Enhancement of drug sensitivity by knockdown of HIF-1α in gastric carcinoma cells

Oncology Research

Volumn 23, Issue 3, 2016, Pages 129-136

  Zhao, Qun ^a   Tan, Bi Bo ^a   Li, Yong ^a   Fan, Li Qiao ^a   Yang, Pei Gang ^a   Tian, Yuan ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis related genes; Drug resistance; Drug sensitivity test in vitro; Gastric carcinoma (GC); Hypoxia inducible factor 1a

Indexed keywords

CASPASE 3; CASPASE 8; FLUOROURACIL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXALIPLATIN; PROTEIN BAX; PROTEIN BCL 2; SMALL INTERFERING RNA; SURVIVIN; HIF1A PROTEIN, HUMAN; PLATINUM COMPLEX;

APOPTOSIS; ARTICLE; CANCER CELL LINE; CELL CULTURE; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; MTT ASSAY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STOMACH CARCINOMA; WESTERN BLOTTING; BIOSYNTHESIS; CARCINOMA; CELL HYPOXIA; CELL PROLIFERATION; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PATHOLOGY; STOMACH NEOPLASMS; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ORGANOPLATINUM COMPOUNDS; RNA, SMALL INTERFERING; STOMACH NEOPLASMS;

EID: 84959340136     PISSN: 09650407     EISSN: 15553906     Source Type: Journal    
DOI: 10.3727/096504015X14500513118029     Document Type: Article

References (28)

1. Zhu, C. Y.; Lv, Y. P.; Yan, D. F.; Gao, F. L. Knockdown of MDR1 increases the sensitivity to adriamycin in drug resistant gastric cancer cells. Asian Pac. J. Cancer Prev. 14:6757-6760;2013.
2. Yan, L. H.; Wang, X. T.; Yang, J.; Kong, F. B.; Lian, C.; Wei, W. Y.; Luo, W.; Xie, Y. B.; Xiao, Q. Reversal of multidrug resistance in gastric cancer cells by E2F-1 downregulation in vitro and in vivo. J. Cell Biochem. 115:34-41;2014.
3. Kang, J.; Zhao, G.; Lin, T.; Tang, S.; Xu, G.; Hu, S.; Bi, Q.; Guo, C.; Sun, L.; Han, S.; Xu, Q.; Nie, Y.; Wang, B.; Liang, S.; Ding, J.; Wu, K. A peptide derived from phage display library exhibits anti-tumor activity by targeting GRP78 in gastric cancer multidrug resistance cells. Cancer Lett. 339:247-259;2013.
4. Wang, Y.; Liu, L.; Liu, X.; Zhang, H.; Liu, J.; Feng, B.; Shang, Y.; Zhou, L.; Wu, K.; Nie, Y.; Zhang, H.; Fan, D. Shugoshin1 enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl-2, and Bax genes. Tumour Biol. 34:2205-2214;2013.
5. Xie, X.; Tang, B.; Zhou, J.; Gao, Q.; Zhang, P. Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. Oncol. Rep. 30:773-782;2013.
6. Zhang, K. G.; Qin, C. Y.; Wang, H. Q.; Wang, J. X.; Wang, Q. M. The effect of TRAIL on the expression of multidrug resistant genes MDR1, LRP and GST-p in drug-resistant gastric cancer cell SGC7901/VCR. Hepatogastroenterology 59:2672-2676;2012.
7. Li, Y.; Tan, B. B.; Zhao, Q.; Fan, L. Q.; Liu, Y.; Hao, Y. J.; Zhao, X. F. Tumor chemosensitivity is correlated with expression of multidrug resistance associated factors in variously differentiated gastric carcinoma tissues. Hepatogastroenterology 60:213-216;2013.
8. Gazzaniga, P.; Gradilone, A.; Petracca, A.; Nicolazzo, C.; Raimondi, C.; Iacovelli, R.; Naso, G.; Cortesi, E. Molecular markers in circulating tumour cells from metastatic colorectal cancer patients. J. Cell. Mol. Med. 14:2073-2077;2010.
9. Liu, L.; Sun, L.; Zhang, H.; Li, Z.; Ning, X.; Shi, Y.; Guo, C.; Han, S.; Wu, K.; Fan, D. Hypoxia-mediated up-regulation of MGr1-Ag/37LRP in gastric cancers occurs via hypoxia-inducible-factor 1-dependent mechanism and contributes to drug resistance. Int. J. Cancer 124:1707-1715;2009.
10. Chen, M. H.; Ren, Q. X.; Yang, W. F.; Chen, X. L.; Lu, C.; Sun, J. Influences of HIF-la on Bax/Bcl-2 and VEGF expressions in rats with spinal cord injury. Int. J. Clin. Exp. Pathol. 6:2312-2322;2013.
11. Yashiro, M.; Chung, Y. S.; Nishimura, S.; Inoue, T.; Sowa, M. Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice. Clin. Exp. Metastasis. 14:43-54;1996.
12. Zhao, Q.; Zhang, H.; Li, Y.; Liu, J.; Hu, X.; Fan, L. Antitumor effects of CIK combined with oxaliplatin in human oxaliplatin-resistant gastric cancer cells in vivo and in vitro. J. Exp. Clin. Cancer Res. 29:118;2010.
13. Zhao, Q.; Li, Y,; Tan, B. B.; Fan, L. Q.; Wang, D.; Yang, P. G. Effect of hypoxia inducible factor-la on multidrug resistance of gastric cancer cells and mechanism. Chinese J. Exp. Surg. 29:2472-2474;2012.
14. Xie, Z.; Cao, L.; Zhang, J. miR-21 modulates paclitaxel sensitivity and hypoxia-inducible factor-1a expression in human ovarian cancer cells. Oncol. Lett. 6:795-800;2013.
15. Li, D. W.; Dong, P.; Wang, F.; Chen, X. W.; Xu, C. Z.; Zhou, L. Hypoxia induced multidrug resistance of laryngeal cancer cells via hypoxia-inducible factor-1a. Asian. Pac. J. Cancer Prev. 14:4853-4858;2013.
16. Li, S. Z.; Li, K.; Zhang, J. H.; Dong, Z. The effect of quercetin on doxorubicin cytotoxicity in human breast cancer cells. Anticancer Agent. Med. Chem. 13:352-355;2013.
17. Ye, M. X.; Zhao, Y. L.; Li, Y.; Miao, Q.; Li, Z. K.; Ren, X. L.; Song, L. Q.; Yin, H.; Zhang, J. Curcumin reverses cisplatin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1a and caspase-3 mechanisms. Phytomedicine 19:779-787;2012.
18. Chen, M.; Huang, S. L.; Zhang, X. Q.; Zhang, B.; Zhu, H.; Yang, V. W.; Zou, X. P. Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1a/P-gp and MRP1 signaling pathway in vitro and in vivo. J. Cell Biochem. 113:2474-2487;2012.
19. Zhou, Y.; Tozzi, F.; Chen, J.; Fan, F.; Xia, L.; Wang, J.; Gao, G.; Zhang, A.; Xia, X.; Brasher, H.; Widger, W.; Ellis, L. M.; Weihua, Z. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res. 72:304-314;2012.
20. Zhao, P.; Zhang, Y.; Sun, M.; He, Y. Reversion of multidrug resistance in human glioma by RNA interference. Neurol. Res. 30:562-566;2008.
21. Zhao, Q.; Li, Y.; Tian, Y.; Chen, Y. N.; Tan, B. B.; Zhao, X. F.; Jiao, Z. K.; Zhang, Z. D.; Chang, S. L. Histological complete response after neoadjuvant XELOX in advanced gastric carcinoma. Hepatogastroenterology 60:638-640;2013.
22. Chen, S.; Feng, X.; Li, Y.; Yuan, X.; Zhou, Z.; Chen, Y. Efficacy and safety of XELOX and FOLFOX6 adjuvant chemotherapy following radical total gastrectomy. Oncol. Lett. 3:781-786;2012.
23. Kim, G. M.; Jeung, H. C.; Rha, S. Y.; Kim, H. S.; Jung, I.; Nam, B. H.; Lee, K. H.; Chung, H. C. A randomized phase II trial of S-1-oxaliplatin versus capecitabine-oxaliplatin in advanced gastric cancer. Eur. J. Cancer 48:518-526;2012.
24. Dong, H.; Liu, G.; Jiang, B.; Guo, J.; Tao, G.; Yiu, W.; Zhou, J.; Li, G. Overexpression of the Survivin gene in SGC7901 cell resistance to cisplatin. Oncol. Lett. 8:1953-1956;2014.
25. Khan, Z.; Khan, N.; Varma, A. K.; Tiwari, R. P.; Mouhamad, S.; Prasad, G. B.; Bisen, P. Oxaliplatin-mediated inhibition of survivin increases sensitivity of head and neck squamous cell carcinoma cell lines to paclitaxel. Curr. Cancer Drug Targets 10:660-669;2010.
26. Wittkopf, N.; Günther, C.; Martini, E.; He, G.; Amann, K.; He, Y. W.; Schuchmann, M.; Neurath, M. F.; Becker, C. Cellular FLICE-like inhibitory protein secures intestinal epithelial cell survival and immune homeostasis by regulating caspase-8. Gastroenterology 145:1369-1379;2013.
27. Sikdar, S.; Mukherjee, A.; Ghosh, S.; Khuda-Bukhsh, A. R. Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cellproliferation in lung cancer, in vitro and in vivo. Environ. Toxicol. Pharmacol. 37:300-314;2013.
28. Kontos, C. K.; Christodoulou, M. I.; Scorilas, A. Apoptosisrelated BCL2-family members: Key players in chemotherapy. Anticancer Agents Med. Chem. 14:353-374;2014.