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Volumn 23, Issue 3, 2016, Pages 329-336

Volumetric tumor response and progression in EGFR-mutant NSCLC patients treated with erlotinib or gefitinib

Author keywords

EGFR mutations; Lung cancer; Non small cell; Tumor volume; Tyrosine kinase inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE;

EID: 84959493869     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2015.11.005     Document Type: Article
Times cited : (33)

References (46)
  • 1
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris M.G., Johnson B.E., Berry L.D., et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 2014, 311:1998-2006.
    • (2014) JAMA , vol.311 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3
  • 2
    • 84896918973 scopus 로고    scopus 로고
    • State of the art: response assessment in lung cancer in the era of genomic medicine
    • Nishino M., Hatabu H., Johnson B.E., et al. State of the art: response assessment in lung cancer in the era of genomic medicine. Radiology 2014, 271:6-27.
    • (2014) Radiology , vol.271 , pp. 6-27
    • Nishino, M.1    Hatabu, H.2    Johnson, B.E.3
  • 3
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 4
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., Janne P.A., Lee J.C., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 5
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W., Miller V., Zakowski M., et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004, 101:13306-13311.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 6
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • Zhou C., Wu Y.L., Chen G., et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011, 12:735-742.
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 8
    • 45149084723 scopus 로고    scopus 로고
    • First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    • Sequist L.V., Martins R.G., Spigel D., et al. First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008, 26:2442-2449.
    • (2008) J Clin Oncol , vol.26 , pp. 2442-2449
    • Sequist, L.V.1    Martins, R.G.2    Spigel, D.3
  • 9
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok T.S., Wu Y.L., Thongprasert S., et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009, 361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 10
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M., Inoue A., Kobayashi K., et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010, 362:2380-2388.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 11
    • 33746034167 scopus 로고    scopus 로고
    • Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
    • Jackman D.M., Yeap B.Y., Sequist L.V., et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006, 12:3908-3914.
    • (2006) Clin Cancer Res , vol.12 , pp. 3908-3914
    • Jackman, D.M.1    Yeap, B.Y.2    Sequist, L.V.3
  • 12
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • Rosell R., Carcereny E., Gervais R., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012, 13:239-246.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 13
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • 75ra26
    • Sequist L.V., Waltman B.A., Dias-Santagata D., et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011, 3:75ra26.
    • (2011) Sci Transl Med , vol.3
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3
  • 14
    • 78649905395 scopus 로고    scopus 로고
    • CT tumor volume measurement in advanced non-small-cell lung cancer: performance characteristics of an emerging clinical tool
    • Nishino M., Guo M., Jackman D.M., et al. CT tumor volume measurement in advanced non-small-cell lung cancer: performance characteristics of an emerging clinical tool. Acad Radiol 2011, 18:54-62.
    • (2011) Acad Radiol , vol.18 , pp. 54-62
    • Nishino, M.1    Guo, M.2    Jackman, D.M.3
  • 15
    • 84859118421 scopus 로고    scopus 로고
    • Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST
    • Nishino M., Jagannathan J.P., Krajewski K.M., et al. Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST. AJR Am J Roentgenol 2012, 198:737-745.
    • (2012) AJR Am J Roentgenol , vol.198 , pp. 737-745
    • Nishino, M.1    Jagannathan, J.P.2    Krajewski, K.M.3
  • 16
    • 0038352143 scopus 로고    scopus 로고
    • Interobserver and intraobserver variability in measurement of non-small-cell carcinoma lung lesions: implications for assessment of tumor response
    • Erasmus J.J., Gladish G.W., Broemeling L., et al. Interobserver and intraobserver variability in measurement of non-small-cell carcinoma lung lesions: implications for assessment of tumor response. J Clin Oncol 2003, 21:2574-2582.
    • (2003) J Clin Oncol , vol.21 , pp. 2574-2582
    • Erasmus, J.J.1    Gladish, G.W.2    Broemeling, L.3
  • 17
    • 84862915437 scopus 로고    scopus 로고
    • Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer
    • Mozley P.D., Bendtsen C., Zhao B., et al. Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer. Transl Oncol 2012, 5:19-25.
    • (2012) Transl Oncol , vol.5 , pp. 19-25
    • Mozley, P.D.1    Bendtsen, C.2    Zhao, B.3
  • 18
    • 77956126688 scopus 로고    scopus 로고
    • Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence
    • Mozley P.D., Schwartz L.H., Bendtsen C., et al. Change in lung tumor volume as a biomarker of treatment response: a critical review of the evidence. Ann Oncol 2010, 21:1751-1755.
    • (2010) Ann Oncol , vol.21 , pp. 1751-1755
    • Mozley, P.D.1    Schwartz, L.H.2    Bendtsen, C.3
  • 19
    • 67650085792 scopus 로고    scopus 로고
    • Evaluating variability in tumor measurements from same-day repeat CT scans of patients with non-small cell lung cancer
    • Zhao B., James L.P., Moskowitz C.S., et al. Evaluating variability in tumor measurements from same-day repeat CT scans of patients with non-small cell lung cancer. Radiology 2009, 252:263-272.
    • (2009) Radiology , vol.252 , pp. 263-272
    • Zhao, B.1    James, L.P.2    Moskowitz, C.S.3
  • 20
    • 33846651571 scopus 로고    scopus 로고
    • Lung cancer: computerized quantification of tumor response-initial results
    • Zhao B., Schwartz L.H., Moskowitz C.S., et al. Lung cancer: computerized quantification of tumor response-initial results. Radiology 2006, 241:892-898.
    • (2006) Radiology , vol.241 , pp. 892-898
    • Zhao, B.1    Schwartz, L.H.2    Moskowitz, C.S.3
  • 21
    • 84880924699 scopus 로고    scopus 로고
    • Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI
    • Nishino M., Dahlberg S.E., Cardarella S., et al. Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI. J Thorac Oncol 2013, 8:1059-1068.
    • (2013) J Thorac Oncol , vol.8 , pp. 1059-1068
    • Nishino, M.1    Dahlberg, S.E.2    Cardarella, S.3
  • 22
    • 0017395129 scopus 로고
    • Solid tumor models for assessment of different treatment modalities: therapeutic strategy for sequential chemotherapy with radiotherapy
    • Looney W.B., Trefil J.S., Hopkins H.A., et al. Solid tumor models for assessment of different treatment modalities: therapeutic strategy for sequential chemotherapy with radiotherapy. Proc Natl Acad Sci U S A 1977, 74:1983-1987.
    • (1977) Proc Natl Acad Sci U S A , vol.74 , pp. 1983-1987
    • Looney, W.B.1    Trefil, J.S.2    Hopkins, H.A.3
  • 23
    • 0024330777 scopus 로고
    • An exponential-Gompertzian description of LoVo cell tumor growth from in vivo and in vitro data
    • Demicheli R., Foroni R., Ingrosso A., et al. An exponential-Gompertzian description of LoVo cell tumor growth from in vivo and in vitro data. Cancer Res 1989, 49:6543-6546.
    • (1989) Cancer Res , vol.49 , pp. 6543-6546
    • Demicheli, R.1    Foroni, R.2    Ingrosso, A.3
  • 24
    • 80755139581 scopus 로고    scopus 로고
    • Tumour growth rates and RECIST criteria in early drug development
    • Gomez-Roca C., Koscielny S., Ribrag V., et al. Tumour growth rates and RECIST criteria in early drug development. Eur J Cancer 2011, 47:2512-2516.
    • (2011) Eur J Cancer , vol.47 , pp. 2512-2516
    • Gomez-Roca, C.1    Koscielny, S.2    Ribrag, V.3
  • 25
    • 79951826832 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy
    • Stein W.D., Gulley J.L., Schlom J., et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 2011, 17:907-917.
    • (2011) Clin Cancer Res , vol.17 , pp. 907-917
    • Stein, W.D.1    Gulley, J.L.2    Schlom, J.3
  • 26
    • 84859871183 scopus 로고    scopus 로고
    • Analyzing the pivotal trial that compared sunitinib and IFN-alpha in renal cell carcinoma, using a method that assesses tumor regression and growth
    • Stein W.D., Wilkerson J., Kim S.T., et al. Analyzing the pivotal trial that compared sunitinib and IFN-alpha in renal cell carcinoma, using a method that assesses tumor regression and growth. Clin Cancer Res 2012, 18:2374-2381.
    • (2012) Clin Cancer Res , vol.18 , pp. 2374-2381
    • Stein, W.D.1    Wilkerson, J.2    Kim, S.T.3
  • 27
    • 84892188435 scopus 로고    scopus 로고
    • Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials
    • Ferte C., Fernandez M., Hollebecque A., et al. Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials. Clin Cancer Res 2014, 20:246-252.
    • (2014) Clin Cancer Res , vol.20 , pp. 246-252
    • Ferte, C.1    Fernandez, M.2    Hollebecque, A.3
  • 28
    • 84886091897 scopus 로고    scopus 로고
    • Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression
    • Nishino M., Dahlberg S.E., Cardarella S., et al. Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression. Cancer 2013, 119:3761-3768.
    • (2013) Cancer , vol.119 , pp. 3761-3768
    • Nishino, M.1    Dahlberg, S.E.2    Cardarella, S.3
  • 29
    • 84873166606 scopus 로고    scopus 로고
    • Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors
    • Nishino M., Cardarella S., Dahlberg S.E., et al. Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors. Lung Cancer 2013, 79:283-288.
    • (2013) Lung Cancer , vol.79 , pp. 283-288
    • Nishino, M.1    Cardarella, S.2    Dahlberg, S.E.3
  • 30
    • 84883396112 scopus 로고    scopus 로고
    • RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0
    • Nishino M., Cardarella S., Jackman D.M., et al. RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0. AJR Am J Roentgenol 2013, 201:W64-W71.
    • (2013) AJR Am J Roentgenol , vol.201 , pp. W64-W71
    • Nishino, M.1    Cardarella, S.2    Jackman, D.M.3
  • 31
    • 84903747034 scopus 로고    scopus 로고
    • Revisiting the relationship between tumour volume and diameter in advanced NSCLC patients: an exercise to maximize the utility of each measure to assess response to therapy
    • Nishino M., Jackman D.M., DiPiro P.J., et al. Revisiting the relationship between tumour volume and diameter in advanced NSCLC patients: an exercise to maximize the utility of each measure to assess response to therapy. Clin Radiol 2014, 69:841-848.
    • (2014) Clin Radiol , vol.69 , pp. 841-848
    • Nishino, M.1    Jackman, D.M.2    DiPiro, P.J.3
  • 32
    • 79957874894 scopus 로고    scopus 로고
    • The BATTLE to personalize lung cancer prevention through reverse migration
    • Gold K.A., Kim E.S., Lee J.J., et al. The BATTLE to personalize lung cancer prevention through reverse migration. Cancer Prev Res (Phila) 2011, 4:962-972.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 962-972
    • Gold, K.A.1    Kim, E.S.2    Lee, J.J.3
  • 33
    • 0020333131 scopus 로고
    • Random-effects models for longitudinal data
    • Laird N.M., Ware J.H. Random-effects models for longitudinal data. Biometrics 1982, 38:963-974.
    • (1982) Biometrics , vol.38 , pp. 963-974
    • Laird, N.M.1    Ware, J.H.2
  • 34
    • 84935085081 scopus 로고    scopus 로고
    • Alectinib: a review of its use in advanced ALK-rearranged non-small cell lung cancer
    • McKeage K. Alectinib: a review of its use in advanced ALK-rearranged non-small cell lung cancer. Drugs 2015, 75:75-82.
    • (2015) Drugs , vol.75 , pp. 75-82
    • McKeage, K.1
  • 35
    • 84922309383 scopus 로고    scopus 로고
    • Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases
    • 70.e1-2.
    • Sato T., Watanabe A., Kondo H., et al. Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases. J Thorac Cardiovasc Surg 2015, 149:64-69. 70.e1-2.
    • (2015) J Thorac Cardiovasc Surg , vol.149 , pp. 64-69
    • Sato, T.1    Watanabe, A.2    Kondo, H.3
  • 36
    • 84903864904 scopus 로고    scopus 로고
    • Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease
    • Kato M., Shukuya T., Takahashi F., et al. Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease. BMC Cancer 2014, 14:508.
    • (2014) BMC Cancer , vol.14 , pp. 508
    • Kato, M.1    Shukuya, T.2    Takahashi, F.3
  • 37
    • 84866934606 scopus 로고    scopus 로고
    • Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
    • Camidge D.R., Bang Y.J., Kwak E.L., et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012, 13:1011-1019.
    • (2012) Lancet Oncol , vol.13 , pp. 1011-1019
    • Camidge, D.R.1    Bang, Y.J.2    Kwak, E.L.3
  • 38
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak E.L., Bang Y.J., Camidge D.R., et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010, 363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 39
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw A.T., Kim D.W., Nakagawa K., et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013, 368:2385-2394.
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 40
    • 84878347085 scopus 로고    scopus 로고
    • CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study
    • Seto T., Kiura K., Nishio M., et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 2013, 14:590-598.
    • (2013) Lancet Oncol , vol.14 , pp. 590-598
    • Seto, T.1    Kiura, K.2    Nishio, M.3
  • 42
    • 84938208051 scopus 로고    scopus 로고
    • Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial
    • Soria J.C., Wu Y.L., Nakagawa K., et al. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol 2015, 16:990-998.
    • (2015) Lancet Oncol , vol.16 , pp. 990-998
    • Soria, J.C.1    Wu, Y.L.2    Nakagawa, K.3
  • 43
    • 84920931228 scopus 로고    scopus 로고
    • Ideal number of target lesions per organ to measure in metastatic colorectal cancer
    • Kim H.S., Kim J.H. Ideal number of target lesions per organ to measure in metastatic colorectal cancer. Oncol Lett 2014, 8:1896-1900.
    • (2014) Oncol Lett , vol.8 , pp. 1896-1900
    • Kim, H.S.1    Kim, J.H.2
  • 44
    • 84926410017 scopus 로고    scopus 로고
    • Tumor response assessment by measuring the single largest lesion per organ in patients with advanced non-small cell lung cancer
    • Kim H.S., Kim J.H., Yang I. Tumor response assessment by measuring the single largest lesion per organ in patients with advanced non-small cell lung cancer. Lung Cancer 2014, 85:385-389.
    • (2014) Lung Cancer , vol.85 , pp. 385-389
    • Kim, H.S.1    Kim, J.H.2    Yang, I.3
  • 45
    • 84920883506 scopus 로고    scopus 로고
    • Single-lesion measurement per organ for assessing tumor response in advanced gastric cancer
    • Kim H.S., Kim J.W., Kim J.H., et al. Single-lesion measurement per organ for assessing tumor response in advanced gastric cancer. Oncology 2014, 88:69-75.
    • (2014) Oncology , vol.88 , pp. 69-75
    • Kim, H.S.1    Kim, J.W.2    Kim, J.H.3
  • 46
    • 77955591119 scopus 로고    scopus 로고
    • Revised RECIST guideline version 1.1: what oncologists want to know and what radiologists need to know
    • Nishino M., Jagannathan J.P., Ramaiya N.H., et al. Revised RECIST guideline version 1.1: what oncologists want to know and what radiologists need to know. AJR Am J Roentgenol 2010, 195:281-289.
    • (2010) AJR Am J Roentgenol , vol.195 , pp. 281-289
    • Nishino, M.1    Jagannathan, J.P.2    Ramaiya, N.H.3


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