TSH receptor antibody titers measured with a third-generation assay did not reflect the activity of graves’ ophthalmopathy in untreated japanese graves’ disease patients

Endocrine Journal

Volumn 63, Issue 2, 2016, Pages 151-157

  Mukasa, Koji ^a   Noh, Jaeduk Yoshimura ^a   Kouzaki, Ai ^b   Ohye, Hidemi ^a   Kunii, Yo ^a   Watanabe, Natsuko ^a   Yoshihara, Ai ^a   Matsumoto, Masako ^a   Suzuki, Miho ^a   Ito, Koichi ^a  

^a ITO HOSPITAL   (Japan)

^b Olympia Eye Hospital   (Japan)

Author keywords

Clinical activity score; Graves ophthalmopathy; Magnetic resonance imaging; TSH receptor antibody

Indexed keywords

THYROTROPIN RECEPTOR ANTIBODY; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN-BINDING INHIBITORY IMMUNOGLOBULIN;

ADOLESCENT; ADULT; AGED; ANTIBODY TITER; ARTICLE; CHILD; CLINICAL ACTIVITY SCORE; CONTROLLED STUDY; ENDOCRINE OPHTHALMOPATHY; EUTHYROIDISM; FEMALE; HUMAN; HYPERTHYROIDISM; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OPHTHALMOLOGIST; SCORING SYSTEM; BLOOD; BLOOD EXAMINATION; COMPLICATION; DISEASE COURSE; EVALUATION STUDY; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; JAPAN; MIDDLE AGED; PATHOLOGY; PROCEDURES; PROGNOSIS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; DISEASE PROGRESSION; FEMALE; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; HEMATOLOGIC TESTS; HUMANS; IMMUNOGLOBULINS, THYROID-STIMULATING; JAPAN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PROGNOSIS; YOUNG ADULT;

EID: 84959351411     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ15-0137     Document Type: Article

References (23)

1. Bahn RS, Dutton CM, Natt N, Joba W, Spitzweg C, et al. (1998) Thyrotropin receptor expression in Graves’ orbital adipose/connective tissues: potential autoantigen in Graves’ ophthalmopathy. J Clin Endocrinol Metab 83: 998-1002.
2. Crisp M, Starkey KJ, Lane C, Ham J, Ludgate M (2000) Adipogenesis in thyroid eye disease. Invest Ophthalmol Vis Sci 41: 3249-3255.
3. Marino M, Lisi S, Pinchera A, Mazzi B, Latrofa F, et al. (2001) Identification of thyroglobulin in orbital tissues of patients with thyroid-associated ophthalmopathy. Thyroid 11: 177-185.
4. Eckstein AK, Plicht M, Lax H, Neuhauser M, Mann K, et al. (2006) Thyrotropin receptor autoantibodies are independent risk factors for Graves’ ophthalmopathy and help to predict severity and outcome of the disease. J Clin Endocrinol Metab 91: 3464-3470.
5. Costagliola S, Morgenthaler NG, Hoermann R, Badenhoop K, Struck J, et al. (1999) Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves’ disease. J Clin Endocrinol Metab 84: 90-97.
6. Sanders J, Evans M, Premawardhana LD, Depraetere H, Jeffreys J, et al. (2003) Human monoclonal thyroid stimulating autoantibody. Lancet 362: 126-128.
7. Smith BR, Bolton J, Young S, Collyer A, Weeden A, et al. (2004) A new assay for thyrotropin receptor autoantibodies. Thyroid 14: 830-835.
8. Gassner D, Stock W, Golla R, Roth HJ (2009) First automated assay for thyrotropin receptor autoantibodies. Clin Chem Lab Med 47: 1091-1095.
9. Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, et al. (2008) Consensus statement of the European Group on Graves’ orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol 158: 273-285.
10. Acuna OM, Athannassaki I, Paysse EA (2007) Association between thyroid-stimulating immunoglobulin levels and ocular findings in pediatric patients with Graves disease. Trans Am Ophthalmol Soc 105: 146-150.
11. Gerding MN, van der Meer JW, Broenink M, Bakker O, Wiersinga WM, et al. (2000) Association of thyrotrophin receptor antibodies with the clinical features of Graves’ ophthalmopathy. Clin Endocrinol (Oxf) 52: 267-271.
12. Yoshimura Noh J, Miyazaki N, Ito K, Takeda K, Hiramatsu S, et al. (2008) Evaluation of a new rapid and fully automated electrochemiluminescence immunoassay for thyrotropin receptor autoantibodies. Thyroid 18: 1157-1164.
13. Noh JY, Hamada N, Inoue Y, Abe Y, Ito K, et al. (2000) Thyroid-stimulating antibody is related to Graves’ ophthalmopathy, but thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves’ disease. Thyroid 10: 809-813.
14. Subekti I, Boedisantoso A, Moeloek ND, Waspadji S, Mansyur M (2012) Association of TSH receptor antibody, thyroid stimulating antibody, and thyroid blocking antibody with clinical activity score and degree of severity of Graves ophthalmopathy. Acta Med Indones 44: 114-121.
15. Morshed SA, Latif R, Davies TF (2009) Characterization of thyrotropin receptor antibody-induced signaling cascades. Endocrinology 150: 519-529.
16. Wakelkamp IM, Bakker O, Baldeschi L, Wiersinga WM, Prummel MF (2003) TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves’ ophthalmopathy patients. Clin Endocrinol (Oxf) 58: 280-287.
17. Hiromatsu Y, Kojima K, Ishisaka N, Tanaka K, Sato M, et al. (1992) Role of magnetic resonance imaging in thyroid-associated ophthalmopathy: its predictive value for therapeutic outcome of immunosuppressive therapy. Thyroid 2: 299-305.
18. Troelstra A, Rijneveld WJ, Kooijman AC, Houtman WA (1988) Correlation between NMR scans of extraocular muscles and clinical symptoms in Graves’ ophthalmopathy. Doc Ophthalmol 70: 243-249.
19. Kahaly GJ (2001) Imaging in thyroid-associated orbitopathy. Eur J Endocrinol 145: 107-118.
20. Tsai CC, Kau HC, Kao SC, Hsu WM (2006) Exophthalmos of patients with Graves’ disease in Chinese of Taiwan. Eye (Lond) 20: 569-573.
21. Tellez M, Cooper J, Edmonds C (1992) Graves’ ophthalmopathy in relation to cigarette smoking and ethnic origin. Clin Endocrinol (Oxf) 36: 291-294.
22. Khoo DH, Eng PH, Ho SC, Tai ES, Morgenthaler NG, et al. (2000) Graves’ ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels: prevalence, natural history, and thyrotropin receptor antibody levels. Thyroid 10: 1093-1100.
23. Kazuo K, Fujikado T, Ohmi G, Hosohata J, Tano Y (1997) Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients. Br J Ophthalmol 81: 1080-1083.