Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 9, 2016, Pages E1190-E1199

  Chen, Yu ^a,b   Seepersaud, Ravin ^c,d   Bensing, Barbara A ^c,d   Sullam, Paul M ^c,d   Rapoport, Tom A ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bacterial adhesin; Crystal structure; Enzymatic mechanism; O glycosylation; Ser Thr rich repeats

Indexed keywords

ADHESIN; BACTERIAL ADHESION PROTEIN; BACTERIAL PROTEIN; GLYCOSYLTRANSFERASE; GTFA PROTEIN; GTFB PROTEIN; N ACETYLGLUCOSAMINE; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS LINKING; CRYSTALLIZATION; DISSOCIATION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN GLYCOSYLATION; PROTEIN SYNTHESIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS GORDONII; BACTERIUM ADHERENCE; BIOSYNTHESIS; CHEMISTRY; CYTOSOL; DIMERIZATION; ENZYMOLOGY; GRAM POSITIVE BACTERIUM; METABOLISM; MOLECULAR MODEL; X RAY CRYSTALLOGRAPHY;

BACTERIAL ADHESION; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; DIMERIZATION; GLYCOSYLTRANSFERASES; GRAM-POSITIVE BACTERIA; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 84959541355     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600494113     Document Type: Article

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