Efficacy of two hydrogen peroxide vapour aerial decontamination systems for enhanced disinfection of meticillin-resistant Staphylococcus aureus, Klebsiella pneumoniae and Clostridium difficile in single isolation rooms

Journal of Hospital Infection

Volumn 93, Issue 1, 2016, Pages 70-77

  Ali, S ^a   Muzslay, M ^a   Bruce, M ^a   Jeanes, A ^a   Moore, G ^b   Wilson, A P R ^a  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

Author keywords

Clostridium difficile; Hydrogen peroxide; Infection control; Klebsiella pneumoniae; MRSA; Whole room aerial decontamination

Indexed keywords

HYDROGEN PEROXIDE; AEROSOL; DISINFECTANT AGENT;

ARTICLE; BACTERIAL SPORE; BACTERIUM CONTAMINATION; BACTERIUM IDENTIFICATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISINFECTION SYSTEM; HOSPITAL; HYDROGEN PEROXIDE VAPOR AERIAL DECONTAMINATION SYSTEM; INTERMETHOD COMPARISON; ISOLATION ROOM; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; TURNAROUND TIME; AEROSOL; DISINFECTION; DRUG EFFECTS; HUMAN; PROCEDURES;

AEROSOLS; CLOSTRIDIUM DIFFICILE; DISINFECTANTS; DISINFECTION; HUMANS; HYDROGEN PEROXIDE; KLEBSIELLA PNEUMONIAE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 84959377852     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2016.01.016     Document Type: Article

References (25)

1. Dancer S.J. The role of environmental cleaning in the control of hospital-acquired infection. J Hosp Infect 2009, 73:378-385.
2. Wilson A.P.R., Smyth D., Moore G., et al. The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med 2011, 39:651-658.
3. Steifel U., Cadnum J.L., Eckstein B.C., et al. Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients. Infect Control Hosp Epidemiol 2011, 32:185-187.
4. Neely A.N., Maley M.P. Survival of enterococci and staphylococci on hospital fabrics and plastics. J Clin Microbiol 2000, 38:724-726.
5. Kramer A., Schwebke I., Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 2006, 6:130.
6. Kim K.H., Fekerty R., Batts D.H., et al. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis 1981, 143:42-50.
7. Pittet D., Dharan S., Touvenou S., et al. Bacterial contamination of hands of hospital staff during routine patient care. Arch Intern Med 1999, 159:821-826.
8. Bhalla A., Pultz N.J., Gries D.M., et al. Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalised patients. Infect Control Hosp Epidemiol 2004, 25:164-167.
9. Boyce J.M., Potter-Bynoe G., Chenevert C., King T. Environmental contamination due to methicillin-resistant Staphylococcus aureus: possible infection control implications. Infect Control Hosp Epidemiol 1997, 18:622-627.
10. Hayden M.K., Blom D.W., Lyle E.A., et al. Risk of glove or hand contamination after contact with patients colonized with vancomycin-resistant enterococcus or the colonized patients' environment. Infect Control Hosp Epidemiol 2008, 29:149-154.
11. Huang S.S., Datta R., Platt R. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med 2006, 166:1945-1951.
12. Eyre D.W., Cule M.L., Wilson D.J., et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med 2013, 369:1195-1205.
13. Moore G., Hall T.J., Wilson A.P.R., Gant V. The efficacy of the inorganic copper-based biocide CuWB50 is compromised by hard water. Lett Appl Microbiol 2008, 46:655-660.
14. Ali S., Moore G., Wilson A.P.R. The spread and persistence of Clostridium difficile spores during and after cleaning with sporicidal disinfectants. J Hosp Infect 2011, 79:97-98.
15. McDonnell G., Russell A.D. Antiseptics and disinfectant: activity, action and resistance. Clin Microbiol Rev 1999, 12:147-179.
16. Block S.S. Peroxygen compounds. Disinfection, sterilisation and preservation 1991, 167-181. Lea & Fabiger, Philadelphia, PA. 4th ed.
17. Boyce J.M., Havill N.L., Otter J.A., et al. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in healthcare setting. Infect Control Hosp Epidemiol 2008, 29:723-729.
18. Fu T.Y., Gent P., Kumar V. Efficacy, efficiency and safety aspects of hydrogen peroxide vapour and aerosolized hydrogen peroxide room disinfection systems. J Hosp Infect 2012, 80:199-205.
19. Ali S., Muzslay M., Wilson P. A novel quantitative sampling technique for the detection and monitoring of C. difficile contamination in the clinical environment. J Clin Microbiol 2015, 53:2570-2574.
20. Perez J., Springthorpe S., Sattar S.A. Activity of selected oxidising microbiocides against the spores of Clostridium difficile: relevance to environmental control. Am J Infect Control 2005, 33:320-325.
21. Manian F.A., Griesnauer S., Bryant A. Implementation of hospital-wide enhanced terminal cleaning of targeted patient rooms and its impact on endemic Clostridium difficile infection rates. Am J Infect Control 2013, 41:537-541.
22. Cooper T., O'Leary M., Yezli S., Otter J.A. Impact of environmental decontamination using hydrogen peroxide vapour on the incidence of Clostridium difficile infection in one hospital trust. J Hosp Infect 2011, 78:238-240.
23. Doan L., Forrest H., Fakis A., Craig J., Claxton L., Khare M. Clinical and cost effectiveness of eight disinfection methods for terminal disinfection of hospital isolation rooms contaminated with Clostridium difficile 027. J Hosp Infect 2012, 82:114-121.
24. Pottage T., Macken S., Walker J.T., et al. Meticillin-resistant Staphylococcus aureus is more resistant to vaporized hydrogen peroxide than commercial Geobacillus stearothermophillus biological indicators. J Hosp Infect 2012, 80:41-45.
25. Malik D.J. The elephant in the room: on the routine use of hydrogen peroxide vapour decontamination systems in health care. J Hosp Infect 2013, 83:354-355.