White matter microstructure of the uncinate fasciculus is associated with subthreshold posttraumatic stress disorder symptoms and fear potentiated startle during early extinction in recently deployed Service Members

Neuroscience Letters

Volumn 618, Issue , 2016, Pages 66-71

  Costanzo, Michelle E ^a,b,c   Jovanovic, Tanja ^d   Pham, Dzung ^b   Leaman, Suzanne ^a   Highland, Krista B ^a,b,c   Norrholm, Seth Davin ^d,e   Roy, Michael J ^a,c  

^a Uniformed Services University of the Health Sciences   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Combat veterans; Diffusion tensor imaging; Fear potentiated startle; Subthreshold PTSD

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; DIFFUSION TENSOR IMAGING; DISEASE SEVERITY; ELECTROMYOGRAPHY; FEAR-POTENTIATED STARTLE TEST; FEMALE; HUMAN; MALE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SOLDIER; STARTLE REFLEX; SYMPTOM; UNCINATE FASCICULUS; WHITE MATTER; ECHOGRAPHY; FEAR; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOLOGY; REINFORCEMENT; VETERAN; WAR EXPOSURE;

ADULT; DIFFUSION TENSOR IMAGING; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; HUMANS; MALE; MIDDLE AGED; REFLEX, STARTLE; STRESS DISORDERS, POST-TRAUMATIC; VETERANS; WAR EXPOSURE; WHITE MATTER;

EID: 84959272727     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.02.041     Document Type: Article

References (26)

1. Fulton J.J., et al. The prevalence of posttraumatic stress disorder in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans: a meta-analysis. J. Anxiety Disord. 2015, 31:98-107.
2. Mylle J., Maes M. Partial posttraumatic stress disorder revisited. J. Affect. Disord. 2004, 78(1):37-48.
3. Rothbaum B.O., et al. Early intervention may prevent the development of posttraumatic stress disorder: a randomized pilot civilian study with modified prolonged exposure. Biol. Psychiatry 2012, 72(11):957-963.
4. Jovanovic T., Norrholm S.D. Neural mechanisms of impaired fear inhibition in posttraumatic stress disorder. Front. Behav. Neurosci. 2011, 5:44.
5. Fani N., et al. Fear-potentiated startle during extinction is associated with white matter microstructure and functional connectivity. Cortex 2015, 64:249-259.
6. Phan K.L., et al. Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol. Psychiatry 2009, 66(7):691-694.
7. Tromp D.P., et al. Reduced structural connectivity of a major frontolimbic pathway in generalized anxiety disorder. Arch. Gen. Psychiatry 2012, 69(9):925-934.
8. Norrholm S.D., et al. Fear extinction in traumatized civilians with posttraumatic stress disorder: relation to symptom severity. Biol. Psychiatry 2011, 69(6):556-563.
9. Weathers F.W., Keane T.M., Davidson J.R. Clinician-administered PTSD scale: a review of the first ten years of research. Depress. Anxiety 2001, 13(3):132-156.
10. Forbes D., Creamer M., Biddle D. The validity of the PTSD checklist as a measure of symptomatic change in combat-related PTSD. Behav. Res. Ther. 2001, 39(8):977-986.
11. Spitzer R.L., Kroenke K., Williams J.B. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study: Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 1999, 282(18):1737-1744.
12. Norrholm S.D., et al. Fear load: the psychophysiological over-expression of fear as an intermediate phenotype associated with trauma reactions. Int. J. Psychophysiol. 2015, 98(2 pt 2):270-275.
13. Landman B.A., et al. System for integrated neuroimaging analysis and processing of structure. Neuroinformatics 2013, 11(1):91-103.
14. Bazin P.L., et al. Direct segmentation of the major white matter tracts in diffusion tensor images. Neuroimage 2011, 58(2):458-468.
15. Foa E.B., Riggs D.S., Gershuny B.S. Arousal, numbing, and intrusion: symptom structure of PTSD following assault. Am. J. Psychiatry 1995, 152(1):116-120.
16. Litz B.T., et al. Predictors of emotional numbing in posttraumatic stress disorder. J. Trauma. Stress 1997, 10(4):607-618.
17. Stam R. PTSD and stress sensitisation: a tale of brain and body part 1: human studies. Neurosci. Biobehav. Rev. 2007, 31(4):530-557.
18. Weems C.F., et al. A prospective test of the association between hyperarousal and emotional numbing in youth with a history of traumatic stress. J. Clin. Child Adolesc. Psychol. 2003, 32(1):166-171.
19. Schell T.L., Marshall G.N., Jaycox L.H. All symptoms are not created equal: the prominent role of hyperarousal in the natural course of posttraumatic psychological distress. J. Abnorm. Psychol. 2004, 113(2):189-197.
20. Von Der Heide R.J., et al. Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis. Brain 2013, 136(Pt 6):1692-1707.
21. McTeague L.M., et al. Aversive imagery in posttraumatic stress disorder: trauma recurrence, comorbidity, and physiological reactivity. Biol. Psychiatry 2010, 67(4):346-356.
22. Karatsoreos I.N., McEwen B.S. Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn. Sci. 2011, 15(12):576-584.
23. Costanzo M.E., et al. Connecting combat-related mild traumatic brain injury with posttraumatic stress disorder symptoms through brain imaging. Neurosci. Lett. 2014, 577C:11-15.
24. Fani N., et al. White matter integrity in highly traumatized adults with and without post-traumatic stress disorder. Neuropsychopharmacology 2012, 37(12):2740-2746.
25. Daniels J.K., et al. White matter integrity and its relationship to PTSD and childhood trauma-a systematic review and meta-analysis. Depress. Anxiety 2013, 30(3):207-216.
26. Wu G., et al. Understanding resilience. Front. Behav. Neurosci. 2013, 7:10.