Ageing, inflammation, and oxidative stress: Final common pathways of cardiovascular disease

European Heart Journal

Volumn 36, Issue 48, 2015, Pages 3381-3383

  Lüscher, Thomas F ^a  

^a Careum Campus ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH DIFFERENTIATION FACTOR; GROWTH DIFFERENTIATION FACTOR 11; HEME OXYGENASE 1; MYOSTATIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SIRTUIN; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR INFLAMMATION; CARDIOVASCULAR MORTALITY; GENE EXPRESSION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; MITOCHONDRION; MONOCYTE; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIMARY PREVENTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REVIEW; RHEUMATOID ARTHRITIS; AGE; CARDIOVASCULAR DISEASES; MYOCARDITIS; PHYSIOLOGY;

AGE FACTORS; CARDIOVASCULAR DISEASES; HUMANS; MYOCARDITIS; OXIDATIVE STRESS;

EID: 84959880724     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehv679     Document Type: Review

References (25)

1. Braunwald E. The rise of cardiovascular medicine. Eur Heart J 2012;33: 838-845, 45a.
2. Townsend N, Nichols M, Scarborough P, Rayner M. Cardiovascular disease in Europe: epidemiological update 2015. Eur Heart J 2015;36:2696-2705.
3. Castell MV, van der Pas S, Otero A, Siviero P, Dennison E, Denkinger M, Pedersen N, Sanchez-Martinez M, Queipo R, van Schoor N, Zambon S, Edwards M, Peter R, Schaap L, Deeg D. Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on OSteo-Arthritis (EPOSA). BMC Musculoskelet Disord 2015;16:359.
4. Taylor J. The cardiovascular component in dementia. Eur Heart J 2014;35: 1301-1302.
5. Ghosh AK, Hardy RJ, Francis DP, Chaturvedi N, Pellerin D, Deanfield J, Kuh D, Mayet J, Hughes AD. Midlife blood pressure change and left ventricular mass and remodelling in older age in the 1946 British Birth Cohort Study. Eur Heart J 2014;35: 3287-3295.
6. Camici GG, Savarese G, Akhmedov A, Luscher TF. Molecular mechanism of endothelial and vascular ageing: implications for cardiovascular disease. Eur Heart J 2015; 36:3392-3403.
7. Brun CE, Rudnicki MA. GDF11 and the mythical Fountain of Youth. Cell Metab 2015;22:54-56.
8. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur AN, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circulating growth differentiation factor 11/8 levels decline with age. Circ Res 2015;in press.
9. Masi S, D'Aiuto F, Martin-Ruiz C, Kahn T, Wong A, Ghosh AK, Whincup P, Kuh D, Hughes A, von Zglinicki T, Hardy R, Deanfield JE. Rate of telomere shortening and cardiovascular damage: A longitudinal study in the 1946 British Birth Cohort. Eur Heart J 2014;35:3296-3303.
10. Winnik S, Auwerx J, Sinclair DA, Matter CM. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J 2015;36:3404-3412.
11. Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, Luscher TF, Matter CM. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/-mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. Eur Heart J 2015;36:51-59.
12. Breitenstein A, Wyss CA, Spescha RD, Franzeck FC, Hof D, Riwanto M, Hasun M, Akhmedov A, von Eckardstein A, MaierW, Landmesser U, Luscher TF, Camici GG. Peripheral blood monocyte Sirt1 expression is reduced in patients with coronary artery disease. PLoS One 2013;8:e53106.
13. Olson KA, Beatty AL, Heidecker B, Regan MC, Brody EN, Foreman T, Kato S, Mehler RE, Singer BS, Hveem K, Dalen H, Sterling DG, Lawn RM, Schiller NB, Williams SA, Whooley MA, Ganz P. Association of growth differentiation factor 11/8, putative anti-ageing factor, with cardiovascular outcomes and overall mortality in humans: Analysis of the Heart and Soul and HUNT3 cohorts. Eur Heart J 2015; 36:3426-3434.
14. Thum T. Antiageing concepts and cardiovascular disease. Eur Heart J 2015;36: 3435-3436.
15. Ridker PM, Luscher TF. Anti-inflammatory therapies for cardiovascular disease. Eur Heart J 2014;35:17821791.
16. Mason JC, Libby P. Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur Heart J 2015;36:482-489c.
17. Mantel A, Holmqvist M, Jernberg T, Wallberg-Jonsson S, Askling J. Rheumatoid arthritis is associated with a more severe presentation of acute coronary syndrome and worse short-term outcome. Eur Heart J 2015;36:3413-3422.
18. Klingenberg R, Luscher TF. Rheumatoid arthritis and coronary atherosclerosis: Two cousins engaging in a dangerous liaison. Eur Heart J 2015;36:3423-3425.
19. Fredenburgh LE, Merz AA, Cheng S. Haem oxygenase signalling pathway: implications for cardiovascular disease. Eur Heart J 2015;36:1512-1518.
20. Wenzel P, Rossmann H, Muller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schonfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Hauser F, Beutel ME, Kroller-Schon S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Munzel T. Haem oxygenase-1 suppresses a proinflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. Eur Heart J 2015;36:3437-3446.
21. Schurmann C, Rezende F, Kruse C, Yasar Y, Lowe O, Fork C, van de Sluis B, Bremer R, Weissmann N, Shah AM, Jo H, Brandes RP, Schroder K. The NADPH oxidase Nox4 has antiatherosclerotic functions. Eur Heart J 2015;36:3447-3456.
22. Langbein H, Brunssen C, Hofmann A, Cimalla P, Brux M, Bornstein SR, Deussen A, Koch E, Morawietz H. NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor-deficient mice. Eur Heart J 2015; doi:10. 1093/eurheartj/ehv564. Published online ahead of print 17 November 2015.
23. Miller FJ Jr. Nox4 NADPH oxidase: emerging from the veil of darkness. Eur Heart J 2015;36:3457-3459.
24. Yusuf S. A 35-year journey to evidence-based medicine: A personal story. Eur Heart J 2015;36:3460-3466.
25. McMurray JJJV. Improving outcomes in heart failure: A personal perspective. Eur Heart J 2015;36:3467-3470.