메뉴 건너뛰기




Volumn 34, Issue 3, 2016, Pages 537-542

Concise review: Cell therapies for stroke and traumatic brain injury: Targeting microglia

Author keywords

Brain injuries; Microglia; Stem cells; Stroke

Indexed keywords

CELL THERAPY; CEREBROVASCULAR ACCIDENT; DIFFUSION TENSOR IMAGING; FRACTIONAL ANISOTROPY; GRAY MATTER; HUMAN; INFLAMMATION; MICROGLIA; NERVE DEGENERATION; POSITRON EMISSION TOMOGRAPHY; REVIEW; TRAUMATIC BRAIN INJURY; WHITE MATTER; ANIMAL; BIOLOGICAL THERAPY; BRAIN INJURIES, TRAUMATIC; GENETICS; METABOLISM; PATHOLOGY; PROCEDURES; STEM CELL TRANSPLANTATION; STROKE; TRANSPLANTATION;

EID: 84959249928     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2253     Document Type: Review
Times cited : (32)

References (38)
  • 1
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Adecola C, Anrather J,. The immunology of stroke: From mechanisms to translation. Nat Med 2011; 17: 796-808.
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Adecola, C.1    Anrather, J.2
  • 2
    • 65549130913 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    • Gelderblom M, Leypoldt F, Steinbach K, et al., Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009; 40: 1849-1857.
    • (2009) Stroke , vol.40 , pp. 1849-1857
    • Gelderblom, M.1    Leypoldt, F.2    Steinbach, K.3
  • 4
    • 33646874015 scopus 로고    scopus 로고
    • Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    • Offner H, Subramanian S, Parker SM, et al., Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol 2006; 176: 6523-6531.
    • (2006) J Immunol , vol.176 , pp. 6523-6531
    • Offner, H.1    Subramanian, S.2    Parker, S.M.3
  • 5
    • 48249100117 scopus 로고    scopus 로고
    • The spleen contributes to stroke-induced neurodegeneration
    • Ajmo CT Jr, Vernon DO, Collier L, et al., The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res 2008; 86: 2227-2234.
    • (2008) J Neurosci Res , vol.86 , pp. 2227-2234
    • Ajmo, C.T.1    Vernon, D.O.2    Collier, L.3
  • 6
    • 84920717602 scopus 로고    scopus 로고
    • Microglial and macrophage polarization - New prospects for brain repair
    • Hu X, Leak RK, Shi Y, et al., Microglial and macrophage polarization-New prospects for brain repair. Nat Rev Neurol 2015; 11: 56-64.
    • (2015) Nat Rev Neurol , vol.11 , pp. 56-64
    • Hu, X.1    Leak, R.K.2    Shi, Y.3
  • 7
    • 84891827843 scopus 로고    scopus 로고
    • Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation
    • Loane D, Kumar A, Stocia B, et al., Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation. J Neuropathol Exp Neurol 2014; 73: 14-29.
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 14-29
    • Loane, D.1    Kumar, A.2    Stocia, B.3
  • 8
    • 55149085444 scopus 로고    scopus 로고
    • Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates
    • Sidaros A, Skimminge A, Liptrot MG, et al., Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates. Neuroimage 2009; 44: 1-8.
    • (2009) Neuroimage , vol.44 , pp. 1-8
    • Sidaros, A.1    Skimminge, A.2    Liptrot, M.G.3
  • 9
    • 79951813069 scopus 로고    scopus 로고
    • Longitudinal changes in the corpus callosum following pediatric traumatic brain injury
    • Wu TC, Wilde EA, Bigler ED, et al., Longitudinal changes in the corpus callosum following pediatric traumatic brain injury. Dev Neurosci 2010; 32: 361-373.
    • (2010) Dev Neurosci , vol.32 , pp. 361-373
    • Wu, T.C.1    Wilde, E.A.2    Bigler, E.D.3
  • 10
    • 59649115401 scopus 로고    scopus 로고
    • Cerebral atrophy after traumatic white matter injury: Correlation with acute neuroimaging and outcome
    • Ding K, Marquez de la Plata C, Wang JY, et al., Cerebral atrophy after traumatic white matter injury: Correlation with acute neuroimaging and outcome. J Neurotrauma 2008; 25: 1433-1440.
    • (2008) J Neurotrauma , vol.25 , pp. 1433-1440
    • Ding, K.1    Marquez De La Plata, C.2    Wang, J.Y.3
  • 11
    • 54049158893 scopus 로고    scopus 로고
    • Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury
    • Schwarting S, Litwak S, Hao W, et al., Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury. Stroke 2008; 39: 2867-2875.
    • (2008) Stroke , vol.39 , pp. 2867-2875
    • Schwarting, S.1    Litwak, S.2    Hao, W.3
  • 12
    • 84889245910 scopus 로고    scopus 로고
    • Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke
    • Yang B, Migliati E, Parsha K, et al., Intra-arterial delivery is not superior to intravenous delivery of autologous bone marrow mononuclear cells in acute ischemic stroke. Stroke 2013; 44: 3463-3472.
    • (2013) Stroke , vol.44 , pp. 3463-3472
    • Yang, B.1    Migliati, E.2    Parsha, K.3
  • 13
    • 39749109431 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    • Lee ST, Chu K, Jung KH, et al., Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 2008; 131: 616-629.
    • (2008) Brain , vol.131 , pp. 616-629
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3
  • 14
    • 84898585310 scopus 로고    scopus 로고
    • Post-stroke inflammation and the potential efficacy of novel stem cell therapies: Focus on amnion epithelial cells
    • Article 66
    • Broughton BR, Lim R, Arumugam TV, et al., Post-stroke inflammation and the potential efficacy of novel stem cell therapies: Focus on amnion epithelial cells. Front Cell Neurosci 2013; 6. Article 66. 1-9.
    • (2013) Front Cell Neurosci , vol.6 , pp. 1-9
    • Broughton, B.R.1    Lim, R.2    Arumugam, T.V.3
  • 15
    • 84891517674 scopus 로고    scopus 로고
    • Autologous bone marrow mononuclear cell therapy attenuates activated microglia/macrophage response and improves spatial learning after traumatic brain injury
    • Bedi S, Walker PA, Shah SK, et al., Autologous bone marrow mononuclear cell therapy attenuates activated microglia/macrophage response and improves spatial learning after traumatic brain injury. J Trauma 2013; 75: 410-416.
    • (2013) J Trauma , vol.75 , pp. 410-416
    • Bedi, S.1    Walker, P.A.2    Shah, S.K.3
  • 16
    • 84888408907 scopus 로고    scopus 로고
    • Intravenous multipotent adult progenitor cell therapy improves spatial learning after traumatic brain injury
    • Bedi SS, Hetz R, Thomas C, et al., Intravenous multipotent adult progenitor cell therapy improves spatial learning after traumatic brain injury. Stem Cells Translational Med 2013; 2: 953-960.
    • (2013) Stem Cells Translational Med , vol.2 , pp. 953-960
    • Bedi, S.S.1    Hetz, R.2    Thomas, C.3
  • 17
    • 33745213287 scopus 로고    scopus 로고
    • Cord blood rescues stroke-induced changes in splenocyte phenotype and function
    • Vendrame M, Gemma C, Pennypacker KR, et al., Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol 2006; 199: 191-200.
    • (2006) Exp Neurol , vol.199 , pp. 191-200
    • Vendrame, M.1    Gemma, C.2    Pennypacker, K.R.3
  • 18
    • 54049158893 scopus 로고    scopus 로고
    • Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury
    • Schwarting S, Litwak S, Hao W, et al., Hematopoietic stem cells reduce postischemic inflammation and ameliorate ischemic brain injury. Stroke 2008; 39: 2867-2875.
    • (2008) Stroke , vol.39 , pp. 2867-2875
    • Schwarting, S.1    Litwak, S.2    Hao, W.3
  • 19
    • 77956433599 scopus 로고    scopus 로고
    • Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: Preserving the blood:brain barrier via an interaction with splenocytes
    • Walker PA, Shah SK, Jimenez F, et al., Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: Preserving the blood:brain barrier via an interaction with splenocytes. Exp Neurol 2010; 225: 341-352.
    • (2010) Exp Neurol , vol.225 , pp. 341-352
    • Walker, P.A.1    Shah, S.K.2    Jimenez, F.3
  • 20
    • 84961960575 scopus 로고    scopus 로고
    • Human multipotential bone marrow stem cells exert immunomodulatory effects, prevent splenic contraction, and enhance functional recovery in a rodent model of ischemic stroke
    • Yang B, Hamilton J, Strong R, et al., Human multipotential bone marrow stem cells exert immunomodulatory effects, prevent splenic contraction, and enhance functional recovery in a rodent model of ischemic stroke. Stroke 2011; 42: E67-E67.
    • (2011) Stroke , vol.42 , pp. E67-E67
    • Yang, B.1    Hamilton, J.2    Strong, R.3
  • 21
    • 39749109431 scopus 로고    scopus 로고
    • Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
    • Lee ST, Chu K, Jung KH, et al., Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 2008; 131: 616-629.
    • (2008) Brain , vol.131 , pp. 616-629
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3
  • 22
    • 84894084750 scopus 로고    scopus 로고
    • Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat
    • Womble TA, Green S, Shahaduzzaman M, et al., Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat. Mol Cell Neurosci 2014; 59: 76-84.
    • (2014) Mol Cell Neurosci , vol.59 , pp. 76-84
    • Womble, T.A.1    Green, S.2    Shahaduzzaman, M.3
  • 23
    • 55749098498 scopus 로고    scopus 로고
    • Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
    • Ohtaki H, Ylostalo JH, Foraker JE, et al., Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses. Proc Natl Acad Sci U S A 2008; 105: 14638-14643.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 14638-14643
    • Ohtaki, H.1    Ylostalo, J.H.2    Foraker, J.E.3
  • 24
    • 84912016664 scopus 로고    scopus 로고
    • The 18 kDa translocator protein, microglia and neuroinflammation
    • Liu GJ, Middleton RJ, Hatty CR, et al., The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathol 2014; 24: 631-653.
    • (2014) Brain Pathol , vol.24 , pp. 631-653
    • Liu, G.J.1    Middleton, R.J.2    Hatty, C.R.3
  • 25
    • 84881426292 scopus 로고    scopus 로고
    • Influence of TSPO genotype on 11C-PBR28 standardized uptake values
    • Yoder KK, Nho K, Risacher SL, et al., Influence of TSPO genotype on 11C-PBR28 standardized uptake values. J Nuclel Med 2013; 54: 1320-1322.
    • (2013) J Nuclel Med , vol.54 , pp. 1320-1322
    • Yoder, K.K.1    Nho, K.2    Risacher, S.L.3
  • 26
    • 77956263860 scopus 로고    scopus 로고
    • Two binding sites for 3HPBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation
    • Owen D, Howell, OW, Tang SP, et al., Two binding sites for 3HPBR28 in human brain: Implications for TSPO PET imaging of neuroinflammation. J Cerebral Blood Flow Met 2010; 30: 1608-1618.
    • (2010) J Cerebral Blood Flow Met , vol.30 , pp. 1608-1618
    • Owen, D.1    Howell, O.W.2    Tang, S.P.3
  • 27
    • 84871920442 scopus 로고    scopus 로고
    • A genetic polymorphism for translocator protein 19kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation
    • Kreisl WC, Jenko KH, Hinds CS, et al., A genetic polymorphism for translocator protein 19kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. J Cerebral Blood Flow Met 2013; 33: 53-58.
    • (2013) J Cerebral Blood Flow Met , vol.33 , pp. 53-58
    • Kreisl, W.C.1    Jenko, K.H.2    Hinds, C.S.3
  • 28
    • 67349283094 scopus 로고    scopus 로고
    • Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: A double tracer [11C]PK11195- and [18F]FDG-PET study
    • Schroeter M, Dennin MA, Walberer M, et al., Neuroinflammation extends brain tissue at risk to vital peri-infarct tissue: A double tracer [11C]PK11195- and [18F]FDG-PET study. J Cereb Blood Flow Metab 2009; 29: 1216-1225.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1216-1225
    • Schroeter, M.1    Dennin, M.A.2    Walberer, M.3
  • 29
    • 65349120620 scopus 로고    scopus 로고
    • Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain
    • Cosensa-Nashat M, Zhao ML, Suh HS, et al., Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol Appl Neurobiol 2009; 35: 306-328.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 306-328
    • Cosensa-Nashat, M.1    Zhao, M.L.2    Suh, H.S.3
  • 30
    • 80052585240 scopus 로고    scopus 로고
    • Inflammation after trauma: Microglial activation and traumatic brain injury
    • Ramlackhansingh AF, Brooks DJ, Greewood RJ, et al., Inflammation after trauma: Microglial activation and traumatic brain injury. Ann Neurol 2011; 70: 374-383.
    • (2011) Ann Neurol , vol.70 , pp. 374-383
    • Ramlackhansingh, A.F.1    Brooks, D.J.2    Greewood, R.J.3
  • 31
    • 84891827843 scopus 로고    scopus 로고
    • Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation
    • Loane DJ, Kumar A, Stoica BA, et al., Progressive neurodegeneration after experimental brain trauma: Association with chronic microglial activation. J Neuropathol Exp Neurol 2014; 73: 14-29.
    • (2014) J Neuropathol Exp Neurol , vol.73 , pp. 14-29
    • Loane, D.J.1    Kumar, A.2    Stoica, B.A.3
  • 32
    • 84907678837 scopus 로고    scopus 로고
    • In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats
    • Walberer M, Jantzen SU, Backes H, et al., In-vivo detection of inflammation and neurodegeneration in the chronic phase after permanent embolic stroke in rats. Brain Res 2014; 1581: 80-88.
    • (2014) Brain Res , vol.1581 , pp. 80-88
    • Walberer, M.1    Jantzen, S.U.2    Backes, H.3
  • 33
    • 67349093015 scopus 로고    scopus 로고
    • A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke
    • Yu C, Zhu C, Zhang Y, et al., A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke. Neuroimage 2009; 15; 47: 451-458.
    • (2009) Neuroimage , vol.15 , Issue.47 , pp. 451-458
    • Yu, C.1    Zhu, C.2    Zhang, Y.3
  • 34
    • 77957072864 scopus 로고    scopus 로고
    • The temporal dynamics of poststroke neuroinflammation: A longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke
    • Thiel A, Radlinska BA, Paquette C, et al., The temporal dynamics of poststroke neuroinflammation: A longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. J Nucl Med 2010; 51: 1404-1412.
    • (2010) J Nucl Med , vol.51 , pp. 1404-1412
    • Thiel, A.1    Radlinska, B.A.2    Paquette, C.3
  • 35
    • 20144388272 scopus 로고    scopus 로고
    • Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury
    • Wilde EA, Hunter JV, Newsome MR, et al., Frontal and temporal morphometric findings on MRI in children after moderate to severe traumatic brain injury. J Neurotrauma 2005; 22: 333-344.
    • (2005) J Neurotrauma , vol.22 , pp. 333-344
    • Wilde, E.A.1    Hunter, J.V.2    Newsome, M.R.3
  • 36
    • 79951774905 scopus 로고    scopus 로고
    • Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children
    • Cox CS, Baumgartner JE, Harting MT, et al., Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery 2011; 68: 588-600.
    • (2011) Neurosurgery , vol.68 , pp. 588-600
    • Cox, C.S.1    Baumgartner, J.E.2    Harting, M.T.3
  • 37
    • 55349092961 scopus 로고    scopus 로고
    • Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: Relation to neurobehavioral outcomes
    • Ewing-Cobbs L, Prasad MR, Swank P, et al., Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: Relation to neurobehavioral outcomes. Neuroimage 2008; 42: 1305-1315.
    • (2008) Neuroimage , vol.42 , pp. 1305-1315
    • Ewing-Cobbs, L.1    Prasad, M.R.2    Swank, P.3
  • 38
    • 47949120071 scopus 로고    scopus 로고
    • Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging
    • Bendlin BB, Ries ML, Lazar M, et al., Longitudinal changes in patients with traumatic brain injury assessed with diffusion-tensor and volumetric imaging. Neuroimage 2008; 42: 503-514.
    • (2008) Neuroimage , vol.42 , pp. 503-514
    • Bendlin, B.B.1    Ries, M.L.2    Lazar, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.