Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos?

Human Reproduction

Volumn 31, Issue 2, 2016, Pages 370-376

  Drakopoulos, Panagiotis ^a   Blockeel, Christophe ^a   Stoop, Dominic ^a   Camus, Michel ^a   De Vos, Michel ^a   Tournaye, Herman ^a   Polyzos, Nikolaos P ^a,b  

^a CENTRE FOR REPRODUCTIVE MEDICINE   (Belgium)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Cumulative live birth; Live birth rate; Ovarian response; Ovarian stimulation; Single embryo transfer

Indexed keywords

GONADORELIN ANTAGONIST; GONADOTROPIN; RECOMBINANT FOLLITROPIN; FOLLITROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; EMBRYO; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FREEZE THAWING; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MAJOR CLINICAL STUDY; OOCYTE; OVARY HYPERSTIMULATION; RETROSPECTIVE STUDY; TREATMENT RESPONSE; VITRIFICATION; BIRTH RATE; DRUG EFFECTS; IN VITRO FERTILIZATION; MULTIVARIATE ANALYSIS; OOCYTE RETRIEVAL; OVARY; OVULATION INDUCTION; PREGNANCY; PROCEDURES; SINGLE EMBRYO TRANSFER; STATISTICAL MODEL;

ADULT; BIRTH RATE; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; HUMANS; LOGISTIC MODELS; MULTIVARIATE ANALYSIS; OOCYTE RETRIEVAL; OVARY; OVULATION INDUCTION; PREGNANCY; RETROSPECTIVE STUDIES; SINGLE EMBRYO TRANSFER; SPERM INJECTIONS, INTRACYTOPLASMIC;

EID: 84959897069     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev316     Document Type: Article

References (25)

1. Arce JC, Andersen AN, Fernandez-Sanchez M, Visnova H, Bosch E, Garcia-Velasco JA, Barri P, de Sutter P, Klein BM, Fauser BC. Ovarian response to recombinant human follicle-stimulating hormone: A randomized, antimullerian hormone-stratified, dose-response trial in women undergoing in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril 2014; 102:1633-1640 e1635.
2. Baart EB, Martini E, Eijkemans MJ, Van Opstal D, Beckers NG, Verhoeff A, Macklon NS, Fauser BC. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: A randomized controlled trial. Hum Reprod 2007;22:980-988.
3. Baker VL, Brown MB, Luke B, Conrad KP. Association of number of retrieved oocytes with live birth rate and birthweight: An analysis of 231, 815 cycles of in vitro fertilization. Fertil Steril 2015;103:931-938 e932.
4. Briggs R, Kovacs G, MacLachlan V, Motteram C, Baker HW. Can you ever collect too many oocytes? Hum Reprod 2015;30:81-87.
5. Devroey P, PolyzosNP, Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment. Hum Reprod 2011;26:2593-2597.
6. Fatemi HM, Doody K, Griesinger G, Witjes H, Mannaerts B. High ovarian response does not jeopardize ongoing pregnancy rates and increases cumulative pregnancy rates in a GnRH-antagonist protocol. Hum Reprod 2013;28:442-452.
7. Fauser BC, Devroey P, Macklon NS. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet 2005;365:1807-1816.
8. Ferraretti AP, La Marca A, Fauser BC, Tarlatzis B, Nargund G, Gianaroli L, Definition EwgoPOR. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: The Bologna criteria. Hum Reprod 2011;26:1616-1624.
9. Ghobara T, Vandekerckhove P. Cycle regimens for frozen-thawed embryo transfer. Cochrane Database Syst Rev 2008: CD003414.
10. GlujovskyD, Pesce R, Fiszbajn G, Sueldo C, Hart RJ, Ciapponi A. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived fromdonor oocytes. Cochrane Database Syst Rev 2010: CD006359.
11. Golan A, Ron-el R, Herman A, Soffer Y, Weinraub Z, Caspi E. Ovarian hyperstimulation syndrome: An update review. Obstet Gynecol Surv 1989; 44:430-440.
12. HaafT, Hahn A, Lambrecht A, Grossmann B, Schwaab E, Khanaga O, HahnT, Tresch A, Schorsch M. A high oocyte yield for intracytoplasmic sperm injection treatment is associated with an increased chromosome error rate. Fertil Steril 2009;91:733-738.
13. Humaidan P, Polyzos NP, Alsbjerg B, Erb K, Mikkelsen AL, Elbaek HO, Papanikolaou EG, Andersen CY. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation: Two prospective randomized controlled multi-centre studies in IVF patients. Hum Reprod 2013;28:2511-2521.
14. Ji J, Liu Y, Tong XH, Luo L, Ma J, Chen Z. The optimum number of oocytes in IVF treatment: An analysis of 2455 cycles in China. Hum Reprod 2013; 28:2728-2734.
15. Joo BS, Park SH, An BM, Kim KS, Moon SE, Moon HS. Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner. Fertil Steril 2010;93:442-446.
16. Kok JD, Looman CW, Weima SM, te Velde ER. A high number of oocytes obtained after ovarian hyperstimulation for in vitro fertilization or intracytoplasmic sperm injection is not associated with decreased pregnancy outcome. Fertil Steril 2006;85:918-924.
17. Papanikolaou EG, Pozzobon C, Kolibianakis EM, Camus M, Tournaye H, Fatemi HM, Van Steirteghem A, Devroey P. Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropinreleasing hormone antagonist in vitro fertilization cycles. Fertil Steril 2006; 85:112-120.
18. PolyzosNP, Sunkara SK. Sub-optimal responders following controlled ovarian stimulation: An overlooked group? Hum Reprod 2015;30:2005-2008.
19. Steward RG, Lan L, Shah AA, Yeh JS, Price TM, Goldfarb JM, Muasher SJ. Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: An analysis of 256, 381 in vitro fertilization cycles. Fertil Steril 2014;101:967-973.
20. Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: An analysis of 400 135 treatment cycles. Hum Reprod 2011;26:1768-1774.
21. Timeva T, Milachich T, Antonova I, Arabaji T, Shterev A, Omar HA. Correlation between number of retrieved oocytes and pregnancy rate after in vitro fertilization/intracytoplasmic sperm infection. Scientific World Journal 2006;6:686-690.
22. Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A, Simon C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril 2001;76:962-968.
23. van de Vijver A, Polyzos NP, Van Landuyt L, De Vos M, Camus M, Stoop D, Tournaye H, Blockeel C. Cryopreserved embryo transfer in an artificial cycle: is GnRH agonist down-regulation necessary? Reprod Biomed Online 2014;29:588-594.
24. van der Gaast MH, Eijkemans MJ, van der Net JB, de Boer EJ, BurgerCW, van Leeuwen FE, Fauser BC, Macklon NS. Optimum number of oocytes for a successful first IVF treatment cycle. Reprod Biomed Online 2006; 13:476-480.
25. Van Landuyt L, Stoop D, Verheyen G, Verpoest W, Camus M, Van de Velde H, Devroey P, Van den Abbeel E. Outcome of closed blastocyst vitrification in relation to blastocyst quality: evaluation of 759 warming cycles in a single-embryo transfer policy. Hum Reprod 2011; 26:527-534.