Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike

PLoS Pathogens

Volumn 12, Issue 2, 2016, Pages

  Li, Sai ^a   Sun, Zhaoyang ^a   Pryce, Rhys ^a   Parsy, Marie Laure ^a   Fehling, Sarah K ^b   Schlie, Katrin ^b   Siebert, C Alistair ^a   Garten, Wolfgang ^b   Bowden, Thomas A ^a   Strecker, Thomas ^b   Huiskonen, Juha T ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; RIBONUCLEOPROTEIN; VIRUS SPIKE PROTEIN; GLYCOPROTEIN; LAMP1 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN BINDING; SIGNAL PEPTIDE; VIRUS ENVELOPE PROTEIN;

ACIDIFICATION; ACIDITY; ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CRYOELECTRON MICROSCOPY; ELECTRON TOMOGRAPHY; ENDOSOME; IMAGE PROCESSING; LASSA VIRUS; LYSOSOME; MDCK CELL LINE; NONHUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION; ULTRAVIOLET SPECTROSCOPY; VIRION; VIRUS ENVELOPE; VIRUS INACTIVATION; VIRUS LIKE AGENT; VIRUS MORPHOLOGY; VIRUS PURIFICATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; CONFORMATION; METABOLISM; MOLECULAR MODEL; PH; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE; VERO CELL LINE; VIRUS ENTRY;

ANIMALS; CERCOPITHECUS AETHIOPS; GLYCOPROTEINS; HYDROGEN-ION CONCENTRATION; LASSA VIRUS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRION; VIRUS INTERNALIZATION;

EID: 84959486075     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005418     Document Type: Article

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