Role of intestinal microbiota in transplantation outcomes

Best Practice and Research: Clinical Haematology

Volumn 28, Issue 2-3, 2015, Pages 155-161

  Taur, Ying ^a,c   Jenq, Robert R ^a,c   Ubeda, Carles ^b   Van Den Brink, Marcel ^a,c   Pamer, Eric G ^a,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Centro Superior de Investigacion en Salud Publica   (Spain)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Allo HSCT; Bacteremia; Diversity; Intestinal microbiota; Metronidazole; Microbial dominance; Mortality; Survival

Indexed keywords

BACTERIAL RNA; CIPROFLOXACIN; LEVOFLOXACIN; METRONIDAZOLE; RNA 16S; VANCOMYCIN; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANAEROBIC BACTERIUM; ARTICLE; BACTEREMIA; CANCER CHEMOTHERAPY; CANCER SURGERY; ENGRAFTMENT; ENTEROCOCCUS; FECES ANALYSIS; HEMATOLOGIC MALIGNANCY; HUMAN; INFECTION RISK; INTESTINE FLORA; MICROBIAL DIVERSITY; NONHUMAN; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; PROTEOBACTERIA; PYROSEQUENCING; STREPTOCOCCUS; SURGICAL MORTALITY; CLINICAL TRIAL (TOPIC); GRAFT VS HOST DISEASE; GROWTH, DEVELOPMENT AND AGING; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MICROBIOLOGY; MORTALITY; OPPORTUNISTIC INFECTIONS; PATHOGENICITY; PATHOLOGY; RISK FACTOR; SURVIVAL ANALYSIS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACTEREMIA; CLINICAL TRIALS AS TOPIC; GASTROINTESTINAL MICROBIOME; GRAFT VS HOST DISEASE; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; METRONIDAZOLE; OPPORTUNISTIC INFECTIONS; RISK FACTORS; SURVIVAL ANALYSIS; VANCOMYCIN; VANCOMYCIN-RESISTANT ENTEROCOCCI;

EID: 84959861184     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2015.10.013     Document Type: Review

References (13)

1. P.B. Eckburg, E.M. Bik, C.N. Bernstein, E. Purdom, L. Dethlefsen, M. Sargent, and et al. Diversity of the human intestinal microbial flora Science 308 2005 1635 1638
2. E.J. Vollaard, and H.A. Clasener Colonization resistance Antimicrob Agents Chemother 38 1994 409 414
3. D.J. Hentges, and R. Freter In vivo and in vitro antagonism of intestinal bacteria against Shigella flexneri. I. Correlation between various tests J Infect Dis 110 1962 30 37
4. The Human Microbiome Project Consortium Structure, function and diversity of the healthy human microbiome Nature 486 2012 207 214
5. M.I. Smith, T. Yatsunenko, M.J. Manary, I. Trehan, R. Mkakosya, J. Cheng, and et al. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor Science 339 2013 548 554
6. P.J. Turnbaugh, R.E. Ley, M.A. Mahowald, V. Magrini, E.R. Mardis, and J.I. Gordon An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 2006 1027 1031
7. J.U. Scher, A. Sczesnak, R.S. Longman, N. Segata, C. Ubeda, C. Bielski, and et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis Elife 2 2013 e01202
8. N. Iida, A. Dzutsev, C.A. Stewart, L. Smith, N. Bouladoux, R.A. Weingarten, and et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment Science 342 2013 967 970
9. S. Viaud, F. Saccheri, G. Mignot, T. Yamazaki, R. Daillere, D. Hannani, and et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide Science 342 2013 971 976
10. E.A. Copelan Hematopoietic stem-cell transplantation N Engl J Med 354 2006 1813 1826
11. C. Ubeda, Y. Taur, R.R. Jenq, M.J. Equinda, T. Son, M. Samstein, and et al. Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans J Clin Invest 120 2010 4332 4341
12. Y. Taur, J.B. Xavier, L. Lipuma, C. Ubeda, J. Goldberg, A. Gobourne, and et al. Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation Clin Infect Dis 55 2012 905 914
13. Y. Taur, R.R. Jenq, M.A. Perales, E.R. Littmann, S. Morjaria, L. Ling, and et al. The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation Blood 124 2014 1174 1182