Benzodiazepine use and risk of incident dementia or cognitive decline: Prospective population based study

BMJ (Online)

Volumn 352, Issue , 2016, Pages

  Gray, Shelly L ^a   Dublin, Sascha ^b   Yu, Onchee ^b   Walker, Rod ^b   Anderson, Melissa ^b   Hubbard, Rebecca A ^c   Crane, Paul K ^d   Larson, Eric B ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CENTER FOR HEALTH STUDIES   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE; CHLORDIAZEPOXIDE; CLONAZEPAM; CLORAZEPATE; DIAZEPAM; ESZOPICLONE; FLURAZEPAM; LORAZEPAM; OXAZEPAM; TEMAZEPAM; TRIAZOLAM; ZALEPLON; ZOLPIDEM; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; BENZODIAZEPINE DERIVATIVE;

AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROVASCULAR ACCIDENT; COGNITIVE ABILITIES SCREENING INSTRUMENT; COGNITIVE DEFECT; COGNITIVE FUNCTION TEST; COHORT ANALYSIS; CONTROLLED STUDY; DEMENTIA; DEPRESSION; DRUG EXPOSURE; FEMALE; FOLLOW UP; HIGH RISK POPULATION; HUMAN; HYPERTENSION; INCIDENCE; INTEGRATED HEALTH CARE SYSTEM; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRESCRIPTION; PRIORITY JOURNAL; PRODROMAL SYMPTOM; PROSPECTIVE STUDY; UNITED STATES; CHEMICALLY INDUCED; COGNITION DISORDERS; HEALTH SURVEY; LONGITUDINAL STUDY; RISK FACTOR; WASHINGTON;

AGED; ALZHEIMER DISEASE; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BENZODIAZEPINES; COGNITION DISORDERS; DEMENTIA; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; POPULATION SURVEILLANCE; PROSPECTIVE STUDIES; RISK FACTORS; WASHINGTON;

EID: 84959259121     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.i90     Document Type: Article

References (36)

1. Olfson M, King M, Schoenbaum M. Benzodiazepine use in the United States. JAMA Psychiatry 2015;72:136-42. doi:10.1001/jamapsychiatry.2014.1763.
2. Koyama A, Steinman M, Ensrud K, Hillier TA, Yaffe K. Ten-year trajectory of potentially inappropriate medications in very old women: importance of cognitive status. J Am Geriatr Soc 2013;61:258-63. doi:10.1111/jgs.12093.
3. Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK. Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med 2009;37:177-83. doi:10.1097/CCM.0b013e318192fcf9.
4. American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616-31. doi:10.1111/j.1532-5415.2012.03923.x.
5. Tannenbaum C, Paquette A, Hilmer S, Holroyd-Leduc J, Carnahan R. A systematic review of amnestic and non-amnestic mild cognitive impairment induced by anticholinergic, antihistamine, GABAergic and opioid drugs. Drugs Aging 2012;29:639-58.
6. Mura T, Proust-Lima C, Akbaraly T, et al. Chronic use of benzodiazepines and latent cognitive decline in the elderly: results from the Three-city study. Eur Neuropsychopharmacol 2013;23:212-23. doi:10.1016/j.euroneuro.2012.05.004.
7. Verdoux H, Lagnaoui R, Begaud B. Is benzodiazepine use a risk factor for cognitive decline and dementia? A literature review of epidemiological studies. Psychol Med 2005;35:307-15. doi:10.1017/S0033291704003897.
8. Billioti de Gage S, Bégaud B, Bazin F, et al. Benzodiazepine use and risk of dementia: prospective population based study. BMJ 2012;345:e6231. doi:10.1136/bmj.e6231.
9. Billioti de Gage S, Moride Y, Ducruet T, et al. Benzodiazepine use and risk of Alzheimer's disease: case-control study. BMJ 2014;349:g5205. doi:10.1136/bmj.g5205.
10. Lagnaoui R, Bégaud B, Moore N, et al. Benzodiazepine use and risk of dementia: a nested case-control study. J Clin Epidemiol 2002;55:314-8. doi:10.1016/S0895-4356(01)00453-X.
11. Wu CS, Ting TT, Wang SC, Chang IS, Lin KM. Effect of benzodiazepine discontinuation on dementia risk. Am J Geriatr Psychiatry 2011;19:151-9. doi:10.1097/JGP.0b013e3181e049ca.
12. Wu CS, Wang SC, Chang IS, Lin KM. The association between dementia and long-term use of benzodiazepine in the elderly: nested case-control study using claims data. Am J Geriatr Psychiatry 2009;17:614-20. doi:10.1097/JGP.0b013e3181a65210.
13. Gallacher J, Elwood P, Pickering J, Bayer A, Fish M, Ben-Shlomo Y. Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS). J Epidemiol Community Health 2012;66:869-73. doi:10.1136/jech-2011-200314.
14. Imfeld P, Bodmer M, Jick SS, Meier CR. Benzodiazepine Use and risk of developing Alzheimer's Disease or vascular dementia: A case-control analysis. Drug Saf 2015;38:909-19. doi:10.1007/s40264-015-0319-3.
15. Amieva H, Le Goff M, Millet X, et al. Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Ann Neurol 2008;64:492-8. doi:10.1002/ana.21509.
16. Stella F, Radanovic M, Balthazar ML, Canineu PR, de Souza LC, Forlenza OV. Neuropsychiatric symptoms in the prodromal stages of dementia. Curr Opin Psychiatry 2014;27:230-5. doi:10.1097/YCO.0000000000000050.
17. Richard E, Reitz C, Honig LH, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol 2013;70:374-82.
18. Kukull WA, Higdon R, Bowen JD, et al. Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol 2002;59:1737-46. doi:10.1001/archneur.59.11.1737.
19. Teng EL, Hasegawa K, Homma A, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr 1994;6:45-58, discussion 62. doi:10.1017/S1041610294001602.
20. Diagnostic and Statistical Manual of Mental Disorders.4th ed. American Psychiatric Association, 1994.
21. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44. doi:10.1212/WNL.34.7.939.
22. Crane PK, Narasimhalu K, Gibbons LE, et al. Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline. J Clin Epidemiol 2008;61:1018-27.e9. doi:10.1016/j.jclinepi.2007.11.011.
23. Ehlenbach WJ, Hough CL, Crane PK, et al. Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA 2010;303:763-70. doi:10.1001/jama.2010.167.
24. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook.15th ed. Lexicomp, 2010.
25. Gray SL, Anderson ML, Dublin S, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015;175:401-7. doi:10.1001/jamainternmed.2014.7663.
26. Gray SL, LaCroix AZ, Blough D, Wagner EH, Koepsell TD, Buchner D. Is the use of benzodiazepines associated with incident disability?J Am Geriatr Soc 2002;50:1012-8. doi:10.1046/j.1532-5415.2002.50254.x.
27. Hanlon JT, Boudreau RM, Roumani YF, et al. Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. J Gerontol A Biol Sci Med Sci 2009;64:492-8. doi:10.1093/gerona/gln043.
28. Tamim H, Monfared AA, LeLorier J. Application of lag-time into exposure definitions to control for protopathic bias. Pharmacoepidemiol Drug Saf 2007;16:250-8. doi:10.1002/pds.1360.
29. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. 2014. http://www.nhlbi.nih.gov/files/docs/guidelines/obesity-guidelines-archive.pdf
30. Larson EB, Wang L, Bowen JD, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 2006;144:73-81. doi:10.7326/0003-4819-144-2-200601170-00004.
31. Andresen EM, Malmgren JA, Carter WB, Patrick DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med 1994;10:77-84.
32. Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986;42:121-30. doi:10.2307/2531248.
33. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-9. doi:10.1016/0895-4356(92)90133-8.
34. Johansson L, Guo X, Waern M, et al. Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain 2010;133:2217-24. doi:10.1093/brain/awq116.
35. Skogen JC, Bergh S, Stewart R, Knudsen AK, Bjerkeset O. Midlife mental distress and risk for dementia up to 27 years later: the Nord-Trøndelag Health Study (HUNT) in linkage with a dementia registry in Norway. BMC Geriatr 2015;15:23. doi:10.1186/s12877-015-0020-5.
36. Spira AP, Chen-Edinboro LP, Wu MN, Yaffe K. Impact of sleep on the risk of cognitive decline and dementia. Curr Opin Psychiatry 2014;27:478-83. doi:10.1097/YCO.0000000000000106.