The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis

European Journal of Neurology

Volumn 23, Issue 3, 2016, Pages 510-519

  Yaldizli, O ^a,b   Penner, I K ^c   Yonekawa, T ^d   Naegelin, Y ^a   Kuhle, J ^a   Pardini, M ^b,e   Chard, D T ^b,f   Stippich, C ^a   Kira, J I ^d   Bendfeldt, K ^g   Amann, M ^a,g   Radue, E W ^g   Kappos, L ^a   Sprenger, T ^a,h  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BASEL   (Switzerland)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF GENOA   (Italy)

^f UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^g Medical Image Analysis Center   (Switzerland)

^h DKD Helios Klinik Wiesbaden   (Germany)

Author keywords

Cognitive impairment; Depression; Fatigue; Magnetic resonance imaging; Multiple sclerosis; Olfactory bulb volume

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN SIZE; CLINICAL FEATURE; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DEPRESSION ASSESSMENT; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FATIGUE; FEMALE; FUNCTIONAL NEUROIMAGING; HUMAN; HYPOTHYROIDISM; IMAGING SOFTWARE; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OLFACTORY BULB VOLUME; PACED AUDITORY SERIAL ADDITION TEST; PHYSICAL DISABILITY; POLYP; PRIORITY JOURNAL; RELAPSE; REMISSION; SEX DIFFERENCE; WHITE MATTER LESION; ATROPHY; COGNITIVE DYSFUNCTION; COMPLICATION; MIDDLE AGED; OLFACTORY BULB; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; ATROPHY; COGNITIVE DYSFUNCTION; DEPRESSION; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; OLFACTORY BULB;

EID: 84959466143     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12891     Document Type: Article

References (38)

1. Denney DR, Sworowski LA, Lynch SG. Cognitive impairment in three subtypes of multiple sclerosis. Arch Clin Neuropsychol 2005; 20: 967-981.
2. Rao SM, Leo GJ, Ellington L, Nauertz T, Bernardin L, Unverzagt F. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 1991; 41: 692-696.
3. Bobholz JA, Rao SM. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol 2003; 16: 283-288.
4. Benedict RHB, Cox D, Thompson LL, Foley F, Weinstock-Guttman B, Munschauer F. Reliable screening for neuropsychological impairment in multiple sclerosis. Mult Scler 2004; 10: 675-678.
5. Thomann PA, Dos Santos V, Toro P, Schonknecht P, Essig M, Schroder J. Reduced olfactory bulb and tract volume in early Alzheimer's disease - a MRI study. Neurobiol Aging 2009; 30: 838-841.
6. Ponsen MM, Stoffers D, Booij J, van Eck-Smit BLF, Wolters EC, Berendse HW. Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 2004; 56: 173-181.
7. Silva AM, Santos E, Moreira I, et al. Olfactory dysfunction in multiple sclerosis: association with secondary progression. Mult Scler 2012; 18: 616-621.
8. Lois C, Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science 1994; 264: 1145-1148.
9. Nait-Oumesmar B, Picard-Riera N, Kerninon C, et al. Activation of the subventricular zone in multiple sclerosis: evidence for early glial progenitors. Proc Natl Acad Sci USA 2007; 104: 4694-4699.
10. Tepavčević V, Lazarini F, Alfaro-Cervello C, et al. Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis. J Clin Invest 2011; 121: 4722-4734.
11. Göktas O, Schmidt F, Bohner G, et al. Olfactory bulb volume and olfactory function in patients with multiple sclerosis. Rhinology 2011; 49: 221-226.
12. Solfrizzi V, Nardó GA, Panza F, Mastroianni F, Capurso A. Impact of aging on the relationships between impairment of 'Orientation' and 'Recall' items of MMSE and mild to moderate mood disorders. Arch Gerontol Geriatr 1996; 22(Suppl. 1): 69-72.
13. Siegert RJ, Abernethy DA. Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry 2005; 76: 469-475.
14. Diamond BJ, Johnson SK, Kaufman M, Graves L. Relationships between information processing, depression, fatigue and cognition in multiple sclerosis. Arch Clin Neuropsychol 2008; 23: 189-199.
15. Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the 'McDonald Criteria'. Ann Neurol 2005; 58: 840-846.
16. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996; 46: 907-911.
17. Gronwall DM. Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills 1977; 44: 367-373.
18. Smith A. Symbol Digit Modalities Test. Los Angeles: Western Psychological Services, 1989.
19. Calabrese P, Kalbe E, Kessler J. Das Multiple Sklerose Inventarium Cognition (MUSIC). Psychoneuro 2004; 30: 384-388.
20. Guedj E, Barbeau EJ, Didic M, et al. Identification of subgroups in amnestic mild cognitive impairment. Neurology 2006; 67: 356-358.
21. Deloire MSA, Salort E, Bonnet M, et al. Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2005; 76: 519-526.
22. Hautzinger M. Allgemeine Depressions Skala. Manual. Göttingen: Beltz Test GmbH, 1993.
23. Penner IK, Raselli C, Stocklin M, Opwis K, Kappos L, Calabrese P. The Fatigue Scale for Motor and Cognitive Functions (FSMC): validation of a new instrument to assess multiple sclerosis-related fatigue. Mult Scler 2009; 15: 1509-1517.
24. Yousry I, Camelio S, Schmid UD, et al. Visualization of cranial nerves I-XII: value of 3D CISS and T2-weighted FSE sequences. Eur Radiol 2000; 10: 1061-1067.
25. Brewer JB, Magda S, Airriess C, Smith ME. Fully-automated quantification of regional brain volumes for improved detection of focal atrophy in Alzheimer disease. AJNR Am J Neuroradiol 2009; 30: 578-580.
26. Rudick RA, Fisher E, Lee JC, Simon J, Jacobs L. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group. Neurology 1999; 53: 1698-1704.
27. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-1238.
28. Langdon DW, Amato MP, Boringa J, et al. Recommendations for a brief international cognitive assessment for multiple sclerosis (BICAMS). Mult Scler 2012; 18: 891-898.
29. Negoias S, Croy I, Gerber J, et al. Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 2010; 11: 415-421.
30. Göktas O, Fleiner F, Sedlmaier B, Bauknecht C. Correlation of olfactory dysfunction of different etiologies in MRI and comparison with subjective and objective olfactometry. Eur J Radiol 2009; 71: 469-473.
31. Zivadinov R, Zorzon M, Monti Bragadin L, Pagliaro G, Cazzato G. Olfactory loss in multiple sclerosis. J Neurol Sci 1999; 168: 127-130.
32. Savic I. Imaging of brain activation by odorants in humans. Curr Opin Neurobiol 2002; 12: 455-461.
33. Schmidt FA, Göktas O, Harms L, et al. Structural correlates of taste and smell loss in encephalitis disseminata. PLoS ONE 2011; 6: e19702.
34. Doty RL, Li C, Mannon LJ, Yousem DM. Olfactory dysfunction in multiple sclerosis. Relation to plaque load in inferior frontal and temporal lobes. Ann N Y Acad Sci 1998; 855: 781-786.
35. Pause BM, Raack N, Sojka B, Göder R, Aldenhoff JB, Ferstl R. Convergent and divergent effects of odors and emotions in depression. Psychophysiology 2003; 40: 209-225.
36. Boyd JH, Weissman MM, Thompson WD, Myers JK. Screening for depression in a community sample. Understanding the discrepancies between depression symptom and diagnostic scales. Arch Gen Psychiatry 1982; 39: 1195-1200.
37. Ackerman BH, Kasbekar N. Disturbances of taste and smell induced by drugs. Pharmacotherapy 1997; 17: 482-496.
38. Oxman AD, Guyatt GH. A consumer's guide to subgroup analyses. Ann Intern Med 1992; 116: 78-84.