Chronic use of benzodiazepines and latent cognitive decline in the elderly: Results from the Three-city study

European Neuropsychopharmacology

Volumn 23, Issue 3, 2013, Pages 212-223

  Mura, Thibault ^a,b,c   Proust Lima, Cécile ^d,e   Akbaraly, Tasnime ^a,b,f   Amieva, Hélène ^d,e   Tzourio, Christophe ^c   Chevassus, Hugues ^b,c   Picot, Marie Christine ^b,c   Jacqumin Gadda, Hélène ^d,e   Berr, Claudine ^a,b  

^a INSERM U1061   (France)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

^c INSERM   (France)

^d INSERM U657   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Benzodiazepines; Cognitive decline; Cognitive impairment; Latent process; Longitudinal study

Indexed keywords

BENZODIAZEPINE DERIVATIVE;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DEPRESSION; FEMALE; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INSOMNIA; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NEUROPSYCHOLOGICAL TEST; NONLINEAR REGRESSION ANALYSIS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; TOBACCO;

AGED; AGED, 80 AND OVER; BENZODIAZEPINES; CASE-CONTROL STUDIES; COGNITION; COGNITION DISORDERS; COHORT STUDIES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; NEUROPSYCHOLOGICAL TESTS;

EID: 84875243986     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2012.05.004     Document Type: Article

References (40)

1. Barker M.J., Greenwood K.M., Jackson M., Crowe S.F. Persistence of cognitive effects after withdrawal from long-term benzodiazepine use: a meta-analysis. Arch. Clin. Neuropsychol. 2004, 19(3):437-454.
2. Benton, A., 1965. Manuel pour l'application du test de rétention visuelle. Applications cliniques et expérimentales (in French), Centre de Psychologie appliquée. Paris, France.
3. Bierman E.J., Comijs H.C., Gundy C.M., Sonnenberg C., Jonker C., Beekman A.T. The effect of chronic benzodiazepine use on cognitive functioning in older persons: good, bad or indifferent?. Int. J. Geriatr. Psychiatry 2007, 22(12):1194-1200.
4. Buffett-Jerrott S.E., Stewart S.H. Cognitive and sedative effects of benzodiazepine use. Curr. Pharm. Des. 2002, 8(1):45-58.
5. Collie A., Maruff P., Darby D.G., McStephen M. The effects of practice on the cognitive test performance of neurologically normal individuals assessed at brief test-retest intervals. J. Int. Neuropsychol. Soc. 2003, 9(3):419-428.
6. Cumming R.G. Epidemiology of medication-related falls and fractures in the elderly. Drugs Aging 1998, 12(1):43-53.
7. Curran H.V. Benzodiazepines, memory and mood: a review. Psychopharmacology (Berlin) 1991, 105(1):1-8.
8. Dealberto M.J., McAvay G.J., Seeman T., Berkman L. Psychotropic drug use and cognitive decline among older men and women. Int. J. Geriatr. Psychiatry 1997, 12(5):567-574.
9. Fastbom J., Forsell Y., Winblad B. Benzodiazepines may have protective effects against Alzheimer disease. Alzheimer Dis. Assoc. Disord. 1998, 12(1):14-17.
10. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12(3):189-198.
11. Food and Drug Administration Prescribing of minor tranquilizaers. FDA Drug Bull. 1980, 2-3.
12. Führer R., Rouillon F. La version française de l'échelle CES-D (Center for Epidemiologic Studies Depression Scale). Psychiatr. Psychobiol. 1989, 4:163-166.
13. Galasko D.R., Gould R.L., Abramson I.S., Salmon D.P. Measuring cognitive change in a cohort of patients with Alzheimer's disease. Stat. Med. 2000, 19(11-12):1421-1432.
14. Hanlon J.T., Horner R.D., Schmader K.E., Fillenbaum G.G., Lewis I.K., Wall W.E., et al. Benzodiazepine use and cognitive function among community-dwelling elderly. Clin. Pharmacol. Ther. 1998, 64(6):684-692.
15. Haute Autorité de Santé, 2007. Modalités d'arrĉt des benzodiazépines et médicaments apparentés chez le patient âgé. Recommandation Professionnelles, pp. 4.
16. Isaacs B., Kennie A.T. The Set test as an aid to the detection of dementia in old people. Br. J. Psychiatry 1973, 123(575):467-470.
17. Jacqmin-Gadda H., Fabrigoule C., Commenges D., Dartigues J.F. A 5-year longitudinal study of the Mini-Mental State Examination in normal aging. Am. J. Epidemiol. 1997, 145(6):498-506.
18. Lagnaoui R., Begaud B., Moore N., Chaslerie A., Fourrier A., Letenneur L., et al. Benzodiazepine use and risk of dementia: a nested case-control study. J. Clin. Epidemiol. 2002, 55(3):314-318.
19. Lagnaoui R., Tournier M., Moride Y., Wolfson C., Ducruet T., Begaud B., et al. The risk of cognitive impairment in older community-dwelling women after benzodiazepine use. Age Ageing 2009, 38(2):226-228.
20. Laird N.M., Ware J.H. Random-effects models for longitudinal data. Biometrics 1982, 38(4):963-974.
21. Lechevallier N., Fourrier A., Berr C. Benzodiazepine use in the elderly: the EVA Study. Rev. Epidemiol. Sante Publique 2003, 51(3):317-326.
22. Madhusoodanan S., Bogunovic O.J. Safety of benzodiazepines in the geriatric population. Expert Opin. Drug Saf. 2004, 3(5):485-493.
23. Morgan K., Dallosso H., Ebrahim S., Arie T., Fentem P.H. Prevalence, frequency, and duration of hypnotic drug use among the elderly living at home. Br. Med. J. (Clin. Res. Ed.) 1988, 296(6622):601-602.
24. Moride Y., Abenhaim L. Evidence of the depletion of susceptibles effect in non-experimental pharmacoepidemiologic research. J. Clin. Epidemiol. 1994, 47(7):731-737.
25. National Health Service Grampian, 2008. Guidance for prescribing and withrdawal of benzodiazepine and hypnotics in general practice, pp. 1.
26. Ohayon M.M., Lader M.H. Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom. J. Clin. Psychiatry 2002, 63(9):817-825.
27. Park H.L., O'Connell J.E., Thomson R.G. A systematic review of cognitive decline in the general elderly population. Int. J. Geriatr. Psychiatry 2003, 18(12):1121-1134.
28. Paterniti S., Dufouil C., Alperovitch A. Long-term benzodiazepine use and cognitive decline in the elderly: the Epidemiology of Vascular Aging Study. J. Clin. Psychopharmacol. 2002, 22(3):285-293.
29. Proust-Lima C., Amieva H., Dartigues J.F., Jacqmin-Gadda H. Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studies. Am. J. Epidemiol. 2007, 165(3):344-350.
30. Proust-Lima C., Amieva H., Letenneur L., Orgogozo J.M., Jacqmin-Gadda H., Dartigues J.F. Gender and education impact on brain aging: a general cognitive factor approach. Psychol. Aging 2008, 23(3):608-620.
31. Proust-Lima C., Dartigues J.F., Jacqmin-Gadda H. Misuse of the Linear Mixed Model when evaluating risk factors of cognitive decline. Am. J. Epidemiol. 2011, (Epub ahead of print).
32. Proust C., Jacqmin-Gadda H., Taylor J.M., Ganiayre J., Commenges D. A nonlinear model with latent process for cognitive evolution using multivariate longitudinal data. Biometrics 2006, 62(4):1014-1024.
33. Reitan R. Validity of the Trail Making Test as an indicator of organic brain damage. Percept. Mot. Skills 1958, 8:271-276.
34. Ritchie K., Carriere I., de Mendonca A., Portet F., Dartigues J.F., Rouaud O., et al. The neuroprotective effects of caffeine: a prospective population study (the Three City Study). Neurology 2007, 69(6):536-545.
35. Stewart S.A. The effects of benzodiazepines on cognition. J. Clin. Psychiatry 2005, 66(Suppl. 2):9-13.
36. The 3C Study Group Vascular factors and risk of dementia: design of the Three-City Study and baseline characteristics of the study population. Neuroepidemiology 2003, 22(6):316-325.
37. Verdoux H., Lagnaoui R., Begaud B. Is benzodiazepine use a risk factor for cognitive decline and dementia? A literature review of epidemiological studies. Psychol. Med. 2005, 35(3):307-315.
38. Vidal J.S., Lacombe J.M., Dartigues J.F., Pasquier F., Robert P., Tzourio C, et al. Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology 2008, 31(3):193-200.
39. WHO Collaborating Centre for Drug Statistics Methodology, 2000. Guidelines for ATC classification and DDD assignment. Oslo.
40. Wu C.S., Wang S.C., Chang I.S., Lin K.M. The association between dementia and long-term use of benzodiazepine in the elderly: nested case-control study using claims data. Am. J. Geriatr. Psychiatry 2009, 17(7):614-620.