Genotoxicity in mice following AAV gene delivery: A safety concern for human gene therapy?

Molecular Therapy

Volumn 24, Issue 2, 2016, Pages 198-201

  Chandler, Randy J ^a   LaFave, Matthew C ^a   Varshney, Gaurav K ^a   Burgess, Shawn M ^a   Venditti, Charles P ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MICRORNA; MICRORNA 341; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG; ADENO ASSOCIATED VIRUS VECTOR; ALPHA FETOPROTEIN;

AGE; CANCER INCIDENCE; CARCINOGENESIS; CELLULAR IMMUNITY; DOSE RESPONSE; EXPOSURE; FGFR2 GENE; GENE EXPRESSION; GENE LOCUS; GENE THERAPY; GENOTOXICITY; GENOTYPE; HIGH THROUGHPUT SEQUENCING; HISTOPATHOLOGY; HUMAN; HUMORAL IMMUNITY; LENTIVIRINAE; LIVER CELL CARCINOMA; LOW DRUG DOSE; MIR341 GENE; MUTAGENESIS; NONHUMAN; NOTE; RTL1 GENE; SAFETY; TRANSGENE; TRANSPOSON; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS DNA CELL DNA INTERACTION; VIRUS RECOMBINANT; CLINICAL RESEARCH; GENE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; INBORN ERROR OF METABOLISM; NUCLEOTIDE REPEAT; PATIENT SAFETY; SEQUENCE HOMOLOGY; SEROTYPE; VIRAL GENE THERAPY; VIRUS GENOME; ADVERSE EFFECTS; ANIMAL; DEPENDOPARVOVIRUS; DNA DAMAGE; IMMUNOLOGY; MOUSE; PHYSIOLOGY; PRECLINICAL STUDY;

ANIMALS; DEPENDOVIRUS; DNA DAMAGE; DRUG EVALUATION, PRECLINICAL; GENETIC THERAPY; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MICE;

EID: 84959489142     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2016.17     Document Type: Note

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