Comparison of iron status 28 d after provision of antimalarial treatment with iron therapy compared with antimalarial treatment alone in Ugandan children with severe malaria

American Journal of Clinical Nutrition

Volumn 103, Issue 3, 2016, Pages 919-925

  Cusick, Sarah E ^a   Opoka, Robert O ^b   Ssemata, Andrew S ^b   Georgieff, Michael K ^a   John, Chandy C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MAKERERE UNIVERSITY   (Uganda)

Author keywords

Hepcidin; Inflammation; Iron; Malaria; Timing of iron supplementation

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTESUNATE; BENFLUMETOL; C REACTIVE PROTEIN; FERRITIN; FERROUS SULFATE; HEMOGLOBIN; HEPCIDIN; PROTOPORPHYRIN ZINC; QUININE; BIOLOGICAL MARKER; IRON INTAKE; PROTOPORPHYRIN;

ANEMIA; ARTICLE; BRAIN MALARIA; CHILD; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEMOGLOBIN DETERMINATION; HUMAN; IRON DEFICIENCY; IRON THERAPY; MAJOR CLINICAL STUDY; MALARIA; MALE; PRESCHOOL CHILD; SEVERE MALARIAL ANEMIA; UGANDA; ADMINISTRATION AND DOSAGE; BLOOD; COMPARATIVE STUDY; COMPLICATION; DIETARY SUPPLEMENT; DRUG ADMINISTRATION; DRUG INTERACTION; INFLAMMATION; IRON INTAKE; MALARIA, CEREBRAL; METABOLISM; NUTRITIONAL STATUS; PHARMACOLOGY; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX; THERAPEUTIC USE;

ANEMIA; ANTIMALARIALS; BIOMARKERS; C-REACTIVE PROTEIN; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; FEMALE; FERRITINS; HEMOGLOBINS; HEPCIDINS; HUMANS; INFLAMMATION; IRON, DIETARY; MALARIA; MALARIA, CEREBRAL; MALE; NUTRITIONAL STATUS; PROTOPORPHYRINS; SEVERITY OF ILLNESS INDEX; UGANDA;

EID: 84959885316     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.117820     Document Type: Article

References (21)

1. Sazawal S, Black RE, Ramsan M, Chwaya HM, Dutta A, Dhingra U, Stoltzfus RJ, Othman MK, Kabole FM. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006; 367:133-43
2. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. BMJ 1978;2:1113-5
3. Trousseau A. True and false chlorosis. In: Lectures on clinical medicine. Philadelphia (PA): Lindsay & Blakiston; 1872. p. 95-117
4. World Health Organization. Conclusions and recommendations of the WHO Consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas. Food Nutr Bull 2007;28(4 Suppl):S621-7
5. Desai MR, Mei JV, Kariuki SK, Wannemuehler KA, Phillips-Howard PA, Nahlen BL, Kager PA, Vulule JM, ter Kuile FO. Randomized, controlled trial of daily iron supplementation and intermittent sulfadoxine- pyrimethamine for the treatment of mild childhood anemia in western Kenya. J Infect Dis 2003;187:658-66
6. Nwanyanwu OC, Ziba C, Kazembe PN, Gamadzi G, Gandwe J, Redd SC. The effect of oral iron therapy during treatment for Plasmodium falciparum malaria with sulphadoxine-pyrimethamine on Malawian children under 5 years of age. Ann Trop Med Parasitol 1996;90:589-95
7. Verhoef H, West CE, Nzyuko SM, de Vogel S, van der Valk R, Wanga MA, Kuijsten A, Veenemans J, Kok FJ. Intermittent administration of iron and sulfadoxine-pyrimethamine to control anaemia in Kenyan children: a randomised controlled trial. Lancet 2002;360:908-14
8. Doherty CP, Cox SE, Fulford AJ, Austin S, Hilmers DC, Abrams SA, Prentice AM. Iron incorporation and post-malaria anaemia. PLoS One 2008;3:e2133
9. de Mast Q, Nadjm B, Reyburn H, Kemna EH, Amos B, Laarakkers CM, Silalye S, Verhoef H, Sauerwein RW, Swinkels DW, et al. Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection. J Infect Dis 2009;199:253-62
10. Frosch AE, Ondigo BN, Ayodo GA, Vulule JM, John CC, Cusick SE. Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr 2014;100:968-73
11. Verhoef H, West CE, Kraaijenhagen R, Nzyuko SM, King R, Mbandi MM, van Laatum S, Hogervorst R, Schep C, Kok FJ. Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children. Blood 2002;100:3489-94
12. WHO. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity [Internet]. Vitamin and Mineral Nutrition Information System. [cited 2016 Jan 3]. Geneva (Switzerland): World Health Organization; 2011 (WHO/NMH/NHD/MNM/11.1). Available from: http://www.who.int/vmnis/indicators/haemoglobin.pdf
13. Guiang SF, Georgieff MK, Lamber DJ. Schmidt, Widness. Intravenous iron supplementation effect on tissue iron and hemoproteins in chronically phlebotomized lambs. Am J Physiol 1997; 273:R2124-31
14. Glinz D, Hurrell RF, Ouattara M, Zimmermann MB, Brittenham GM, Adiossan LG, Righetti AA, Seifert B, Diakite VG, Utzinger J, et al. The effect of iron-fortified complementary food and intermittent preventative treatement of malaria on anaemia in 12- to 36-monthold children: a cluster-randomised controlled trial. Malar J 2015; 14:347
15. Wieringa FT, Dijkhuizen MA, West CE, Northrop-Clewes CA, Muhilal. Estimation of the effect of the acute phase response on indicators of micronutrient status in indonesian infants. J Nutr 2002;132:3061-6
16. Prentice AM, Doherty CP, Abrams SA, Cox SE, Atkinson SH, Verhoef H, Armitage AE, Drakesmith H. Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children. Blood 2012; 119:1922-8
17. Glinz D, Kamiyango M, Phiri KS, Munthali F, Zeder C, Zimmermann MB, Hurrell RF, Wegmüller R. The effect of timing of iron supplementation on iron absorption and haemoglobin in post-malaria anaemia: a longitudinal stable isotope study in Malawian toddlers. Malar J 2014;13:397
18. Pasricha SR, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY. Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Sci Transl Med 2014;6:235re3
19. Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702
20. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta 2012;1823:1434-43
21. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44