Filaggrin genotype and skin diseases independent of atopic dermatitis in childhood

Pediatric Allergy and Immunology

Volumn 27, Issue 2, 2016, Pages 162-168

  Bager, Peter ^a   Wohlfahrt, Jan ^a   Thyssen, Jacob Pontoppidan ^b   Melbye, Mads ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Atopic dermatitis; Dry skin; Filaggrin; Fungus; Genotype; Warts

Indexed keywords

DNA; FILAGGRIN; INTERMEDIATE FILAMENT PROTEIN;

ADOLESCENT; ADULT; AGE; ARTICLE; ATOPIC DERMATITIS; CHILD; CHILDHOOD DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DERMATOMYCOSIS; DNA EXTRACTION; DRY SKIN; FOLLOW UP; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPING TECHNIQUE; HUMAN; INDEPENDENT VARIABLE; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; NEWBORN; PATIENT REFERRAL; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RASH; REGISTER; RISK REDUCTION; SKIN ALLERGY; SKIN DISEASE; URTICARIA; VERRUCA VULGARIS; CASE CONTROL STUDY; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; MALE; MUTATION; PRESCHOOL CHILD;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DERMATITIS, ATOPIC; DNA MUTATIONAL ANALYSIS; EXANTHEMA; FEMALE; FOLLOW-UP STUDIES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MALE; MUTATION; REGISTRIES; URTICARIA;

EID: 84959320406     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12511     Document Type: Article

References (31)

1. Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011: 365: 1315-27.
2. Brown SJ, McLean WH. One remarkable molecule: filaggrin. J Invest Dermatol 2012: 132: 751-62.
3. Benedetto AD, Qualia CM, Baroody FM, Beck LA. Filaggrin expression in oral, nasal, and esophageal mucosa. J Invest Dermatol 2008: 128: 1594-7.
4. Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006: 38: 441-6.
5. Smith FJ, Irvine AD, Terron-Kwiatkowski A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet 2006: 38: 337-42.
6. Bohme M, Soderhall C, Kull I, Bergstrom A, van Hage M, Wahlgren CF. Filaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization. J Allergy Clin Immunol 2012: 129: 1153-5.
7. Cai SC, Chen H, Koh WP, et al. Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis. Br J Dermatol 2012: 166: 200-3.
8. Gao PS, Rafaels NM, Hand T, et al. Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum. J Allergy Clin Immunol 2009: 124: 507-13, 513.
9. Bin L, Kim BE, Brauweiler A, et al. Staphylococcus aureus alpha-toxin modulates skin host response to viral infection. J Allergy Clin Immunol 2012: 130: 683-91.
10. Reed JL, Scott DE, Bray M. Eczema vaccinatum. Clin Infect Dis 2012: 54: 832-40.
11. Faergemann J. Atopic dermatitis and fungi. Clin Microbiol Rev 2002: 15: 545-63.
12. Alleman BW, Myking S, Ryckman KK, et al. No observed association for mitochondrial SNPs with preterm delivery and related outcomes. Pediatr Res 2012: 72: 539-44.
13. Myking S, Boyd HA, Myhre R, et al. X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a Danish/Norwegian genome-wide association study. PLoS ONE 2013: 8: e61781.
14. Kim J, Stirling KJ, Cooper ME, et al. Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study. BMC Med Genet 2013: 14: 77.
15. Ryckman KK, Feenstra B, Shaffer JR, et al. Replication of a genome-wide association study of birth weight in preterm neonates. J Pediatr 2012: 160: 19-24.
16. Pedersen CB, Gotzsche H, Moller JO, Mortensen PB. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 2006: 53: 441-9.
17. Harpsoe MC, Basit S, Bager P, et al. Maternal obesity, gestational weight gain, and risk of asthma and atopic disease in offspring: a study within the Danish National Birth Cohort. J Allergy Clin Immunol 2013: 131: 1033-40.
18. Benn CS, Benfeldt E, Andersen PK, Olesen AB, Melbye M, Bjorksten B. Atopic dermatitis in young children: diagnostic criteria for use in epidemiological studies based on telephone interviews. Acta Derm Venereol 2003: 83: 347-50.
19. Andersen JS, Olivarius NF, Krasnik A. The Danish National Health Service Register. Scand J Public Health 2011: 39(7 Suppl): 34-7.
20. Rodriguez E, Baurecht H, Herberich E, et al. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009: 123: 1361-70.
21. Thyssen JP, Carlsen BC, Bisgaard H, et al. Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible. J Eur Acad Dermatol Venereol 2012: 26: 386-9.
22. Barker JN, Palmer CN, Zhao Y, et al. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol 2007: 127: 564-7.
23. Weidinger S, Rodriguez E, Stahl C, et al. Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J Invest Dermatol 2007: 127: 724-6.
24. Brown SJ, Relton CL, Liao H, et al. Filaggrin null mutations and childhood atopic eczema: a population-based case-control study. J Allergy Clin Immunol 2008: 121: 940-6.
25. Oyoshi MK, Murphy GF, Geha RS. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol 2009: 124: 485-93, 493.
26. Sudbery PE. Growth of Candida albicans hyphae. Nat Rev Microbiol 2011: 9: 737-48.
27. Agostini G, Geti V, Difonzo EM, Giannotti B. Dermatophyte infection in ichthyosis vulgaris. Mycoses 1992: 35: 197-9.
28. Beltrani VS. Warts and the atopic. Arch Dermatol 1994: 130: 388-9.
29. Williams H, Pottier A, Strachan D. Are viral warts seen more commonly in children with eczema? Arch Dermatol 1993: 129: 717-20.
30. Henderson J, Northstone K, Lee SP, et al. The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol 2008: 121: 872-7.
31. Horimukai K, Morita K, Narita M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol 2014: 134: 824-30.