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Volumn 51, Issue 3, 2016, Pages 417-428

Intensification of insulin therapy with basal-bolus or premixed insulin regimens in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials

Author keywords

Basal bolus; Insulin regimens; Meta analysis; Premix; Type 2 diabetes

Indexed keywords

GLITAZONE DERIVATIVE; HEMOGLOBIN A1C; INSULIN; INSULIN ASPART; INSULIN GLARGINE; INSULIN GLULISINE; INSULIN LISPRO; PIOGLITAZONE; ANTIDIABETIC AGENT; GLYCOSYLATED HEMOGLOBIN;

EID: 84959511533     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-015-0718-3     Document Type: Article
Times cited : (66)

References (42)
  • 1
    • 84907511294 scopus 로고    scopus 로고
    • Trends in lifetime risk and years of life lost due to diabetes in the USA, 1985–2011: a modelling study
    • PID: 25128274
    • E.W. Gregg, X. Zhuo, Y.J. Cheng, A.L. AlbrighL, K.M. Narayan, T.J. Thompson, Trends in lifetime risk and years of life lost due to diabetes in the USA, 1985–2011: a modelling study. Lancet Diabetes Endocrinol 2, 867–874 (2014)
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 867-874
    • Gregg, E.W.1    Zhuo, X.2    Cheng, Y.J.3    AlbrighL, A.L.4    Narayan, K.M.5    Thompson, T.J.6
  • 2
    • 84935860987 scopus 로고    scopus 로고
    • 7. Approaches to glycemic treatment
    • American Diabetes Association, 7. Approaches to glycemic treatment. Diabetes Care 38(Suppl. 1), S41–S48 (2015)
    • (2015) Diabetes Care , vol.38 , pp. 41-48
    • American Diabetes Association1
  • 4
    • 84857029848 scopus 로고    scopus 로고
    • Proportion of patients at HbA1c target <7 % with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78,945 patients
    • COI: 1:CAS:528:DC%2BC38XltFKksr0%3D, PID: 21958121
    • K. Esposito, P. Chiodini, G. Bellastella, M.I. Maiorino, D. Giugliano, Proportion of patients at HbA1c target <7 % with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78,945 patients. Diabetes Obes. Metab. 14, 228–233 (2012)
    • (2012) Diabetes Obes. Metab , vol.14 , pp. 228-233
    • Esposito, K.1    Chiodini, P.2    Bellastella, G.3    Maiorino, M.I.4    Giugliano, D.5
  • 7
    • 55449131463 scopus 로고    scopus 로고
    • Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs
    • Orals Plus Apidra and LANTUS (OPAL) study group, M.R. Lankisch, K.C. Ferlinz, J.L. Leahy, W.A. Scherbaum, Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs. Diabetes Obes. Metab. 10, 1178–1185 (2008)
    • (2008) Diabetes Obes. Metab , vol.10 , pp. 1178-1185
    • Orals Plus Apidra and LANTUS (OPAL) study group1    Lankisch, M.R.2    Ferlinz, K.C.3    Leahy, J.L.4    Scherbaum, W.A.5
  • 8
    • 79959645873 scopus 로고    scopus 로고
    • A stepwise approach to insulin therapy in patients with type 2 diabetes mellitus and basal insulin treatment failure
    • M.B. Davidson, P. Raskin, R.J. Tanenberg, A. Vlajnic, P. Hollander, A stepwise approach to insulin therapy in patients with type 2 diabetes mellitus and basal insulin treatment failure. Endocr. Pract. 17, 395–403 (2001)
    • (2001) Endocr. Pract , vol.17 , pp. 395-403
    • Davidson, M.B.1    Raskin, P.2    Tanenberg, R.J.3    Vlajnic, A.4    Hollander, P.5
  • 9
    • 33646014162 scopus 로고    scopus 로고
    • Attainment of glycaemic goals in type 2 diabetes with once-, twice-, or thrice-daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study)
    • COI: 1:CAS:528:DC%2BD28XitFyjsro%3D, PID: 16367883
    • A.J. Garber, J. Wahlen, T. Wahl, P. Bressler, R. Braceras, E. Allen, R. Jain, Attainment of glycaemic goals in type 2 diabetes with once-, twice-, or thrice-daily dosing with biphasic insulin aspart 70/30 (The 1-2-3 study). Diabetes Obes. Metab. 8, 58–66 (2006)
    • (2006) Diabetes Obes. Metab , vol.8 , pp. 58-66
    • Garber, A.J.1    Wahlen, J.2    Wahl, T.3    Bressler, P.4    Braceras, R.5    Allen, E.6    Jain, R.7
  • 10
    • 84891785293 scopus 로고    scopus 로고
    • Intensification of insulin therapy for type 2 diabetic patients in primary care: basal-bolus regimen versus premix insulin analogs: when and for whom?
    • COI: 1:CAS:528:DC%2BC3sXhtl2ksrvP, PID: 23882048
    • O. Mosenzon, I. Raz, Intensification of insulin therapy for type 2 diabetic patients in primary care: basal-bolus regimen versus premix insulin analogs: when and for whom? Diabetes Care 36(Suppl 2), S212–S218 (2013)
    • (2013) Diabetes Care , vol.36 , pp. 212-218
    • Mosenzon, O.1    Raz, I.2
  • 11
    • 84863999251 scopus 로고    scopus 로고
    • A retrospective database study of insulin initiation in patients with Type 2 diabetes in UK primary care
    • COI: 1:STN:280:DC%2BC38rlsV2isw%3D%3D, PID: 22507537
    • B.T. Blak, H.T. Smith, M. Hards, A. Maguire, V. Gimeno, A retrospective database study of insulin initiation in patients with Type 2 diabetes in UK primary care. Diabet. Med. 29, e191–e198 (2012)
    • (2012) Diabet. Med , vol.29 , pp. 191-198
    • Blak, B.T.1    Smith, H.T.2    Hards, M.3    Maguire, A.4    Gimeno, V.5
  • 13
    • 85009116013 scopus 로고    scopus 로고
    • Glycemic control in insulinized type 2 diabetes patients in China: one-year results from IDMPS. American Diabetes Association 69th Scientific Sessions
    • J.L. Li, W. Jia, J. Weng, Glycemic control in insulinized type 2 diabetes patients in China: one-year results from IDMPS. American Diabetes Association 69th Scientific Sessions, New Orleans, 2009
    • (2009) New Orleans
    • Li, J.L.1    Jia, W.2    Weng, J.3
  • 17
    • 85100415918 scopus 로고    scopus 로고
    • (ed.), Cochrane Handbook for Systematic Reviews of Interventions (The Cochrane Collaboration, 5.1.0
    • J.P.T. Higgins, S. Green (ed.), Cochrane Handbook for Systematic Reviews of Interventions (The Cochrane Collaboration, 5.1.0. Oxford, 2011)
    • (2011) Oxford
    • Higgins, J.P.T.1    Green, S.2
  • 18
    • 84948773232 scopus 로고    scopus 로고
    • Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis
    • Egger MD-SG, Altman DG, (eds), BMJ Publishing, London
    • J.J.A.D. Deeks, M.J. Bradburn, Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis, in Systematic Reviews in Health Care, ed. by M.D.-S.G. Egger, D.G. Altman (BMJ Publishing, London, 2001), pp. 285–312
    • (2001) Systematic Reviews in Health Care , pp. 285-312
    • Deeks, J.J.A.D.1    Bradburn, M.J.2
  • 19
    • 84937545705 scopus 로고    scopus 로고
    • Similar glucose control with basal-bolus regimen of insulin detemir plus insulin aspart and thrice-daily biphasic insulin aspart 30 in insulin-naive patients with type 2 diabetes: Results of a 50-week randomized clinical trial of stepwise insulin intensification
    • PID: 25483023
    • R. Malek, F. Ajili, S.H. Assaad-Khalil, A. Shinde, J.W. Chen, E. Van den Berg, Similar glucose control with basal-bolus regimen of insulin detemir plus insulin aspart and thrice-daily biphasic insulin aspart 30 in insulin-naive patients with type 2 diabetes: Results of a 50-week randomized clinical trial of stepwise insulin intensification. Diabetes Metab. (2014). doi:10.1016/j.diabet.2014.11.002
    • (2014) Diabetes Metab
    • Malek, R.1    Ajili, F.2    Assaad-Khalil, S.H.3    Shinde, A.4    Chen, J.W.5    Van den Berg, E.6
  • 20
    • 84925260966 scopus 로고    scopus 로고
    • Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial
    • COI: 1:CAS:528:DC%2BC2MXhsFSlt73I, PID: 25754414
    • W. Jia, X. Xiao, Q. Ji, K.-J. Ahn, L.-M. Chuang, Y. Bao, C. Pang, L. Chen, F. Gao, Y. Tu, P. Li, J. Yang, Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial. Lancet Diabetes Endocrinol. 3, 254–262 (2015)
    • (2015) Lancet Diabetes Endocrinol , vol.3 , pp. 254-262
    • Jia, W.1    Xiao, X.2    Ji, Q.3    Ahn, K.-J.4    Chuang, L.-M.5    Bao, Y.6    Pang, C.7    Chen, L.8    Gao, F.9    Tu, Y.10    Li, P.11    Yang, J.12
  • 21
    • 84893096457 scopus 로고    scopus 로고
    • Initiation and gradual intensification of premixed insulin lispro therapy versus basal ± mealtime insulin in patients with type 2 diabetes eating light breakfasts
    • COI: 1:CAS:528:DC%2BC2cXks1Cqtbo%3D, PID: 24170763
    • D. Giugliano, M. Tracz, S. Shah, A. Calle-Pascual, C. Mistodie, R. Duarte, R. Sari, V. Woo, A.O. Jiletcovici, J. Deinhard, S.A. Wille, J. Kiljanski, Initiation and gradual intensification of premixed insulin lispro therapy versus basal ± mealtime insulin in patients with type 2 diabetes eating light breakfasts. Diabetes Care 37, 372–380 (2014)
    • (2014) Diabetes Care , vol.37 , pp. 372-380
    • Giugliano, D.1    Tracz, M.2    Shah, S.3    Calle-Pascual, A.4    Mistodie, C.5    Duarte, R.6    Sari, R.7    Woo, V.8    Jiletcovici, A.O.9    Deinhard, J.10    Wille, S.A.11    Kiljanski, J.12
  • 22
    • 84912080001 scopus 로고    scopus 로고
    • Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial
    • COI: 1:CAS:528:DC%2BC2cXhsFahtbvF, PID: 24725616
    • F.J. Tinahones, J.L. Gross, A. Onaca, S. Cleall, A. Rodríguez, Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial. Diabetes Obes. Metab. 16, 963–970 (2014)
    • (2014) Diabetes Obes. Metab , vol.16 , pp. 963-970
    • Tinahones, F.J.1    Gross, J.L.2    Onaca, A.3    Cleall, S.4    Rodríguez, A.5
  • 23
    • 84898826853 scopus 로고    scopus 로고
    • Randomized, 1-year comparison of three ways to initiate and advance insulin for type 2 diabetes: twice-daily premixed insulin versus basal insulin with either basal-plus one prandial insulin or basal-bolus up to three prandial injections
    • COI: 1:CAS:528:DC%2BC2cXmsFWrt7g%3D, PID: 24118931
    • M.C. Riddle, J. Rosenstock, A. Vlajnic, L. Gao, Randomized, 1-year comparison of three ways to initiate and advance insulin for type 2 diabetes: twice-daily premixed insulin versus basal insulin with either basal-plus one prandial insulin or basal-bolus up to three prandial injections. Diabetes Obes. Metab. 16, 396–402 (2014)
    • (2014) Diabetes Obes. Metab , vol.16 , pp. 396-402
    • Riddle, M.C.1    Rosenstock, J.2    Vlajnic, A.3    Gao, L.4
  • 24
    • 84865124273 scopus 로고    scopus 로고
    • A study comparing insulin lispro mix 25 with glargine plus lispro therapy in patients with Type 2 diabetes who have inadequate glycaemic control on oral anti-hyperglycaemic medication: results of the PARADIGM study
    • COI: 1:STN:280:DC%2BC38npsVSjug%3D%3D, PID: 22672081
    • K. Bowering, V.A. Reed, J.S. Felicio, J. Landry, L. Ji, J. Oliveira, A study comparing insulin lispro mix 25 with glargine plus lispro therapy in patients with Type 2 diabetes who have inadequate glycaemic control on oral anti-hyperglycaemic medication: results of the PARADIGM study. Diabet. Med. 29, e263–e272 (2012)
    • (2012) Diabet. Med , vol.29 , pp. 263-272
    • Bowering, K.1    Reed, V.A.2    Felicio, J.S.3    Landry, J.4    Ji, L.5    Oliveira, J.6
  • 25
    • 79960245792 scopus 로고    scopus 로고
    • L.A: Bromberger, M. Bhushan, R. Bhushan, Glycemic control with insulin glargine plus insulin glulisine versus premixed insulin analogues in real-world practices: a cost-effectiveness study with a randomized pragmatic trial design
    • COI: 1:CAS:528:DC%2BC3MXptVygs74%3D, PID: 21719107
    • P.A. Levin, Q. Zhang, J.H. Mersey, F.Y. Lee, L.A: Bromberger, M. Bhushan, R. Bhushan, Glycemic control with insulin glargine plus insulin glulisine versus premixed insulin analogues in real-world practices: a cost-effectiveness study with a randomized pragmatic trial design. Clin. Ther. 33, 841–850 (2011)
    • (2011) Clin. Ther , vol.33 , pp. 841-850
    • Levin, P.A.1    Zhang, Q.2    Mersey, J.H.3    Lee, F.Y.4
  • 26
    • 73349140858 scopus 로고    scopus 로고
    • GINGER study group, Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study
    • COI: 1:CAS:528:DC%2BC3cXitlWjsbg%3D, PID: 20092584
    • A. Fritsche, M. Larbig, D. Owens, H.U. Häring, GINGER study group, Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study. Diabetes Obes. Metab. 12, 115–123 (2010)
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 115-123
    • Fritsche, A.1    Larbig, M.2    Owens, D.3    Häring, H.U.4
  • 27
    • 77954783077 scopus 로고    scopus 로고
    • Randomized, open-label, parallel-group evaluations of basal-bolus therapy versus insulin lispro premixed therapy in patients with type 2 diabetes mellitus failing to achieve control with starter insulin treatment and continuing oral antihyperglycemic drugs: a noninferiority intensification substudy of the DURABLE trial
    • COI: 1:CAS:528:DC%2BC3cXosVWqu74%3D, PID: 20685497
    • W.F. Miser, R. Arakaki, H. Jiang, J. Scism-Bacon, P.W. Anderson, J.L. Fahrbach, Randomized, open-label, parallel-group evaluations of basal-bolus therapy versus insulin lispro premixed therapy in patients with type 2 diabetes mellitus failing to achieve control with starter insulin treatment and continuing oral antihyperglycemic drugs: a noninferiority intensification substudy of the DURABLE trial. Clin. Ther. 32, 896–908 (2010)
    • (2010) Clin. Ther , vol.32 , pp. 896-908
    • Miser, W.F.1    Arakaki, R.2    Jiang, H.3    Scism-Bacon, J.4    Anderson, P.W.5    Fahrbach, J.L.6
  • 28
    • 77957279506 scopus 로고    scopus 로고
    • Prandial-basal insulin regimens plus oral antihyperglycaemic agents to improve mealtime glycaemia: initiate and progressively advance insulin therapy in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhsVymurvE, PID: 20880343
    • S.M. Jain, X. Mao, M. Escalante-Pulido, N. Vorokhobina, I. Lopez, L.L. Ilag, Prandial-basal insulin regimens plus oral antihyperglycaemic agents to improve mealtime glycaemia: initiate and progressively advance insulin therapy in type 2 diabetes. Diabetes Obes. Metab. 12, 967–975 (2010)
    • (2010) Diabetes Obes. Metab , vol.12 , pp. 967-975
    • Jain, S.M.1    Mao, X.2    Escalante-Pulido, M.3    Vorokhobina, N.4    Lopez, I.5    Ilag, L.L.6
  • 29
    • 58149177354 scopus 로고    scopus 로고
    • Comparison of insulin analogue regimens in people with type 2 diabetes mellitus in the PREFER Study: a randomized controlled trial
    • PREFER Study Group, A. Liebl, R. Prager, K. Binz, M. Kaiser, R. Bergenstal, B. Gallwitz, Comparison of insulin analogue regimens in people with type 2 diabetes mellitus in the PREFER Study: a randomized controlled trial. Diabetes Obes. Metab. 11, 45–52 (2009)
    • (2009) Diabetes Obes. Metab , vol.11 , pp. 45-52
    • PREFER Study Group1    Liebl, A.2    Prager, R.3    Binz, K.4    Kaiser, M.5    Bergenstal, R.6    Gallwitz, B.7
  • 30
    • 38149073314 scopus 로고    scopus 로고
    • Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal-bolus (glargine/lispro) therapy
    • COI: 1:CAS:528:DC%2BD1cXhs1ejtrs%3D, PID: 17934150
    • J. Rosenstock, A.J. Ahmann, G. Colon, J. Scism-Bacon, H. Jiang, S. Martin, Advancing insulin therapy in type 2 diabetes previously treated with glargine plus oral agents: prandial premixed (insulin lispro protamine suspension/lispro) versus basal-bolus (glargine/lispro) therapy. Diabetes Care 31, 20–25 (2008)
    • (2008) Diabetes Care , vol.31 , pp. 20-25
    • Rosenstock, J.1    Ahmann, A.J.2    Colon, G.3    Scism-Bacon, J.4    Jiang, H.5    Martin, S.6
  • 31
    • 33845309408 scopus 로고    scopus 로고
    • Biphasic insulin aspart given thrice daily is as efficacious as a basal-bolus insulin regimen with four daily injections: a randomised open-label parallel group four months comparison in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD28Xht1yksbfM, PID: 17115349
    • R.J. Ligthelm, U. Mouritzen, H. Lynggaard, M. Landin-Olsson, C. Fox, C. le Devehat, E. Romero, A. Liebl, Biphasic insulin aspart given thrice daily is as efficacious as a basal-bolus insulin regimen with four daily injections: a randomised open-label parallel group four months comparison in patients with type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 114, 511–519 (2006)
    • (2006) Exp. Clin. Endocrinol. Diabetes , vol.114 , pp. 511-519
    • Ligthelm, R.J.1    Mouritzen, U.2    Lynggaard, H.3    Landin-Olsson, M.4    Fox, C.5    le Devehat, C.6    Romero, E.7    Liebl, A.8
  • 32
    • 79955796825 scopus 로고    scopus 로고
    • Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus
    • European Medicines Agency, Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. CPMP/EWP/1080/00 Rev. 1. 14 May 2012. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2012/06/WC500129256.pdf. Accessed 27 Apr 2015
    • (2012) CPMP/EWP/1080/00 Rev , vol.1 , pp. 14
  • 33
    • 84977878634 scopus 로고    scopus 로고
    • Guidance for industry diabetes mellitus: developing drugs and therapeutic biologics for treatment and prevention
    • Food and Drug Administration, Guidance for industry diabetes mellitus: developing drugs and therapeutic biologics for treatment and prevention. draft guidance (2008). http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm071627.pdf. Accessed 17 Apr 2015
    • (2008) draft guidance
  • 34
    • 79951717317 scopus 로고    scopus 로고
    • Efficacy of insulin analogs in achieving the hemoglobin A1c target of <7 % in type 2 diabetes: meta-analysis of randomized controlled trials
    • COI: 1:CAS:528:DC%2BC3MXis1Crur0%3D, PID: 21216850
    • D. Giugliano, M.I. Maiorino, G. Bellastella, P. Chiodini, A. Ceriello, K. Esposito, Efficacy of insulin analogs in achieving the hemoglobin A1c target of <7 % in type 2 diabetes: meta-analysis of randomized controlled trials. Diabetes Care 34, 510–517 (2011)
    • (2011) Diabetes Care , vol.34 , pp. 510-517
    • Giugliano, D.1    Maiorino, M.I.2    Bellastella, G.3    Chiodini, P.4    Ceriello, A.5    Esposito, K.6
  • 35
    • 84884728188 scopus 로고    scopus 로고
    • Real world outcomes of adding rapid-acting insulin versus switching to analog premix insulin among US patients with type 2 diabetes treated with insulin glargine
    • PID: 24086105
    • R. Miao, W. Wei, O. Baser, L. Xie, Real world outcomes of adding rapid-acting insulin versus switching to analog premix insulin among US patients with type 2 diabetes treated with insulin glargine. Patient Prefer Adherence 7, 951–960 (2013)
    • (2013) Patient Prefer Adherence , vol.7 , pp. 951-960
    • Miao, R.1    Wei, W.2    Baser, O.3    Xie, L.4
  • 38
    • 79954583330 scopus 로고    scopus 로고
    • Treatment regimens with insulin analogues and haemoglobin A1c target of <7 % in type 2 diabetes: a systematic review
    • COI: 1:CAS:528:DC%2BC3MXkvFGhtbw%3D, PID: 20822821
    • D. Giugliano, M.I. Maiorino, G. Bellastella, P. Chiodini, K. Esposito, Treatment regimens with insulin analogues and haemoglobin A1c target of <7 % in type 2 diabetes: a systematic review. Diabetes Res. Clin. Pract. 92, 1–10 (2011)
    • (2011) Diabetes Res. Clin. Pract , vol.92 , pp. 1-10
    • Giugliano, D.1    Maiorino, M.I.2    Bellastella, G.3    Chiodini, P.4    Esposito, K.5
  • 40
    • 84901806502 scopus 로고    scopus 로고
    • Safety and effectiveness of biphasic insulin aspart 30 in people with type 2 diabetes switching from basal-bolus insulin regimens in the A1chieve study
    • PID: 23953707
    • G. Dieuzeide, L.M. Chuang, A. Almaghamsi, A. Zilov, J.W. Chen, F.J. Lavalle-González, Safety and effectiveness of biphasic insulin aspart 30 in people with type 2 diabetes switching from basal-bolus insulin regimens in the A1chieve study. Prim Care Diabetes 8, 111–117 (2014)
    • (2014) Prim Care Diabetes , vol.8 , pp. 111-117
    • Dieuzeide, G.1    Chuang, L.M.2    Almaghamsi, A.3    Zilov, A.4    Chen, J.W.5    Lavalle-González, F.J.6
  • 41
    • 84879536305 scopus 로고    scopus 로고
    • Switching from premixed insulin to basal-bolus insulin glargine plus rapid-acting insulin: the ATLANTIC study
    • COI: 1:STN:280:DC%2BC3srpsVGltA%3D%3D, PID: 23627191
    • C. Mathieu, F. Storms, J. Tits, T.F. Veneman, I.M. Colin, Switching from premixed insulin to basal-bolus insulin glargine plus rapid-acting insulin: the ATLANTIC study. Acta Clin. Belg. 68, 28–33 (2013)
    • (2013) Acta Clin. Belg , vol.68 , pp. 28-33
    • Mathieu, C.1    Storms, F.2    Tits, J.3    Veneman, T.F.4    Colin, I.M.5
  • 42
    • 84926434235 scopus 로고    scopus 로고
    • Comparative cardiovascular morbidity and mortality in patients taking different insulin regimens for type 2 diabetes: a systematic review
    • PID: 25762229
    • H.I. Price, M.D. Agnew, J.-M. Gamble, Comparative cardiovascular morbidity and mortality in patients taking different insulin regimens for type 2 diabetes: a systematic review. BMJ Open 5, e006341 (2015)
    • (2015) BMJ Open , vol.5 , pp. 6341
    • Price, H.I.1    Agnew, M.D.2    Gamble, J.-M.3


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