CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia

Blood

Volumn 127, Issue 6, 2016, Pages 735-738

  Guo, Li ^a,b   Kapur, Rick ^a,c   Aslam, Rukshana ^a   Speck, Edwin R ^a   Zufferey, Anne ^a   Zhao, Yajing ^a   Kim, Michael ^a   Lazarus, Alan H ^a,d   Ni, Heyu ^a,d   Semple, John W ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CANADIAN BLOOD SERVICES   (Canada)

^d Department of Medicine ^*  (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; INTERLEUKIN 2; RITUXIMAB; TRANSCRIPTION FACTOR FOXP3; CD20 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; HUMORAL IMMUNE DEFICIENCY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SCID MOUSE; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; THROMBOCYTE COUNT; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; C57BL MOUSE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE DEPLETION; METABOLISM; PATHOLOGY; PROCEDURES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

ANIMALS; ANTIGENS, CD20; B-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; INTEGRIN BETA3; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC;

EID: 84959323543     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-06-655126     Document Type: Article

References (25)

1. McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol. 2013; 163(1):10-23.
2. Harrington WJ, Minnich V, Hollingsworth JW, Moore CV. Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura. J Lab Clin Med. 1951;38(1):1-10.
3. Brighton TA, Evans S, Castaldi PA, Chesterman CN, Chong BH. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood. 1996;88(1):194-201.
4. Olsson B, Andersson PO, Jernas M, et al. T-cellmediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med. 2003;9(9):1123-1124.
5. Li S, Wang L, Zhao C, Li L, Peng J, Hou M. CD81 T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura. Br J Haematol. 2007; 139(4):605-611.
6. Stasi R, Cooper N, Del Poeta G, et al. Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood. 2008;112(4):1147-1150.
7. Liu B, Zhao H, Poon MC, et al. Abnormality of CD4(1)CD25(1) regulatory T cells in idiopathic thrombocytopenic purpura. Eur J Haematol. 2007; 78(2):139-143.
8. Sakakura M, Wada H, Tawara I, et al. Reduced Cd41Cd251 T cells in patients with idiopathic thrombocytopenic purpura. Thromb Res. 2007; 120(2):187-193.
9. Stasi R, Pagano A, Stipa E, Amadori S. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood. 2001;98(4): 952-957.
10. Lund FE. Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol. 2008; 20(3):332-338.
11. Lund FE, Randall TD. Effector and regulatory B cells: modulators of CD41 T cell immunity. Nat Rev Immunol. 2010;10(4):236-247.
12. Cooper N, Stasi R, Cunningham-Rundles S, Cesarman E, McFarland JG, Bussel JB. Platelet-associated antibodies, cellular immunity and FCGR3a genotype influence the response to rituximab in immune thrombocytopenia. Br J Haematol. 2012; 158(4):539-547.
13. Stasi R, Del Poeta G, Stipa E, et al. Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood. 2007; 110(8):2924-2930.
14. Chow L, Aslam R, Speck ER, et al. A murine model of severe immune thrombocytopenia is induced by antibody- and CD81 T cell-mediated responses that are differentially sensitive to therapy. Blood. 2010;115(6):1247-1253.
15. Uchida J, Lee Y, Hasegawa M, et al. Mouse CD20 expression and function. Int Immunol. 2004;16(1): 119-129.
16. Uchida J, Hamaguchi Y, Oliver JA, et al. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med. 2004;199(12): 1659-1669.
17. Yu S, Ellis JS, Dunn R, Kehry MR, Braley- Mullen H. Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults. Int Immunol. 2012;24(4): 233-242.
18. Shen H, Whitmire JK, Fan X, Shedlock DJ, Kaech SM, Ahmed R. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. J Immunol. 2003;170(3): 1443-1451.
19. Brodie GM, Wallberg M, Santamaria P, Wong FS, Green EA. B-cells promote intra-islet CD81 cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes. 2008;57(4):909-917.
20. Thomsen AR, Johansen J, Marker O, Christensen JP. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice. J Immunol. 1996;157(7):3074-3080.
21. Audia S, Samson M, Mahevas M, et al. Preferential splenic CD8(1) T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia. Blood. 2013;122(14): 2477-2486.
22. Lee-Chang C, Bodogai M, Moritoh K, et al. Accumulation of 4-1BBL1 B cells in the elderly induces the generation of granzyme-B1 CD81 T cells with potential antitumor activity. Blood. 2014;124(9):1450-1459.
23. Bodogai M, Lee Chang C, Wejksza K, et al. Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L. Cancer Res. 2013;73(7): 2127-2138 .
24. Laurent C, Muller S, Do C, et al. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: A 3-D tissue-imaging study. Blood. 2011;118(20): 5371-5379.
25. Xiu Y, Wong CP, Bouaziz JD, et al. Blymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol. 2008;180(5): 2863-2875.