Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

Journal of the American College of Cardiology

Volumn 67, Issue 4, 2016, Pages 407-416

  Keenan, Tanya ^a,b   Zhao, Wei ^a   Rasheed, Asif ^c   Ho, Weang K ^d   Malik, Rainer ^e   Felix, Janine F ^f,ak   Young, Robin ^d   Shah, Nabi ^c   Samuel, Maria ^c   Sheikh, Nasir ^d   Mucksavage, Megan L ^a   Shah, Omar ^a   Li, Jin ^g   Morley, Michael ^h   Laser, Annika ⁱ   Mallick, Nadeem Hayat ^j   Zaman, Khan Shah ^k   Ishaq, Mohammad ^l   Rasheed, Syed Zahed ^l   Memon, Fazal Ur Rehman ^m   Ahmed, Faisal ⁿ   Hanif, Bashir ^o   Lakhani, Muhammad Shakir ^o   Fahim, Muhammad ^c   Ishaq, Madiha ^c   Shardha, Naresh Kumar ^c   Ahmed, Naveeduddin ⁿ   Mahmood, Khalid ^p   Iqbal, Waseem ^q   Akhtar, Saba ^c   Raheel, Rabia ^c   O'Donnell, Christopher J ^b,r,s   Hengstenberg, Christian ^t   März, Winifred ^u,v,w   Kathiresan, Sekar ^b,s,x   Samani, Nilesh ^y   Goel, Anuj ^z   Hopewell, Jemma C ^aa   Chambers, John ^ab   Cheng, Yu Ching ^ac   Sharma, Pankaj ^ab   Yang, Qiong ^ad   Rosand, Jonathan ^b   Boncoraglio, Giorgio B ^ae   Kazmi, Shahana Urooj ^af   Hakonarson, Hakon ^g   Köttgen, Anna ^ag,ah   Kalogeropoulos, Andreas ^ai   Frossard, Philippe ^c   Kamal, Ayeesha ^aj   Dichgans, Martin ^e   Cappola, Thomas ^a   Reilly, Muredach P ^a   Danesh, John ^d   Rader, Daniel J ^a   Voight, Benjamin F ^h   Saleheen, Danish ^a,c,h   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Center for Non Communicable Diseases   (Pakistan)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ INSTITUTE OF EPIDEMIOLOGY   (Germany)

^j PUNJAB INSTITUTE OF CARDIOLOGY   (Pakistan)

^k NATIONAL INSTITUTE OF CARDIOVASCULAR DISEASES   (Pakistan)

^l Karachi Institute of Heart Diseases   (Pakistan)

^m Red Crescent Institute of Cardiology   (Pakistan)

ⁿ CIVIL HOSPITAL   (Pakistan)

^o Tabba Heart Institute   (Pakistan)

^p DOW UNIVERSITY OF HEALTH SCIENCES   (Pakistan)

^q Ameeruddin Medical College PGMI Lahore General Hospital M Phil Stud   (Pakistan)

^r FRAMINGHAM HEART STUDY   (United States)

^s HARVARD MEDICAL SCHOOL   (United States)

^t UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^u MEDICAL UNIVERSITY OF GRAZ   (Austria)

^v UNIVERSITY OF HEIDELBERG   (Germany)

^w SYNLAB ACADEMY   (Germany)

^x BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^y UNIVERSITY OF LEICESTER   (United Kingdom)

^z UNIVERSITY OF OXFORD   (United Kingdom)

^aa UNIVERSITY OF OXFORD   (United Kingdom)

^ab IMPERIAL COLLEGE LONDON   (United Kingdom)

^ac UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^ad BOSTON UNIVERSITY   (United States)

^ae DEPARTMENT OF NEUROSURGERY   (Italy)

^af UNIVERSITY OF KARACHI   (Pakistan)

^ag UNIVERSITY OF FREIBURG   (Germany)

^ah JOHNS HOPKINS UNIVERSITY   (United States)

^ai EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aj AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

^ak Netherlands Genomics Initiative   (Netherlands)

more..

Author keywords

genetic; pleiotropy; single nucleotide polymorphism

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 3; ANGIOPOIETIN LIKE PROTEIN 4; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN A5; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; ATAXIN 2; BLOOD CLOTTING FACTOR 7; CHOLESTEROL; CYSTATIN C; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EOTAXIN; FATTY ACID; FIBROBLAST GROWTH FACTOR 21; GELATINASE B; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PADGEM PROTEIN; STROMAL CELL DERIVED FACTOR 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; URATE; VASCULOTROPIN A; URIC ACID;

ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BRAIN ISCHEMIA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ESTIMATED GLOMERULUS FILTRATION RATE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC RISK SCORE; GENETIC VARIABILITY; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; GOUT; HEART FAILURE; HEART RATE; HEMOGLOBIN BLOOD LEVEL; HIP CIRCUMFERENCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; MENDELIAN RANDOMIZATION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; CLINICAL TRIAL; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; GENETICS; HEALTH; MORBIDITY; MULTICENTER STUDY; ODDS RATIO; PROCEDURES; PROGNOSIS; RISK ASSESSMENT; STROKE; TRENDS;

CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; GLOBAL HEALTH; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; MORBIDITY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RISK ASSESSMENT; RISK FACTORS; STROKE; URIC ACID;

EID: 84959420157     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.10.086     Document Type: Article

References (50)

1. J.H. Tayar, M.A. Lopez-Olivo, and M.E. Suarez-Almazor Febuxostat for treating chronic gout Cochrane Database Syst Rev 11 2012 CD008653
2. D.I. Feig, D.H. Kang, and R.J. Johnson Uric acid and cardiovascular risk N Engl J Med 359 2008 1811 1821
3. S. Kodama, K. Saito, Y. Yachi, and et al. Association between serum uric acid and development of type 2 diabetes Diabetes Care 32 2009 1737 1742
4. J.G. Wheeler, K.D. Juzwishin, G. Eiriksdottir, and et al. Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis PLoS Med 2 2005 e76
5. S.Y. Kim, J.P. Guevara, K.M. Kim, and et al. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis Arthritis Care Res (Hoboken) 62 2010 170 180
6. S.Y. Chuang, J.H. Chen, W.T. Yeh, and et al. Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort Int J Cardiol 154 2012 316 321
7. S. Kivity, E. Kopel, E. Maor, and et al. Association of serum uric acid and cardiovascular disease in healthy adults Am J Cardiol 111 2013 1146 1151
8. A. Hozawa, A.R. Folsom, H. Ibrahim, and et al. Serum uric acid and risk of ischemic stroke: the ARIC study Atherosclerosis 187 2006 401 407
9. S.Y. Kim, J.P. Guevara, K.M. Kim, and et al. Hyperuricemia and risk of stroke: a systematic review and meta-analysis Arthritis Rheum 61 2009 885 892
10. I. Holme, A.H. Aastveit, N. Hammar, and et al. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the apolipoprotein MOrtality RISk study (AMORIS) J Intern Med 266 2009 558 570
11. E. Krishnan Hyperuricemia and incident heart failure Circ Heart Fail 2 2009 556 562
12. D.A. Lawlor, R.M. Harbord, J.A. Sterne, and et al. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology Stat Med 27 2008 1133 1163
13. G. Davey Smith, and S. Ebrahim What can Mendelian randomisation tell us about modifiable behavioural and environmental exposures? Br Med J 330 2005 1076 1079
14. B.F. Voight, G.M. Peloso, M. Orho-Melander, and et al. Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study Lancet 380 2012 572 580
15. Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration N. Sarwar, M.S. Sandhu, and et al. Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies Lancet 375 2010 1634 1639
16. R. Clarke, J.F. Peden, J.C. Hopewell, and et al. Genetic variants associated with lp(a) lipoprotein level and coronary disease N Engl J Med 361 2009 2518 2528
17. P.R. Kamstrup, A. Tybjaerg-Hansen, R. Steffensen, and B.G. Nordestgaard Genetically elevated lipoprotein(a) and increased risk of myocardial infarction JAMA 301 2009 2331 2339
18. G. Ken-Dror, S.E. Humphries, M. Kumari, and et al. A genetic instrument for Mendelian randomization of fibrinogen Eur J Epidemiol 27 2012 267 279
19. P. Elliott, J.C. Chambers, W. Zhang, and et al. Genetic loci associated with C-reactive protein levels and risk of coronary heart disease JAMA 302 2009 37 48
20. R. Pfister, D. Barnes, R. Luben, and et al. No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach Diabetologia 54 2011 2561 2569
21. T.M. Palmer, B.G. Nordestgaard, M. Benn, and et al. Association of plasma uric acid with ischaemic heart disease and blood pressure: Mendelian randomisation analysis of two large cohorts BMJ 347 2013 f4262
22. K. Stark, W. Reinhard, M. Grassl, and et al. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease PLoS One 4 2009 e7729
23. Q. Yang, A. Kottgen, A. Dehghan, and et al. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors Circ Cardiovasc Genet 3 2010 523 530
24. D. Saleheen, M. Zaidi, A. Rasheed, and et al. The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in south Asia Eur J Epidemiol 24 2009 329 338
25. 1000 Genomes Project Consortium G.R. Abecasis, D. Altshuler, and et al. A map of human genome variation from population-scale sequencing Nature 467 2010 1061 1073
26. C. Newton-Cheh, T. Johnson, V. Gateva, and et al. Genome-wide association study identifies eight loci associated with blood pressure Nat Genet 41 2009 666 676
27. T.M. Teslovich, K. Musunuru, A.V. Smith, and et al. Biological, clinical and population relevance of 95 loci for blood lipids Nature 466 2010 707 713
28. I.M. Heid, A.U. Jackson, J.C. Randall, and et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat Genet 42 2010 949 960
29. H. Lango Allen, K. Estrada, G. Lettre, and et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height Nature 467 2010 832 838
30. E.K. Speliotes, C.J. Willer, S.I. Berndt, and et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index Nat Genet 42 2010 937 948
31. J. Dupuis, C. Langenberg, I. Prokopenko, and et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nat Genet 42 2010 105 116
32. R. Saxena, M.F. Hivert, C. Langenberg, and et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 42 2010 142 148
33. N. Soranzo, S. Sanna, E. Wheeler, and et al. Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways Diabetes 59 2010 3229 3239
34. R.J. Strawbridge, J. Dupuis, I. Prokopenko, and et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes Diabetes 60 2011 2624 2634
35. A.P. Morris, B.F. Voight, T.M. Teslovich, and et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes Nat Genet 44 2012 981 990
36. The CARDIoGRAMplusC4D Consortium P. Deloukas, S. Kanoni, C. Willenborg, and et al. Large-scale association analysis identifies new risk loci for coronary artery disease Nat Genet 45 2012 25 33
37. M. Traylor, M. Farrall, E.G. Holliday, and et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies Lancet Neurol 11 2012 951 962
38. N.L. Smith, J.F. Felix, A.C. Morrison, and et al. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium Circ Cardiovasc Genet 3 2010 256 266
39. A. Kottgen, E. Albrecht, A. Teumer, and et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations Nat Genet 45 2013 145 154
40. T.M. Palmer, D.A. Lawlor, R.M. Harbord, and et al. Using multiple genetic variants as instrumental variables for modifiable risk factors Stat Methods Med Res 21 2012 223 242
41. Johnson T. Efficient calculation for multi-SNP genetic risk scores. Poster presented at: American Society of Human Genetics Annual Meeting; November 7, 2012; San Francisco, California.
42. Z. Dastani, M.F. Hivert, N. Timpson, and et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals PLoS Genet 8 2012 e1002607
43. B.F. Voight MR-predictor: a simulation engine for Mendelian randomization studies Bioinformatics 30 2014 3432 3434
44. V. Bhole, M. de Vera, M.M. Rahman, E. Krishnan, and H. Choi Epidemiology of gout in women: fifty-two-year followup of a prospective cohort Arthritis Rheum 62 2010 1069 1076
45. J. Dziuba, P. Alperin, J. Racketa, and et al. Modeling effects of SGLT-2 inhibitor dapagliflozin treatment versus standard diabetes therapy on cardiovascular and microvascular outcomes Diabetes Obes Metab 16 2014 628 635
46. M.M. Givertz, D.L. Mann, K.L. Lee, and et al. Xanthine oxidase inhibition for hyperuricemic heart failure patients: design and rationale of the EXACT-HF study Circ Heart Fail 6 2013 862 868
47. D.I. Feig, B. Soletsky, and R.J. Johnson Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial JAMA 300 2008 924 932
48. J. George, E. Carr, J. Davies, and et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid Circulation 114 2006 2508 2516
49. A. Kelkar, A. Kuo, and W.H. Frishman Allopurinol as a cardiovascular drug Cardiol Rev 19 2011 265 271
50. S.C. Kim, S. Schneeweiss, N. Choudhry, and et al. Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study Am J Med 128 2015 653.e7 653.e16