIONAL DRUG ADMINISTRATION; MECHANICAL VENTILATOR; PNEUMONIA, VENTILATOR-ASSOCIATED; RESPIRATORY TRACT INFECTIONS; TRACHEITIS;

ADMINISTRATION, INHALATION; ANTI-BACTERIAL AGENTS; BRONCHITIS; CROSS INFECTION; HUMANS; PNEUMONIA, VENTILATOR-ASSOCIATED; RESPIRATION, ARTIFICIAL; RESPIRATORY TRACT INFECTIONS; TRACHEITIS; VENTILATORS, MECHANICAL;

EID: 84960107024     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/s12890-016-0202-8     Document Type: Article

References (15)

1. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med. 2002;165:867-903.
2. Susan E, Coffin MM, Michael Klompas MD, David Classen MM, Kathleen M, Arias MC, et al. Strategies to prevent ventilator associated pneumonia in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S31-40.
3. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005, 171:388-416.
4. Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis. 2005;41:848-54.
5. Ferrari F, Lu Q, Girardi C, Petitjean O, Marquette CH, Wallet F, et al. Nebulized ceftazidime in experimental pneumonia caused by partially resistant Pseudomonas aeruginosa. Intensive Care Med. 2009;35:1792-800.
6. Lu Q, Girardi C, Zhang M, Bouhemad B, Louchahi K, Petitjean O, et al. Nebulized and intravenous colistin in experimental pneumonia caused by Pseudomonas aeruginosa. Intensive Care Med. 2010;36:1147-55.
7. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
8. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
9. Hallal A, Cohn SM, Namias N, Habib F, Baracco G, Manning RJ, et al. Aerosolized tobramycin in the treatment of ventilator-associated pneumonia: a pilot study. Surg Infect (Larchmt). 2007;8:73-82.
10. Lu Q, Yang J, Liu Z, Gutierrez C, Aymard G, Rouby JJ. Nebulized ceftazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Am J Respir Crit Care Med. 2011;184:106-15.
11. Niederman MS, Chastre J, Corkery K, Fink JB, Luyt CE, Garcia MS. BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia. Intensive Care Med. 2012;38:263-71.
12. Palmer LB, Smaldone GC, Chen JJ, Baram D, Duan T, Monteforte M, et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med. 2008;36:2008-13.
13. Palmer LB, Smaldone GC. Reduction of bacterial resistance with inhaled antibiotics in the intensive care unit. Am J Respir Crit Care Med. 2014;189:1225-33.
14. Rattanaumpawan P, Lorsutthitham J, Ungprasert P, Angkasekwinai N, Thamlikitkul V. Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria. J Antimicrob Chemother. 2010;65:2645-9.
15. Rouby JJ, Bouhemad B, Monsel A, Brisson H, Arbelot C, Lu Q. Aerosolized antibiotics for ventilator-associated pneumonia: lessons from experimental studies. Anesthesiology. 2012;117:1364-80.