Evidence for constrained positive selection of cancer mutations in normal skin is lacking

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 9, 2016, Pages E1130-E1131

  Simons, Benjamin D ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR;

CANCER GENETICS; CARCINOGENESIS; EPIDERMIS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SELECTION; HOUSEKEEPING GENE; HUMAN; LETTER; NEOPLASM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SKIN; TUMOR GENE; CELL TRANSFORMATION; GENETICS; PATHOLOGY; STEM CELL;

CELL TRANSFORMATION, NEOPLASTIC; EPIDERMIS; HUMANS; NEOPLASMS; STEM CELLS;

EID: 84959292347     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1601045113     Document Type: Letter

References (7)

1. Martincorena I, Jones PH, Campbell PJ (2016) Constrained positive selection on cancer mutations in normal skin. Proc Natl Acad Sci USA 113:E1128-E1129.
2. Martincorena I, et al. (2015) Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science 348(6237):880-886.
3. Simons BD (2016) Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis. Proc Natl Acad Sci USA 113(1):128-133.
4. Clayton E, et al. (2007) A single type of progenitor cell maintains normal epidermis. Nature 446(7132):185-189.
5. Klein AM, Simons BD (2011) Universal patterns of stem cell fate in cycling adult tissues. Development 138(15):3103-3111.
6. Zhang W, Remenyik E, Zelterman D, Brash DE, Wikonkal NM (2001) Escaping the stem cell compartment: Sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc Natl Acad Sci USA 98(24):13948-13953.
7. Alcolea MP, et al. (2014) Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol 16(6):615-622.